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Background The cholinesterase inhibitor donepezil is used to treat mild-to-moderate Alzheimer's disease. Its efficacy in severe dementia has not been assessed and is controversial. Our aim was to ascertain the effectiveness of donepezil in patients with severe Alzheimer's disease, by focusing primarily on cognition and activities of daily living. Methods We did a 6-month, double-blind, parallel-gr
The spawning behaviour of wild caught brood stock as well as early egg and larval development were studied in yellowtail kingfish (Seriola lalandi). Spawning occurred naturally in the austral spring/summer (November–February) when the seawater temperature was above 17 °C. Courtship behaviour involved one male and female, and consisted of a high-speed pursuit punctuated by stalling, nipping and tou
Objective. - To study the impact of preschool outdoor environments on children's physical activity and solar ultraviolet (UV) exposure at different latitudes and countries. Methods. Outdoor environments of 11 preschools (two in Raleigh NC, USA, Lat.36 degrees N, nine in Malmo, Sweden, Lat.55 degrees N) were scored (OPEC) regarding space, vegetation, hilly terrain and level of integration between o
Objectives Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma
Atrial septal defect (ASD) is the most common congenital heart malformation diagnosed in adult life. In this thesis important clinical, haemodynamic and electrophysiological aspects of ASD in the adult are explored. The diagnostic accuracy of magnetic resonance velocity mapping (MRvm)in calculating the pulmonary/systemic flow ratio (QP/QS)was assessed (I). The mean and maximal error by MRvm was 1
Background The perception of surgery as expensive and complex might be a barrier to its widespread acceptance in global health efforts. We did a systematic review and analysis of cost-effectiveness studies that assess surgical interventions in low-income and middle-income countries to help quantify the potential value of surgery. Methods We searched Medline for all relevant articles published betw
Background: More than 90 immunologically distinct serotypes of Streptococcus pneumoniae exist, and it is not fully elucidated whether the serotype is a risk factor for severity of invasive pneumococcal disease (IPD). Our hypothesis is that serotypes differ in their capacity to cause septic shock. Methods: We performed a retrospective study in Southern Sweden based upon 513 patients with IPD in the
Active surveillance of invasive group A streptococcal (GAS) infections was conducted in Denmark during 2003 and 2004 as a part of the Strep-EURO initiative. The main objective was to improve understanding of the epidemiology of invasive GAS disease in Denmark. During the 2 years, 278 cases were reported, corresponding to a mean annual incidence of 2.6 cases per 100,000 inhabitants. The vast majori
Objective: To evaluate the results of the expanded National Venous Screening Program (NVSP) as administered by the American Venous Forum. Methods. Eighty-three physicians across 40 states participated in screening Americans for venous disease. The NVSP instrument included demographics, venous thromboembolism (VTE) risk assessment, quality-of-life (QOL) assessment, duplex ultrasound scan for reflux
BACKGROUND: Associations between cadmium (Cd) and kidney function have been reported even at low levels of exposure in the general population. Recently, the causality of these associations has been questioned. OBJECTIVES: We examined associations between urinary Cd (U-Cd; a biomarker of exposure) and urinary proteins that are used as biomarkers of kidney effects, based on repeated short-term sampl
I EU omfattar den offentliga upphandlingen årligen 1500 miljarder Euro, vilket motsvarar ungefär 16 % av EU:s BNP. Motsvarande siffra i Sverige är uppskattningsvis 400 miljarder SEK. Det finns alltså stora skäl att reglera denna typ av upphandling för att säkerställa att EG-rättens grundprinciper, dvs. principen om likabehandling, principen om icke-diskriminering (på grund av nationalitet), propor
Even if much is known regarding the effects of internet-delivered cognitive behaviour therapy (ICBT) for depression there are several topics that have not been studied. In this factorial design trial with 197 participants we investigated if clients in ICBT could select treatment modules themselves based on a selection of 15 tailored treatment modules developed for use in ICBT for depression. We co
Objective: Degenerative orthopedic diseases (DODs) such as osteoporosis, osteoarthritis, spondylosis, spinal stenosis, and disc herniation are common disorders. Both common and rare genetic risk factors may contribute to DODs, but few large-scale whole-exome sequencing studies elucidating the contribution of rare variations to DODs have been published. The updated version of the Astra Zeneca porta
Time-of-flight mass-spectrometry (TOF-MS) measurements of 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([EMIM][OTF]) vapors have been conducted in order to gain insight into the VUV (vacuum ultraviolet) absorption thresholds. The experimental data were interpreted with hybrid density-functional theory (DFT), time-dependent DFT (TD-DFT), and several flavours of many-body perturbation theor
OBJECTIVES: We assessed the prevalence of neurodevelopmental disabilities (NDDs; cognition, cerebral palsy, vision/hearing, epilepsy), attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), developmental coordination disorder (DCD), behavior problems, and multimorbidity in a national cohort of children born extremely preterm (EPT, <27-week gestation) to provide a comprehe
AIMS: To investigate the prevalence of diastolic dysfunction and associated risk factors in pre-diabetes and diabetes in the general population.METHODS: Diastolic function was assessed by transthoracic echocardiography in a cross-sectional sample of 3840 men and women aged 50-64 years from the Swedish CArdioPulmonary bioImage Study. Anthropometry, medical history, blood pressure, biochemistry and
The main aim of this study was to apply and compare two GIS-based data mining models, namely support vector machine (SVM) by four kernel functions (linear-SVM, polynomial-SVM, radial basic function-SVM, and sigmoidal-SVM) and entropy models in landslide susceptibility mapping, in Shangzhou District, China. Initially, 145 landslide locations were mapped using early reports, aerial photographs, and
The aim of this thesis is to answer the question whether the Swedish Ozone Regulation still is applicable. Hereinafter called the Swedish Ozone Regulation. The reason for this question was a verdict from the Swedish Environmental Court of Appeal Translation of the Swedish Miljööverdomstolen. (The Swedish Court) stating that predominant reasons indicate that the Swedish Regulation no longer is poss
Enligt svenska skattebestämmelser beskattas investeringsfonder olika beroende på om de är svenska eller utländska. För en svensk investeringsfond är mottagen utdelning enligt huvudprincipen skattepliktig. Dock får utdelning som fonden lämnar dras av som kostnad, vilket gör att de utdelningar fonden får i princip blir skattefria om fonden ''skickar vidare'' vinsten till ägarna. En u
Populärvetenskaplig sammanfattning: Kolcykeln är enkelt uttryckt den globala balansräkningen av kolets (C) förflyttning genom olika sfärer såsom mellan atmosfären och biosfären, således är kolcykeln av stor betydelse för mänsklighetens existens. Exempelvis har atmosfäriska koncentrationer av koldioxid (CO2) och metan (CH4) ökat de senaste 200 hundra åren på grund av mänskliga aktiviteter (till stoCarbon is central to our existence. It plays a fundamental role in the carbon cycle. Atmospheric concentrations of carbon dioxide (CO2) and methane (CH4) have been increasing for about two centuries as a result of human activities. The need to understand how carbon cycles through the Earth-system is important for a variety of reasons, but mainly in order to assess the effects of these rising green
