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In type I diabetes mellitus (T1DM), the frequency of antibodies against insulin (IAA), glutamic acid decarboxylase-65 (GAD65), ICA512/IA2 (IA2), and islet cell antigens (ICA) vary with human leukocyte antigen (HLA) composition of the patient. IAA, IA2 autoantibodies, and ICA are increased in DQ8 positives; GAD65 antibodies are increased in DQ2 positives. MHC class I chain-related gene-A (MICA) is
Popular Abstract in Swedish Laser Doppler metoder avsedda för mätning av blodflöde baserar sig på det faktum att fotoner skiftar i våglängd när de träffar blodkroppar i rörelse. Den förändrade våglängden registreras och signalen bearbetas varefter resultatet uttrycks i en godtycklig enhet och anses utgöra ett mått på blodflöde. Laser Doppler Perfusion Monitoring (LDPM) är en metod med vilken blodThe operating principle of all laser Doppler methods is based on the fact that incident photons shift in wavelength when interacting with moving blood cells passing through the microvascular network. After photodetection and further signal processing, the recorded parameter can be considered an arbitrary measure of tissue blood flow, and this is referred to as ?perfusion?. Laser Doppler perfusion
Popular Abstract in Swedish Den moderna epokens början återfinns i det sena sjuttonhundratalet och i Europa. Det är en epok, en kultur som förstår sig som både ny och som annorlunda i förhållande till tidigare epoker och kulturer, sådana som vilat på myter, religion och tradition. Den nya kulturens fundamentala insikt bestod i att ingenting måste vara så som det är, utan allt vore möjligt också påThe problem which the present study discusses is modernity. The study interprets modernity’s cultural and anthropological dispositions as historical appearances. Consequently, it is situated at the intersection of cultural sociology and historical anthropology. The aim is to generate insight and understanding rather than a coherent theory. The key element consists of combination and variation of c
Popular Abstract in Swedish Denna skrift behandlar marklagring av värme, kyla och kärnavfall.The underground is a vast region, which is, too a large extent, unused by man. It has a large potential as a storage facility due to its vastness and availability. This thesis, which consists of eleven papers and reports, deals with nuclear waste repositories in solid rock and with aquifer thermal energy storage systems. All these storage systems induce multidimensional, time-variable thermo-hydr
In this thesis a simulation model is presented that enables a comparison of different hybrid topologies, with respect to fuel consumption, emissions and performance. The obtained results stress the properties of the different topologies and form a foundation for the choice of hybrid topology. The simulation models included in this thesis are the result of collaboration with Petter Strandh at the D
In advanced stages of Parkinson's disease, serotonergic terminals take up l-DOPA and convert it to dopamine. Abnormally released dopamine may participate in the development of l-DOPA-induced dyskinesias. Simultaneous activation of 5-HT1A and 5-HT1B receptors effectively blocks l-DOPA-induced dyskinesias in animal models of dopamine depletion, justifying a clinical study with eltoprazine, a 5-HT1A/
Renegotiations: Body, Line, Ethics departs from questions concerning authorship and agency for actors in institutionalised settings and moves towards a discussion on ethics, responsibility and possibilities in the body – text relationship. The question of how bodies can be renegotiated in and by the theatrical line is central to the work. Against a backdrop of previous and other stage productions
Introduction: Previous studies have shown that the injection of adipose tissue–derived stem cells (ADSCs) into the tunica albuginea (TA) during the active phase of Peyronie's disease (PD) prevents the development of fibrosis. Aim: To investigate, using an animal model, whether local injection of human ADSCs (hADSCs) can alter the degree of fibrosis in the chronic phase of PD. Methods: 27 male, 12-
It is well known that marine fish dynamics relate with climate variability, and predicting future population developments have become increasingly urgent with on-going climate change. One approach in widespread populations is to study how individuals from different parts of the distribution area respond to climate, thereby testing for potential resilience in terms of local adaptions against enviro
Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women.This thesis investigated biological events in ovarian cancer, which were translated into clinically relevant observations using differ
Part of the justification for an integrated view of speech and gestures ( (( is their temporal coordination. Gestures generally coincide with or precede, but rarely follow lexical affiliate (McNeill, 1992). How synchrony impacts listeners remains less explored, despite potential relevance for video communication and virtual conversational agents. ERP studies suggest that temporal alignment affects
Background: Among pediatric patients, newborns are at highest risk of developing thromboembolism. Neonatal thromboembolic (TE) events may consist of both venous and arterial thromboses and often iatrogenic complications (eg, central catheterization). Treatment guidelines for pediatric patients with TE events most often are extrapolated from the literature regarding adults. Options for the manageme
PURPOSE: Mutations of PCDH15, the gene encoding protocadherin 15, cause either nonsyndromic deafness DFNB23 or Usher syndrome type 1F (USH1F) in humans and deafness with balance problems in Ames waltzer (av) mice. Persons with USH1 usually begin to exhibit signs of retinitis pigmentosa (RP) in early adolescence, but av mice are reported to have functional retinas. In this study, the auditory, visu
There are excellent guidelines for clinicians to manage venous diseases but few reviews to assess their hemodynamic background. Hemodynamic concepts that evolved in the past have largely remained unchallenged in recent decades, perhaps due to their often complicated nature and in part due to emergence of new diagnostic techniques. Duplex ultrasound scanning and other imaging techniques which evolv
Global gridded crop models (GGCMs) combine agronomic or plant growth models with gridded spatial input data to estimate spatially explicit crop yields and agricultural externalities at the global scale. Differences in GGCM outputs arise from the use of different biophysical models, setups, and input data. GGCM ensembles are frequently employed to bracket uncertainties in impact studies without inv
The Arctic is exposed to even faster temperature changes than most other areas on Earth. Constantly increasing temperature will lead to thawing permafrost and changes in the methane (CH4) emissions from wetlands. One of the places exposed to those changes is the Abisko-Stordalen Mire in northern Sweden, where climate and vegetation studies have been conducted since the 1970s. In our study, we anal
OBJECTIVE: In Huntington's disease (HD), the disease-causing huntingtin (HTT) protein is ubiquitously expressed and causes both central and peripheral pathology. In clinical HD, a higher body mass index has been associated with slower disease progression, indicating that metabolic changes may be involved in disease pathogenesis. Underlying mechanisms of metabolic changes in HD are not fully known,
Denna forskningsöversikt är en sammanställning av de europeiska vetenskapligastudier som innehåller empirisk evidens när det gäller om och hur honungsbinpåverkar vilda bin genom att konkurrera om födoresurser. Sammanställningengår igenom i vilken mån honungsbins och vilda bins födoval överlappar.Dessutom redovisas i vilken mån studierna visar att honungsbin har effekt påvilda bins blombesök och reCompetition from honey bees on wild bees – effects, knowledge gaps and possible interventions.In this review, we have compiled the European emp irical evidence available in the scientific literature on the effects of honey bees on wild bees through competition for food resources. We have also inventoried ongoing initiatives in northern Europe concerning competition between honey bees and wild bees
