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Objective Systemic sclerosis Impact of Disease (ScleroID) is the first comprehensive patient-reported outcome measure (PROM) specifically developed for systemic sclerosis (SSc). We investigated the performance of ScleroID in patients with diffuse cutaneous SSc (dcSSc), as a prerequisite for its use in randomised controlled trials (RCTs) testing potentially disease-modifying drugs. Methods All pati
Tree roots and their fungal symbionts mediate the response of rhizosphere soil organic carbon (SOC) decomposition to climate warming, specifically the temperature sensitivity of soil microbial respiration (Q10), which is a critical parameter for projecting the magnitude of terrestrial soil C-climate feedbacks. However, the intensity of the rhizosphere effects (RE; rhizosphere soils vs. bulk soils)
Exposure to diesel exhaust is associated with increased risk of cardiovascular and lung disease. Substituting petroleum diesel with renewable diesel can alter emission properties but the potential health effects remain unclear. This study aimed to explore toxicity and underlying mechanisms of diesel exhaust from renewable fuels. Using proximity extension assay (Olink), 92 proteins linked to inflam
Communication is not always easy. There are several different aspects within technical areas that need to be taken into account when communicating between different platforms. Older systems sometimes want to communicate with newer systems which requires older technology to meet more modern technology. This thesis focuses on an older system that needs to communicate with modern interfaces. The goal
Extracting speaker-dependent paralinguistic information out of a person's voice, provides an opportunity for adaptive behaviour related to speaker information in speech processing applications. For instance, in audio-based conversational applications, adapting responses to the attributes of the correspondent is an integral part in making the conversations effective. Two speaker attributes that hum
Continuous water-table (WT) measurements from peatlands are scarce and – if existing at all –very short. Consequently, proxy indicators are critically needed to simulate hydrological changes in peatlands over longer time periods. In this study, we demonstrate that tree-ring width (TRW) records of Scots pine (Pinus sylvestris L.) growing in the Čepkeliai peatland (southern Lithuania) can be used as
Background: In stage I/II natural killer (NK)/T-cell lymphoma, concurrent chemoradiotherapy (CCRT) had previously been shown to result in superior outcome compared with anthracycline-containing regimens, which have since been considered ineffective. The role of CCRT in comparison with approaches employing nonanthracycline-containing chemotherapy (CT) and sequential radiotherapy (RT) in such patien
Yeast volatiles attract insects, which apparently is of mutual benefit, for both yeasts and insects. However, it is unknown whether biosynthesis of metabolites that attract insects is a basic and general trait, or if it is specific for yeasts that live in close association with insects. Our goal was to study chemical insect attractants produced by yeasts that span more than 250 million years of ev
With an ageing population and a discourse of active ageing guiding welfare policies, initiatives to engage older people in health promoting activities have been established. One growing phenomenon is Senior Summer Camps, arranged all over Sweden in beautiful natural environments close to water. Their main purpose is to enable older people to participate in outdoor activities in an institutionalize
QuestionHow do pollen-based functional and phylogenetic diversity help to explain post-glacial vegetation change in relation to climate and human influence? LocationEstonia and Latvia, NE Europe. MethodsWe used a data set of 1062 pollen samples from 20 sites covering the last 14500yrs to estimate plant richness, evenness, functional and phylogenetic diversity (community-weighted mean and mean pair
Climate change is expected to severely affect cropping systems and food production in many parts of the world unless local adaptation can ameliorate these impacts. Ensembles of crop simulation models can be useful tools for assessing if proposed adaptation options are capable of achieving target yields, whilst also quantifying the share of uncertainty in the simulated crop impact resulting from th
To explore the correlation between, and the variation in, various measures of exposure to potential risk factors for work-related upper extremity musculoskeletal disorders (UE-WMSDs), physical workload was measured in 43 types of work (713 individuals), using inclinometry for the head and upper arms, and electromyography (EMG) for the trapezius muscles. Many exposure measures were highly correlate
In this study we quantify the partitioning of recent assimilates to above- and below-ground carbon (C) pools in two subarctic mire ecosystems - wet minerotrophic and semiwet ombrotrophic mire - using in situ C-14 pulse-labelling. Ecosystem C partitioning to rhizomes, coarse roots, fine roots, dissolved organic carbon (DOC) and microbes were quantified twice during the growing season at three diffe
This master’s thesis focuses on the experiences of retired public librarians in relation to their professional life. The public library as an institution and the librarian profession have to this day gone through many changes, and a high level of research has been conducted regarding this. Yet, there is a lack of perspective from those who have actually lived through and during these changes. Base
AIM: The enzymatic regulation of intramuscular triacylglycerol (TG) breakdown has until recently not been well understood. Our aim was to elucidate the role of hormone-sensitive lipase (HSL), which controls TG breakdown in adipose tissue. METHODS: Isolated rat muscle as well as exercising humans were studied. RESULTS: The presence of HSL was demonstrated in all muscle fibre types by Western blotti
Background: L-DOPA-induced dyskinesia is attributed to opposite activity changes mediated by D1 and D2 dopamine receptors in the two striatal output pathways. Whereas the causal role of direct-pathway D1 receptors is well established, the specific involvement of indirect-pathway D2 receptors in dopaminergic dyskinesias has remained elusive. Objectives: We used conditional knockout approaches in mi
Welding fumes were recently classified as carcinogenic to humans and worldwide millions work as welders or perform welding operations. The purpose of this study was to identify new biomarkers of welding-induced carcinogenesis. We evaluated a panel of 91 putative cancer-related proteins in serum in a cohort of welders working with mild steel (n = 77) and controls (n = 94) from southern Sweden sampl
Introduction: Immune complexes are of importance in systemic lupus erythematosus pathogenesis, and autoantibodies are believed to participate in immune complex formation. Quantification of autoantibody levels in circulating IC might be of prognostic value. Methods: A C1q-binding-eluting technique was applied to purify immune complexes from 55 belimumab-treated systemic lupus erythematosus patients
The introduction of the euro as a currency in physical existence in January 2002 was a major step in the European integration process. The purpose of this paper is to explore how a representative selection of 12 000 Europeans across all countries in the euro area view the effects of the euro five years after its introduction. The empirical analysis uses multinomial logistic regressions to explore
The human brain is a complex and finely tuned organ, constantly monitored and maintained by its resident immune cells.Among these, microglia are the primary regulators of the brain immune environment under physiological conditions, and monocyte-derived macrophages contribute mainly to pathological states such as ischemic stroke and neuronopathic Gaucher’s disease (GD). These two diseases, although
