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Aims: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. Materials and methods: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibi
Atomic layer deposited (ALD) TiO2 thin films have a wide range of applications in photonics which are, however, limited by the chemical instability of the amorphous as-deposited TiO2. Post-deposition annealing is required for improving the performance by inducing phase transitions and oxide defects. ALD precursor traces remaining in the TiO2 film affect the thermally-induced processes but the unde
BACKGROUND AND OBJECTIVES: Stroke genetic research has made substantial progress in the past decade. Its recovery application, however, remains behind, in part due to its reliance on the modified Rankin Scale (mRS) score as a measure of poststroke outcome. The mRS does not map well to biological processes because numerous psychosocial factors drive much of what the mRS captures. Second, the mRS co
We investigate the impact of a galaxy’s merger history on its system of satellites using the new VINTERGATAN-GM suite of zoom-in hydrodynamical simulations of Milky Way-mass systems. The suite simulates five realizations of the same halo with targeted ‘genetic modifications’ of a z ≈ 2 merger, but resulting in the same halo mass at z = 0. We find that differences in the satellite stellar mass func
The electric and magnetic polarizabilities of the proton are now well known, owing to Compton scattering measurements on hydrogen targets; however, the neutron polarizabilities are still relatively uncertain, compared to the proton values. To address this problem, a multiinstitutional collaboration has conducted a program of elastic Compton scattering experiments on deuterium at the MAX IV Laborat
Parasites of the genera Plasmodium and Haemoproteus (Apicomplexa: Haemosporida) are a diverse group of pathogens that infect birds nearly worldwide. Despite their ubiquity, the ecological and evolutionary factors that shape the diversity and distribution of these protozoan parasites among avian communities and geographic regions are poorly understood. Based on a survey throughout the Neotropics of
Climate change and drought phenomena impacts have become a growing concern for water resources engineers and policy makers, mainly in arid and semi-arid areas. This study aims to contribute to the development of a decision support tool to prepare water resources managers and planners for climate change adaptation. The Hydrologiska Byråns Vattenbalansavdelning (The Water Balance Department of the H
The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 outbreak on pediatric transplant activity and healthcare practices in both solid o
The adoption of artificial intelligence (AI) technologies has become increasingly relevant in everyday life, yet empirical evidence from non-WEIRD countries remains limited. This thesis examined psychological factors associated with the general intention to use AI in Guatemala using the Technology Acceptance Model 3 (TAM3) as a guiding framework. Data were collected through a cross-sectional surve
Amino acids that are in close contact in a protein structure tend to co-evolve, which gives rise to sequence correlations. Direct coupling analysis (DCA) is a method for predicting such contacts directly from sequence correlations, without assuming any prior knowledge of structures. To this end, sequence correlations are modeled using an Ising-like ansatz, whose couplings are determined through an
Ett väl fungerande skattesystem utgör basen för finansieringen av välfärdssystemet. Skatteflykt ger upphov till skattebaserosion, ett fenomen som ger upphov till stora kostnader, såväl för Sverige som för andra stater och försvårar finansieringen av välfärdssystemet. Generalklausuler utgör ett verktyg mot skatteflykt. I Sverige finns sedan många år tillbaka en generalklausul mot skatteflykt i skatThe basis for the funding of welfare systems is a well-functioning tax system. Tax base erosion, founded in tax avoidance, imposes significant costs for both Sweden and other countries and it risks obstructing the funding of the welfare system. General Anti-Avoidance Rules (GAARs) is an instrument for countering tax avoidance. For many years, Sweden has had a GAAR in the Swedish Anti-Avoidance Act
The creative economy (CE) has recently been at the forefront of Indonesia’s development agenda. By harnessing human creativity and cultural resources, there is considerable potential for CE and the creative and cultural industries to contribute to economic growth and generate employment opportunities for the country’s expanding working-age population. However, the virtues of CE have largely been e
Konkurrensklausuler i anställningsavtal avser att begränsa arbetstagares rätt att fritt konkurrera efter avslutad anställning. Uppsatsen ämnar att bedöma om 2015 års överenskommelse om konkurrensklausuler är att betrakta som god sed på arbetsmarknaden. Denna fråga måste först besvaras innan uppsatsens huvudfråga kan besvaras, nämligen om perdurerande viten är tillåtna i konkurrensklausuler och om The purpose of a competition clause in a employment contract is to restrain the employees possibilities to compete with the former employer after he or she quits the employment. This study aims to assess if the 2015 collective agreement on competition clauses in employment contracts is to be regarded as good practice in the Swedish labor market i.e become binding on all employers and employees whe
Over the recent years the interest in cryptocurrencies and Bitcoin has increased significantly. The price of Bitcoin has gone up substantially since the end of 2020 and more individual and institutional investors are incorporating Bitcoin to their portfolio. This thesis explores the features of Bitcoin as another financial asset, specifically compared to Gold as Bitcoin has been referred to as the
Microfluidic devices have so far not seen widespread use, even though they could potentially be cheaper, better and faster than traditional methods. A possible reason for this is the lack of a middle step between one-of-a-kind experimental devices and cheap mass produced devices. With ongoing improvements in resolution it is starting to look possible that 3D-printing will fill this role. This the
Cyclometallation is an important reaction and is essential in organometallic chemistry for the synthesis of stable metal-ligand frameworks and in the development of functional catalytic compounds. Although extensively studied, challenges remain in achieving selective C-H bond activation without the formation of unwanted side products. In this study, a PCP pincer ligand and subsequent cyclopalladat
Sammanfattning Syftet med denna uppsats är att undersöka hur EU-rätten påverkar den svenska arbetsrättsliga modellen, särskilt arbetsgivarens generella informationsplikt och om Sverige har levt upp till de krav som EU-rätten ställer vid införlivandet av direktiv 2002/14/EG om införlivande av allmän ram för information till och samråd med i Europeiska gemenskapen, gällande nationella förhållanden. The purpose of this paper is to examine how EU law influences the Swedish labour law model, particularly the general obligation of employers to provide information and concerning, whether Sweden has lived up to the requirements imposed under EU law regarding the implementation of the directive 2002/14/EC establishing a general framework for informing and consulting employees in the European Commun
