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The dendritic cell (DC) lineage encompasses a diverse population of cells with unique subtype-specific functions. In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses. However, their respective roles in allergic diseases, such as rhinitis, are unclear.
Our presentation builds on a research project on the emergence of medical genetics and genetic counselling in Sweden 1940-1980. During our study, we have been able to track some aspects of biological, or eugenic, citizenship throughout this period.In Sweden, a rudimentary form of genetic counselling can be tracked within the context of state-controlled eugenics, namely in some applications of the Our presentation builds on a research project on the emergence of medical genetics and genetic counselling in Sweden 1940-1980. During our study, we have been able to track some aspects of biological, or eugenic, citizenship throughout this period.In Sweden, a rudimentary form of genetic counselling can be tracked within the context of state-controlled eugenics, namely in some applications of the
An increasing amount of people living under the control of armed groups begged the question on the human rights obligations by armed groups in situation of protracted armed conflict. Traditionally, international human rights treaties only impose obligations on states. This raises concerns about the protection vacuum as well as accountability of the armed groups. A new phenomenon also emerged where
Experimental data on single file pedestrian movement has been analysed andimplemented in a prototype movement model. The prototype model is developed topredict movement of persons based on a first principle approach using basic populationdata such as age, height, gender and response time to adapt the walking speed in a crowd.The experimental data provide the biomechanical information needed in the
IgE is responsible for type 1 mediated allergic reactions, affecting an increased part of the European population. Even though a large part of the population is affected, further being an economical burden for society, little is known about the human IgE repertoire. Variation in antibodies are mainly found in antibody variable domains, and gained understanding of the IgE repertoire can be obtained
Background: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acu
Background: Acupuncture is used for clinical pain relief but has not been evaluated under clinical anaesthesia. This study was designed to compare movement in response to surgical incision in anaesthetized patients subjected to electro-acupuncture (EA) or sham procedures. Our hypothesis was that EA stimulation would reduce the requirements for anaesthetic gas. Methods: Forty-six healthy women, sc
Background: Vitamin A supplementation (VAS) at birth has been associated with decreased mortality in Asia. Bacille Calmette-Guerin (BCG) vaccine is given at birth in tuberculosis-endemic countries. Previous studies suggest that VAS may influence the immune response to vaccines. Objective: Our objective was to examine whether VAS influences the immune response to simultaneously administered BCG vac
René Descartes’ Meditations on First Philosophy explores foundational philosophical and theological questions through a method of radical skepticism. Central to this exploration is the concept of the evil demon, a hypothetical being that challenges human capacity to comprehend and perceive reality. Descartes’ meditations are pivotal to the development of rationalist philosophy, bridging epistemolo
The principle of ne bis in idem, enshrined both in the Charter of Fundamental Rights of the European Union and in the European Convention on Human Rights, has been the object of an extensive body of case law. Therefore, the question this thesis seeks to answer is: ‘what is the current status of the principle of ne bis in idem under EU tax law?’ After the development of a high level of protection r
Purpose:The purpose of this study is to map different kinds of tensions in product innovation and investigate how top managers use communication to shape subordinates' attention and thereby respond to these tensions.Design/methodology/approach:This study adopted an embedded case study of four innovation centers within a Nordic multinational firm.Findings:This study identifies three kinds of tensio
Disturbances play a key role in forest dynamics globally, with various effects on productivity. Tree diversity is expected to attenuate the negative impact of disturbance on forest productivity, but its overall effect has been little explored and might depend on the functional composition. Here, we analysed whether forest productivity responses to disturbances were modulated by structural and func
Maturation of dendritic cells (DC) serves a deterministic role in the link between innate and adaptive immunity, constituting a checkpoint with regard to whether responses from the lymphocyte compartment shall be raised and what class of response is needed to protect the host against invading pathogens. Since DC have not been shown to possess mechanisms such as gene recombination or somatic mutati
Background and purpose: Rat stomach ECL cells secrete histamine and pancreastatin in response to gastrin and pituitary adenylate cyclase-activating peptide-27 ( PACAP). This study applies microdialysis to explore how ECL cells in situ respond to PACAP and gastrin. Experimental approach: Both peptides were administered by microinfusion into the gastric submucosa. The microdialysate was analysed for
