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Background: Treatment-related white blood cell (WBC) toxicity has been associated with an inferior prognosis in different malignancies, including anal cancer. The aim of the present study was to investigate predictors of WBC grade ≥ 3 (G3+) toxicity during chemoradiotherapy (CRT) of anal cancer. Methods: Consecutive patients with locally advanced (T2 ≥ 4 cm—T4 or N+) anal cancer scheduled for two
New Findings: What is the central question of this study? What are the temporal responses of mitochondrial respiration and mitochondrial responsivity to insulin in soleus muscle fibres from mice during the development of obesity and insulin resistance? What is the main finding and its importance? Short- and long-term feeding with a high-fat diet markedly reduced soleus mitochondrial respiration an
Myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MRTFA, and MRTF-B/MRTFB) are co-factors of serum response factor (SRF) that activate the smooth muscle cell (SMC) gene program and that play roles in cardiovascular development and mechanobiology. Gain and loss of function experiments have defined the SMC gene program under control of MRTFs, yet full understanding of their imp
Aim: MicroRNAs (miRNAs) regulate β-cell function, and β-cell mitochondria and insulin secretion are perturbed in diabetes. We aimed to identify key miRNAs regulating β-cell mitochondrial metabolism and novel β-cell miRNA-mitochondrial pathways. Methods: TargetScan (http://www.targetscan.org/) was used to predict if 16 miRNAs implicated in β-cell function target 27 cis-eGenes implicated in mitochon
The human host defense peptide LL-37 has an essential role in the first line of defense against invading pathogens. This cathelicidin is mainly produced by immune cells and epithelial cells aligning the mucosal areas and is normally upregulated upon infection and inflammation. LL-37 displays direct antimicrobial activity against a variety of pathogens, but also modulates the immune responses by ac
Anterior cruciate ligament (ACL) trauma often occurs in combination with injury to the articular cartilage of the knee, this can result in earlier radiographic evidence of post traumatic osteoarthritis (OA) of the knee compared to the contralateral, ACL intact knee; however, the biomechanical and biological mechanisms associated with the onset and progression of this disease are not understood. We
Ectomycorrhizal fungi (EMF) are important components of soil microbial communities, and EMF biomass can potentially increase carbon (C) stocks by accumulating in the soils as necromass and producing recalcitrant structures. EMF growth depends on the C allocated belowground by the host trees, and the nutrient limitation on tree growth is expected to influence this allocation. Therefore, studying EM
Background: The migratory process in birds consists of alternating periods of flight and fueling. Individuals of some populations make few flights and long stopovers, while others make multiple flights between short stopovers. Shorebirds are known for executing marathon flights (jumps), but most populations studied are long distance migrants, often crossing major barriers and thus forced to make l
In today’s highly competitive market place it is of great importance for companies to deliver reliable products while decreasing the development time and costs. The time to market is a driving force for many companies, and throughout the engineering design process as well as the manufacturing process, the focus is on finding timesaving actions. However, the search for timesaving actions will most
Till skolan kommer elever med olika förutsättningar för sitt lärande. För en del elever är den ordinarie undervisningen inte tillräcklig för att nå uppsatta läromål. Inom den s.k. särskilda elevstödjande verksamheten kan skolan vidta åtgärder för elever som är i behov av extra stöd i lärandet. Inom sådan verksamhet kan uppgifter vara av allt ifrån integritetskänslig till harmlös karaktär. OffentStudents come to school with different settings for their learning. For some students the regular teaching is not sufficient to achieve the set learning goals. In the so-called special student support activities (Sw. särskild elevstödjande verksamhet), the school can take action for students who are in need of extra support in their learning. Within such activities, data can range from sensitive t
Syftet med uppsatsen var att få kunskap om hur livssituationen ser ut för de funktionshindrade ungdomar som inte genomgått sin gymnasieutbildning på riksgymnasiet. Mitt intresse riktade sig mot ungdomarnas egen syn på sin situation. Syftet var att utifrån deras berättelser om sig själva och sina upplevelser beskriva hur deras gymnasieutbildning blev och hur den fört dem till den situation de befin
I svensk rätt gäller som huvudregel att ett avtal endast är bindande mellan parterna. Så är fallet även vad gäller skiljeavtal. Vissa typsituationer, till exempel singularsuccession och borgen, kan ge upphov till frågan om någon som inte skrivit under ett skiljeavtal (en icke-signatär) trots allt är skiljebunden. En följdfråga som uppstår är om icke-signatärens skiljebundenhet förutsätter att ickeUnder Swedish law, an agreement is in principle binding only between the parties. This also applies to arbitration agreements. However, in certain typical situations, such as party substitution by way of singular succession and guarantee liability, the question arises as to whether a non-signatory to the arbitration agreement is bound by it. A related issue is whether a non-signatory may be bound
The CSDDD, the EU’s mandatory due diligence directive, is a landmark addition to the EU’s corporate sustainability framework that transforms previously voluntary norms into binding law. Its mandatory due diligence obligations require companies to identify, assess, and address adverse human rights and environmental impacts in their chain of activities, both within and outside the EU. The aim is to
Muntlig bevisning har länge medfört problem i den svenska hovrätten. När ett mål når den andra instansen har kvaliteten på muntlig bevisning blivit sämre, inte minst på grund av att minnesbilder hos förhörspersoner försvagas med tiden. Trots det har utgångspunkten, allt sedan det muntliga och omedelbara förfarandet introducerades genom 1948 års rättegångsbalk (RB), varit att principen om det bästaOral evidence has caused problems in the Swedish courts of appeals for a long time. When a case reaches the higher court, the quality of oral evidence has deteriorated, primarily because the recollections of witnesses and parties have weakened over time. The starting point has, nevertheless, been that the principle of the best evidence requires renewed questioning of witnesses and parties in the c
A risk evaluation with regards to fire safety has been performed at Torpa Stenhus. The focus of the evaluation was the safety of the people inside the building in case of a fire. As part of the education for future fire protection engineers at LTH a risk evaluation report is performed in the course Brandteknisk riskvärdering (VBR054). Torpa Stenhus was built during the 15th century and is located
Aging profoundly affects the immune system leading to an increased propensity for inflammation. Age-related dysregulation of immune cells is implicated in the development and progression of numerous age-related diseases such as: cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. Monocytes and monocyte-derived macrophages, being important players in the inflammatory resp
BACKGROUND: Several widely used drugs have photosensitizing properties, and much research has been conducted to find associations between their use and the risk of developing cutaneous malignant melanoma (cM), basal cell carcinoma (BCC) or cutaneous squamous cell carcinoma (cSCC), often with conflicting results.OBJECTIVE: To assess whether the use of commonly prescribed photosensitizing drugs incr
PurposeLeucine rich alpha-2 glycoprotein 1 (LRG1) has emerged as a promising biomarker for appendicitis, especially in pediatric patients. However, the currently available data are sparse, and the biomarker must be validated in more settings and compared to standard inflammatory markers. We aimed to evaluate the diagnostic and discriminative utility of serum and urine LRG1 in children with other c
INTRODUCTION: Tourette syndrome (TS) and chronic motor or vocal tic disorder (CTD) are neurodevelopmental disorders associated with functional impairment and reduced quality of life. Behavioral therapy (BT) is an effective treatment, but lack of experienced practitioners makes it hard for patients to receive appropriate help. One approach to bridge the gap between demand and availability is to off
In the Swedish context, ‘intergenerational Collaborative Housing’ and ‘Collaborative Housing for the second half of life’ (CH2L), based on the self-work model, were developed in the 1980s and 1990s. The chapter examines how ageing individuals developed caring practices and mutual support strategies in these collective housing forms and how such practices were adapted during the COVID-19 pandemic.
