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Owing to the heterogeneity in the clinical phenotype of haemophilia A and B, it is now recognized that disease severity (based on factor VIII/IX activity) may no longer be the most appropriate guide for treatment and that a 'one-size-fits-all' approach is unlikely to achieve optimal therapy. Based on the present literature and consensus views of a group of experts in the field, this article highli
This thesis is divided into two separate parts. The first part is about Dynamic Programming for non-trivial optimal control problems. The second part introduces some useful tools for analysis of stability and performance of systems with time-varying delays. The two papers presented in the first part attacks optimal control problems with finite but rapidly increasing search space. In the first pap
Culture of dispersed smooth muscle cells is known to cause rapid modulation from the contractile to the synthetic cellular phenotype. However, organ culture of smooth muscle tissue, with maintained extracellular matrix and cell-cell contacts, may facilitate maintenance of the contractile phenotype. To test the influence of culture conditions, structural, functional, and biochemical properties of r
Popular Abstract in Swedish Provtagning av vätskan mellan utbyteskärl och celler i läderhuden (dermis), den så kallade interstitialvätskan (IF), kan vara ett intressant alternativ eller komplement till blodprovstagning när det gäller bestämning av såväl kroppsegna substanser som läkemedel. Inom klinisk medicin finns ett behov för att undvika smärtsamma stick i samband med provtagning, till exempelDermal interstitial fluid (IF) was extracted serially and painlessly by brief suction for as long as 6 days. The erosion was otherwise kept occluded, Sample volumes exceded those required for measuring a wide range of biological substances. Epidermal regeneration was rapid. Glucose concentrations in IF and plasma, measured in diabetic and non-diabetic subjects for as long as 6 days were closely c
The Baltic Sea Region is rapidly becoming one of the world’s more competitive regions. The region is capitalising on its strengths and making the most of its diversity to stimulate innovation, build a strong pool of skilled labour and foster entrepreneurship. A deep spirit of co-operation and integration has led the Baltic Sea countries to set up ambitious governance frameworks to pursue economic
What are the social positions of adults who were in long-term foster care as children, compared with the general population and with adults who grew up at home in families similar to foster children's birth families? How common is it to have been in foster care? Four approaches are used in this study: - A systematic review of around 50 studies on adult foster children. Conclusions are more pessim
Four years have passed since January 1996 when retail competition was introduced in the Swedish electricity market. These years have been characterized by a rapid restructuring of the electricity supply industry through mergers and acquisitions, lower electricity prices, and a search for new marketing strategies in the competitive market. General trends and the results of two market surveys, under
The Umkondo Large Igneous Province (LIP) is represented by widespread (similar to 2.0 x 10(6) km(2)) mafic intrusions that were rapidly emplaced (1112-1108 Ma) into the Kalahari craton of southern Africa and the formerly adjacent Grunehogna Province of Antarctica during Rodinia assembly. Very few Umkondo-aged dykes have been identified before, resulting in a poor understanding of this LIP's plumbi
The c-myc proto-oncogene was analyzed in 311 cases of primary breast cancer, in 8% of which it was found to be amplified, usually at moderately increased copy number (2-5 copies). The adjacent pvt gene was co-amplified with c-myc in all tumors analyzed. C-myc amplification was significantly correlated to a high S-phase fraction and to amplification of the c-erbB-2 proto-oncogene. Weak relationship
Sediment successions from the Kanin Peninsula and Chyoshskaya Bay in northwestern Russia contain information on the marginal behaviour of all major ice sheets centred in Scandinavia, the Barents Sea and the Kara Sea during the Eemian - Weichselian. Extensive luminescence dating of regional lithostratigraphical units, supported by biostratigraphical evidence, identifies four major ice advances at 1
Soil communities in landscapes that are rapidly changing due to a range of anthropogenic processes can be regarded as highly transient systems where interactions between competing species or trophic levels may be seriously disrupted. In disturbed communities dispersal in space and time has a role in ensuring continuity of community function. Stable communities, in undisturbed systems, are more dep
An all-solid-state fast-tuning lidar transmitter for range- and temporally resolved atmospheric gas concentration measurements has been developed and thoroughly tested. The instrument is based on a commercial optical parametric oscillator (OPO) laser system, which has been redesigned with piezoelectric transducers mounted on the wavelength-tuning mirror and on the crystal angle tuning element in t
Forest certification can be conceived as one of many rapidly growing non-state market driven (NSMD) modes of governance. The environmental effectiveness of forest certification is oftentimes evaluated by indicators such as stringency of standards, degree of participation by key stakeholders, certified area, etc. In political science, forest certification as an NSMD governance arrangement is usuall
We present palaeomagnetic and cosmogenic radionuclide records of the Laschamp geomagnetic excursion in Lake Pupuke, a maar lake in Auckland, New Zealand. Laschamp was identified by a combination of relative palaeointensity, (10)Be and (14)C data from the lake sediments and represents the first such record from the Southern Hemisphere. Despite the high organic carbon content, which causes relativel
The ETV6/RUNX1 fusion gene, present in 25% of B-lineage childhood acute lymphoblastic leukemia (ALL), is thought to represent an initiating event, which requires additional genetic changes for leukemia development. To identify additional genetic alterations, 24 ETV6/RUNX1-positive ALLs were analyzed using 500K single nucleotide polymorphism arrays. The results were combined with previously publish
A measurement of the multi-strange Xi(-) and Omega(-) baryons and their antiparticles by the ALICE experiment at the CERN Large Hadron Collider (LHC) is presented for inelastic proton-proton collisions at a centre-of-mass energy of 7 TeV. The transverse momentum (p(T)) distributions were studied at mid-rapidity (vertical bar y vertical bar < 0.5) in the range of 0.6 < p(T) < 8.5 GeV/c Xi(-) for an
We discuss new diffractive mechanism of central exclusive production of W+W- pairs in proton-proton collisions at the LHC. We include diagrams with intermediate virtual Higgs boson as well as quark box diagrams. Several observables related to this process are calculated. Predictions for the total cross section and differential distributions in W-boson rapidity and transverse momentum as well as WW
A method is described in which light gradients and spectral regime can be measured within plant tissue using fiber optics. A fiber optic probe was made by modifying a single optical fiber (200 μm diameter) so that it had a light harvesting end that was a truncated tip 20–70 μm in diameter. The probe was a directional sensor with a half-band acceptance angle of 17–20°. Light measurements were made
