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Background: Cerebral ischemia results in enhanced expression of contractile cerebrovascular receptors, such as endothelin type B (ETB), 5-hydroxytryptamine type 1B (5-HT1B), angiotensin II type 1 (AT(1)) and thromboxane (TP) receptors in the cerebral arteries within the ischemic area. The receptor upregulation occurs via activation of the mitogen-activated protein kinases (MAPK) pathway. Previous
Background Empirical data about end-of-life decision-making practices are scarce. We aimed to investigate frequency and characteristics of end-of-life decision-making practices in six European countries: Belgium, Denmark, Italy, the Netherlands, Sweden, and Switzerland. Methods In all participating countries, deaths reported to death registries were stratified for cause (apart from in Switzerland)
About 10% of the patients with neurofibromatosis type 1 (NF1) develop malignant peripheral nerve sheath tumors (MPNSTs), accounting for half of all MPNST cases. Several nonrandom chromosomal aberrations have been found, but the target genes remain mostly unrecognized. Mutations in the NF1 and TP53 genes have been found in some MPNSTs, and recent data from mouse models support a synergistic effect
Purpose: To report a family affected by familial exudative vitreoretinopathy (FEVR) in which more severe disease phenotypes segregated with digenic rather than monogenic variants in FEVR-related genes. Methods: Phenotype was documented with high-resolution imaging of retinal structure and wide-field fundus photography. Next-generation sequencing (NGS) of known genes involved in FEVR was performed.
Lake restoration practices based on reducing fish predation and promoting the dominance of large-bodied Daphnia grazers (i.e., biomanipulation) have been the focus of much debate due to inconsistent success in suppressing harmful cyanobacterial blooms. While most studies have explored effects of large-bodied Daphnia on cyanobacterial growth at the community level and/or on few dominant species, pr
Det är vedertaget i svensk rätt att avtal om framtida överlåtelse av fast egen- dom, såsom optionsavtal, är ogiltiga. En option är en rätt, men inte skyldighet, att i framtiden köpa eller sälja viss egendom. Även om det inte framgår explicit i lagtext eller förarbeten föreligger alltså i praktiken ett förbud mot option till fast egendom. Uppsatsens syfte är att granska huruvida det föreligger skälAgreements concerning future real estate transactions, such as option agree- ments, are invalid in the Swedish legal system. An option constitutes a right, but not an obligation, to buy or sell certain property in the future. There is a prohibition against option agreements to real estate, although it does not appear explicitly in the text of a law or the legislative history. The purpose of this t
The purpose of this study was to investigate men's experiences of being subjected to domestic violence by their female partners, identify the consequences of this violence, and analyse barriers to seeking help or leaving the relationship. The goal is to understand the nature of the violence and its impact on the men involved. Two theories have been used to analyse the results: Goffman’s theory
I uppsatsen undersöks lagregleringen om överskottsinformation vid användning av hemliga tvångsmedel i rättegångsbalken. Överskottsinformation är information som har med annat att göra än den utredning den hemliga tvångsåtgärden användes för. Lagändringen år 2023 innebär att informationen uttryckligen får användas för ”andra ändamål” än den ursprungliga utredningen vilket kan avse brott eller helt The essay examines the legal regulation on excess information when using secret measures of surveillance in the Code of Judicial Procedure . Excess information is information that pertains to matters other than the investigation for which the secret measure of surveillance was used. The 2023 legislative amendment explicitly allows the information to be used for “other purposes” than the original i
Barnkonventionens artikel 3 och 12 ger uttryck för två centrala principer inom barnrätten, vilka även är fastställda i andra svenska lagar som föräldrabalken och lagen med särskilda bestämmelser om vård av unga. Principen om barnets bästa innebär att vid samtliga åtgärder som rör barn ska barnets bästa vara avgörande. Vid denna bedömning ska varje barn få chansen att uttrycka sina åsikter, vilka s
Buildings that are built and the asphalt that is used for the paving needs to be tested to see if they fulfill certain requirements and standards. These types of tests are performed at Peab’s technology centers/laboratories and it is in one of their labs in Helsingborg that the degree project has been executed. As soon as the laboratory gets a concrete sample, they are supposed to register it in t
Microsoft Word - Academic Activities of G K Karanth as ICCR Chair Professor.docx Academic Activities of G K Karanth, ICCR Chair Professor, during September 2011 to June 2012 September 14, 2011 Arrival in Lund, and the following week following, settling down in the Department and fulfilling formalities with Bank, University, SASNET, etc.
https://www.sasnet.lu.se/sites/sasnet.lu.se/files/academic_activities_of_g_k_karanth_as_iccr_chair_professor.pdf - 2026-07-20
The pharmaceutical industry uses animal models in a variety of settings including safety, pharmacodynamic modelling and efficacy. Conventionally, a frequentist design of standard animal experiments of human asthma replication includes repeatedly running treatment groups with the exact layout, focusing on effect size rather than capturing historical data of animal responses on compounds of interest
Bakgrund: Kulturhistoriska byggnader har ett särskilt historiskt, estetiskt eller socialt värde och skyddas av regler som begränsar förändringar. Med rätt byggnadsvård och tekiska lösningar kan bevarande kombineras med energieffektiviseringar. Även om bevarande ofta innebär högre initiala kostnader, kan det ge långsiktiga värden både kulturellt och ekonomiskt. Syfte: Syftet är ett undersöka hur kThroughout history, construction practices have reflected the materials, knowledge, and economic resources available at the time. These historical characteristics are now seen as cultural assets worth preserving. However, older buildings often fail to meet modern standards, necessitating significant interventions to comply with today’s regulations. This thesis explores the challenges and opportun
Several studies have reported a declining reading rate in school-aged children. Thus, this thesis therefore aimed to evaluate how students in their last semester of high school (gymnasiet) would have their attentive behaviour affected when reading challenging texts, and with the allowance or the prohibition of the use of electronic devices in the classroom. The purpose of the study was to foster a
Bipolar disorder has long been associated with increased risks for suicidality; though factors associated with dying by suicide remain obscure. Here, we retrospectively examine the associations between the different phases of bipolar illness and other common comorbidities with death by suicide in the 120 days following each discharge for Swedes first admitted as inpatients for bipolar disorder dur
It is currently unclear how often genes that are mutated to cause rare, early-onset monogenic forms of disease also harbor common variants that contribute to the more typical polygenic form of each disease. The gene for MODY3 diabetes, HNF1 alpha, lies in a region that has shown linkage to late-onset type 2 diabetes (12q24, NIDDM2), and previous association studies have suggested a weak trend towa
The evolution of globular star clusters tells the history of the formation of galaxies, how stellar streams might have formed and how the future of the Universe might look like. Although the general theoretical background of the evolution is well understood, it is difficult to conduct accurate and realistic computer simulations of objects containing thousands of interacting bodies. This project in
Migration and Asylum-seeking has been a phenomenon for a long time in the world history. Due to many conflicts in the world events of 2015, it has been a risen migration to Sweden. The Swedish government meant that the situation with the high amount of arriving-migrants was unbearable and a direct threat to the safety in Swedish society. This because other EU country governments did not follow the
Anestesiläkare rapporterades i en svensk studie ha en högre mortalitet än genomsnittet av läkare. Detta fynd har dock ej kunnat reproduceras i motsvarande studier i de övriga nordiska länderna. Likväl har det spekulerats i om den angivna överrisken bland svenska anestesiläkare kan relateras till gruppens jourarbete med höga krav, nattarbete och stress. Kunskapen om hälsoeffekter av läkares jourarb
A set of 15 analog chest images was digitized with a high performance scanner and manipulated in terms of noise and resolution to yield three sets of images; the original plus two with different noise and resolution properties. These sets were evaluated with Visual Grading Analysis (VGA) where the observer rates the visibility of certain normal anatomical structures (as described by the European Q
