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OBJECTIVES: To explore the associations between frailty and reproductive axis hormones (as an important regulatory system) in middle aged and older men. DESIGN: Cross-sectional. SETTING: The European Male Aging Study. PARTICIPANTS: Three thousand two hundred nineteen community-dwelling European men aged 40 to 79. MEASUREMENTS: Interviewer-assisted questionnaires to assess physical activity, health
A significant proportion of the diversity of species seen today are insects and their host plants, and the evolutionary mechanisms behind their radiation have long captured the interest of biologists. The peacock flies of the large genus Tephritis (Tephritidae) use different host plants in the family Asteraceae for their reproduction. There is variation both in use of host plant species and in the
III-V semiconductors are a profound part of the optoelectronics industry and new developments in alloy compositions and architectures are constantly emerging. Lowdimensional semiconductors, such as nanowires (NWs) have shown to have improved characteristics in certain areas such as enhanced light absorption and can furthermore be integrated on Silicon (Si) plattforms and are thus predicted to be a
Välgrundade förutsägelser av olika livsmedels kvalitet och säkerhet är mycket viktiga för att förebygga matsvinn. Ofta görs dessa förutsägelser med hjälp av lagringsstudier där produkten lagras i förhållanden som simulerar produktens väg från producent till dagligvaruhandel. Dessa studier kräver mycket resurser och tid, vilket belyser behovet av accelererade hållbarhetsstudier – som är baserade påAccurate predictions about the quality and safety of food are critical to prevent food waste. Often, food is stored in conditions simulating a product’s way from production to retail, which allows producers to assess quality and safety during the product’s shelf life. These storage trials are costly and time-consuming, meaning that there is incentive to reduce the testing time. Accelerated shelf-l
Warnings of pathogens manufactured to target a specific ethnic group, so-called genetic bioweapons, have recently received considerable media attention. Genetic bioweapons figure prominently in reports on potential future risks emerging from combining genetic research, artificial intelligence and synthetic biology. They are also part of political narratives signaling imminent danger because of ong
Denna uppsats är en kvalitativ aktionsstudie som genom intervjuer undersöker hur lärare och elever på ett estetiskt program resonerar kring och definierar begreppet “personligt uttryck” samt vad de tänker ska utföras för att uppfylla kunskapskravet innehållande begreppet. Detta i syfte att öka kunskapen i huruvida samsyn råder eller inte, öka förståelsen kring hur eleverna definierar och resonerarThis essay is a qualitative action study that through interviews studies how teachers and students in an aesthetics program in highschool defines and thinks about the term “personal expression” and what the student should do to meet the expectations for fulfilling the requirements concerning that particular grade. The purpose is to increase the knowledge about what differences and similarities the
This master’s thesis is about public libraries and how the work they do for children and youth in the summer holidays relates to public policy and reading research. Triangulation of methods is used with literature review, policy analysis, questionnaire survey and interviews. My primary theoretical framework is Carol Bacchi’s ’What’s the problem represented to be’ (WPR) approach, which is also us
This research analyses the presence of political personalisation and its role in establishing performed authenticity in political content on TikTok. Despite TikTok being a platform created for entertainment purposes, TikTok has come to play a significant role in political discourse and engagement with politicians Employing a qualitative approach to Multimodal Critical Discourse Analysis, this rese
As the population increases, so does the need for residential buildings, offices, schools and preschools. The construction industry accounts for about 20% of Sweden’s greenhouse gas emissions. While buildings become more energy-efficient the focus is shifted from the operational phase to the construction phase. The law on climate declaration is a Swedish law, which holds developers responsible for
Colorectal cancer is the third most common type of cancer, and the second leading cause of cancer-related deaths in the Western world. Chronic inflammation, such as inflammatory bowel diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. They are ligands to the G-protein coupled receptors CysLT1R and CysLT2R, of which CysLT1R
Purpose: Glucose concentrations are elevated in retinal cells in undiagnosed and in undertreated diabetes. Studies of diabetic patients suggest that retinal function adapts, to some extent, to this increased supply of glucose. The aim of the present study was to examine such adaptation in a model of type 2 diabetes and assess how the retina responds to the subsequent institution of glycemic contro
KRAS mutations are major factors involved in initiation and maintenance of pancreatic tumors. The impact of different mutations on patient survival has not been clearly defined. We screened tumors from 171 pancreatic cancer patients for mutations in KRAS and CDKN2A genes. Mutations in KRAS were detected in 134 tumors, with 131 in codon 12 and only 3 in codon 61. The GGT>GAT (G12D) was the most fre
Objective In contrast with the wealth of data on ischaemic heart disease in rheumatoid arthritis (RA), data on stroke are scarce and contradictory. Despite the high clinical and aetiological relevance, there is no data regarding when (if ever) after RA diagnosis there is an increased risk. Our objective was to assess the risk of stroke (by subtype) in contemporary patients with RA, particularly in
FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. Here, we evaluated FKBPL's prognostic ability in primary breast cancer tissue, represented on tissue microarrays (TMA) from 3277 women recruited into five independent retrospective studies, using immunohistochemist
In the present study, a simple and reliable antioxidant screening technique based on lactate dehydrogenase (LDH) oxidation by Cu2+-mediated Fenton's reaction has successfully been developed. Oxidation of LDH by hydroxyl radical consequently leads to enzymatic inactivation, while addition of antioxidants can protect and regain enzyme activity. This method demonstrated a high feasibility on detectin
Background and purpose Hemiarthroplasty as treatment for femoral neck fractures has increased markedly in Sweden during the last decade. In this prospective observational study, we wanted to identify risk factors for reoperation in modular hemiarthroplasties and to evaluate mortality in this patient group. Patients and methods We assessed 23,509 procedures from the Swedish Hip Arthroplasty Registe
BACKGROUND AND PURPOSE: Differences in risk factor profiles between lacunar and other ischemic stroke subtypes may provide evidence for a distinct lacunar arteriopathy, but existing studies have limitations. We overcame these by pooling individual data on 2875 patients with first-ever ischemic stroke from 5 collaborating prospective stroke registers that used similar, unbiased methods to define ri
