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The topic of this thesis is bioprocess control, more specifically control of industrial-scale microbial fed-batch bioprocesses. Its focus is therefore on methods which are easy to implement in an industrial setting, which gives certain limitations on sensors, actuators and control systems. The main part of the work in the thesis concerns control of the microbial substrate uptake rate by manipulat
The prime objective of this study is to investigate if radioluminescence (RL) from carbon-doped aluminum oxide (Al2O3:C) crystals potentially can be used for absorbed dose-rate measurements during proton radiotherapy. The RL from two separate (2 mg) Al2O3:C crystals attached to optical-fiber cables were recorded during irradiations in water in a 175 MeV clinical proton beam. The RL response for lo
BACKGROUND: Roux-en-Y gastric bypass is a bariatric procedure of choice. There is evidence supporting a small isolated pouch and a wide anastomosis. Gastric vascular anatomy renders the ventral aspect less suited for anastomotic construction. The lesser curvature has abundant blood supply that should preferably not be interfered with. Terminal anastomosis is a logical choice. METHODS: We devised a
Background: Home mechanical ventilation (HMV) and long-term oxygen therapy (LTOT) are the two treatment alternatives when treating respiratory insufficiency in patients with kyphoscoliosis. We aimed to study the effect on survival with regard to HMV or LTOT alone in patients with respiratory insufficiency due to kyphoscoliosis. Methods: Swedish patients with nonparalytic kyphoscoliosis (ie, scolio
The cAMP-elevating pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates insulin release in pancreatic B-cells. Here, we have investigated its potentiating action in rat insulinoma INS-1 cells. In intact cells, PACAP-27 (100 nM) stimulated glucose-induced insulin secretion by >60%. Using the patch-clamp technique with single-cell exocytosis monitored as increases in cell capacitanc
The aim of this study is to examine a possible fusion of the different legal regimes applicable to international and non-international armed conflicts. The thesis points at different means of rendering the provisions of the Geneva Conventions applicable to conflicts which appear to be non-international. The Conventions are interpreted according to the provisions on interpretation of treaties in th
During 2007, a legal reform in Sweden took place, this change led to complications in interpreting the needs of individuals and the application of the laws by the governing social authorities. The aim of the thesis is to explore the underlying norms that influence social workers interpretation of young offenders needs, aged 15 to 17 years, and if the interpretations are consistent. The aim was ach
High-spin states have been studied in 72,73Kr using 40Ca+40Ca and 36Ar+40Ca reactions at 160, 164 and 145 MeV respectively. The properties and configurations of the bands observed are interpreted with the aid of unpaired cranked Nilsson-Strutinsky/ cranked relativistic mean-field calculations and paired total routhian surface and cranked relativistic Hartree-Bogoliubov calculations. In 73Kr the th
Background: Repeat prescribing used in long-term pharmacotherapy is often associated with inadequate patient medication, including non-adherence. In this paper we explore patients' drug refill adherence with repeat prescriptions and relate refill data to patient age and gender, type of prescriber, type of prescribed drug, and reimbursement level. Methods: During one week of 2002, copies of 3636 re
The synthesis and crystal structure of rhodamine 590 acid phthalate (RhAP) have been reported. This novel solid-state rhodamine derivative not only has a longer fluorescence lifetime compared to rhodamine solid-state matrixes where emission is quenched but also possesses strong nonlinear optical characteristics. The static and dynamic first- and second-order hyperpolarizabilities were calculated u
The foraging activity of diurnal bees often relies on flower availability, light intensity and temperature. We do not know how nocturnal bees, which fly at night and twilight, cope with these factors, especially as light levels vary considerably from night to day and from night to night due to moon phase and cloud cover. Given that bee apposition compound eyes function at their limits in dim light
The objective of this article is to review guidelines that address counselling in the context of genetic testing in order to summarise what aspects of counselling they consider most important, and to examine how they construct the ideal of genetic counselling. Guidelines were collected by examining the websites of different international professional, political, ethical and patient organisations,
Soil fungal biomass, microfungal species composition, and soil respiration rate of conifer mor soil were studied along a steep copper and zinc gradient (up to 20,000 ,ug of Cu and 20,000 ,ug of Zn g-1 dry soil) around a brass mill near the town of Gusum in South Sweden. Fungal biomass and soil respiration rate decreased by about 75% along the metal gradient. Above 1,000 ,ug of Cu g- 1, the decreas
The Internet offers a plethora of venues for autobiographical self-representation: webcams, personal websites, blogs. There is much research on self-representation online, whereas very little research has focused on the consumption of online self-representation. This article focuses on the act of reading diary blogs. Who are the actual readers of a specific blog and what values do they place on th
When a limiting resource (e.g. food) varies drastically between years, and population density is measured in the conventional way as individuals per area, demographic processes such as productivity and survival may erroneously be considered density-independent. We tested the hypothesis that if the variation in a limiting resource is not taken into account in the density measure, this may lead to e
Arbuscular mycorrhizal (AM) cucumber seedlings and uncolonized controls were grown in growth chambers which allowed separation of compartments with roots from compartments with the extraradical mycelium alone. Two fungi, Glomus invermaium Hall and G. caledonium (Nicol. and Gerd.) Trappe and Gerdemann, were used. Bacterial numbers (direct and viable count) and activities (thymidine incorporation) w
The A (1)Sigma(+) potential energy curve of AgH is studied by means of the second-order multistate multireference perturbation theory including the spin-orbit and relativistic effects. The anomalous behavior of the vibrational energy levels observed in experiment is reproduced well by theory. An analysis of the A (1)Sigma(+) wave function shows that at the internuclear distance of 4-6 Angstrom, a
