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The increasing number of bacterial genomes in combination with reproducible quantitative proteome measurements provides new opportunities to explore how genetic differences modulate proteome composition and virulence. It is challenging to combine genome and proteome data as the underlying genome influences the proteome. We present a strategy to facilitate the integration of genome data from severa
Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change susceptibility and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agents and body components or processes. The need for improved reporting of scientific research led to infl
Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agent.; and the body components or processes. The need for improved reporting of scientific research led t
The CD24 glycoprotein is a mediator of neuronal proliferation, differentiation and immune suppression in the normal CNS, and a proposed cancer biomarker in multiple peripheral tumor types. We performed a comparative analysis of CD24 gene expression in a large cohort of pediatric and adult brain tumors (n = 813), and further characterized protein expression in tissue sections (n = 39), primary brai
Gonyostmum semen is a freshwater raphidophyte that has increased in occurrence and abundance in several countries in northern Europe since the 1980s. More recently, the species has expanded rapidly also in north-eastern Europe, and it is frequently referred to as invasive. To better understand the species history, we have explored the phylogeography of G. semen using strains from northern Europe,
Rose hips and sea buckthorn berries contain high amounts of beneficial bioactive compounds. In this study the content and stability of natural vitamins and antioxidants were investigated in two fruit beverages made from rose hip powder, sea buckthorn berry puree and white grape juice concentrate, and wheat germ oil in one of the beverages. Beverages were formulated, pasteurised and filled aseptica
Establishing a tractable yet complete reaction coordinate for the spin-state interconversion in d(4)-d(7) transition metal complexes is an integral aspect of controlling the dynamics that govern their functionality. For spin crossover phenomena, the limitations of a single-mode approximation that solely accounts for an isotropic increase in the metal-ligand bond length have long been recognized fo
Organic semiconductors usually demonstrate crystal structure dependent electronic properties, and through precise control of film structure, the performance of novel organic electronic devices can be greatly improved. Understanding the crystal structure dependent charge-transfer mechanism thus becomes critical. In this work, we have prepared amorphous titanyl phthalocyanine films by vacuum molecul
Popular Abstract in Swedish Många fåglar flyttar regelbundet långa sträckor mellan sina häckningsplatser och vinterkvarter. På rastningsplatser längs flyttningsvägen stannar fåglarna upp och äter, för att lagra upp de energi-lager de behöver som bränsle när de flyger. Vissa flyttfåglar lägger på sig så mycket bränsle (energi), mestadels som fett, att de dubblar sin kroppsvikt. Det lagrade bränsletBirds on migration alternate between consuming fuel stores during flights and accumulating fuel stores during stopovers. This thesis highlights some of the ways in which migrating birds have adapted to the different demands of fuelling and flight. Most of the time on migration is spent at stopover sites accumulating fuel stores. To minimise the total time spent on migration, birds should fuel up a
Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess
Phenyl β-d-galactopyranoside was found to be an efficient acceptor of l-[14C]fucose when guanosine diphosphate l-[14C]fucose was used as the donor substrate and human serum, submaxillary glands or stomach mucosa were the sources of l-fucosyltransferase. The enzyme utilising phenyl β-D-galactoside was present in the serum of donors of all ABO blood-groups examined, except those of the rare Oh (Bomb
Any new technology and any form of contact between cultures will necessarily lead to change. ICTs are in this sense far from unique. However, ICTs have rapidly come to occupy a prominent position our societies, and are shaping the lives of young people in ways that we could not have imagined only a decade ago. These technologies allow almost immediate access to a wealth of knowledge and knowhow, a
Floodplain surface topography is an important component of floodplain ecosystems. It is the primary physical template upon which ecosystem processes are acted out, and complexity in this template can contribute to the high biodiversity and productivity of floodplain ecosystems. There has been a limited appreciation of floodplain surface complexity because of the traditional focus on temporal varia
Purpose - The purpose of this study is to provide a new perspective for effective management of the merger and acquisition (M&A) process by making use of a case study of a merger in the Japanese pharmaceutical industry. As corporate governance and culture are notably employee-oriented in Japanese firms, the paper seeks to explore whether M&As in the industry may follow different paths from
This study is about the extent of how church law (of 1571, 1686 and 2000) in Sweden has affected and still affects the church's welfare administrations such as schools, hospitals and care institutions. Recent studies seem to indicate that the Church of Sweden is aiming to start expanding its organisation to include more social welfare activities to meet increasing demands from the general publ
Då smarttelefoner på kort tid har blivit oumbärliga verktyg i många människors vardag har frågor kring hur användare psykiskt påverkas av dem väckts. Studier har funnit samband mellan smarttelefonanvändning och psykisk ohälsa, men i många fall baserat på bristfälliga data. Den här studien syftade att vidare undersöka sambandet mellan smarttelefonanvändning och upplevd psykisk ohälsa samt att underSmartphones have rapidly become indispensable tools in everyday life, leading to questions about their psychological impact on users. Studies have found associations between smartphone use and mental health problems, but in many cases based on insufficient data. This study’s purpose was to further explore the relationship between smartphone use and experienced mental health problems, and to determ
Children’s participation could seem to be an obvious ingredient in social services child protection investigations. Children’s rights to make their voice and opinion heard and to affect the decisions that involve them is stated in law, conventions and other regulations. Despite this, a lot of previous studies show that children’s rights often are forgotten or non-prioritized in social services. Th
In recent decades, digitalisation has been a catalyst for economic growth, along which a vital need emerged for contemporary organisations to rapidly anticipate and react to changes. Organisational change is thus a recognised and widely researched topic within the literature. As we study a software implementation, executed as planned change project, we take on a process perspective on change, part
AIM: The aim of this study was to investigate early changes in uptake of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) in vivo and in vitro in a squamous-cell carcinoma (SCC) cell line originating from a human head and neck SCC during cytotoxic therapy with respect to metabolism in tumor cells and in surrounding stromal tissue. MATERIALS AND METHODS: In 60 nude mice with xenografted SCC, 50 animals were
