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https://www.lu.se/evenemang/child-rights-institute-lecture-harry-shier - 2026-07-10

https://www.lu.se/evenemang/ig-nobel-euro-tour-i-lund - 2026-07-10

CD40-stimulating immunotherapy can elicit potent anti-tumor responses by activating dendritic cells and enhancing T-cell priming. Tumor vessels orchestrate T-cell recruitment during immune response, but the effect of CD40-stimulating immunotherapy on tumor endothelial cells has not been evaluated. Here, we have investigated how tumor endothelial cells transcriptionally respond to CD40-stimulating

BACKGROUND: Malignancies of the liver and bile ducts are associated with high recurrence rates after surgery and poor prognosis when disseminated. Medical treatment has been improved in recent years, with chemotherapy, targeted therapy and checkpoint inhibitors offering opportunities to influence the course of the diseases. Many patients do not benefit from treatment, however, and predictive and p

Protein dynamics are essential to biological function, and methods to determine such structural rearrangements constitute a frontier in structural biology. Synchrotron radiation can track real-time protein dynamics, but accessibility to dedicated high-flux single X-ray pulse time-resolved beamlines is scarce and protein targets amendable to such characterization are limited. These limitations can

In vitro growth hormone (GH) stimulation of Janus kinase 2 (Jak2) tyrosine phosphorylation and activation has been detected in rat adipocytes where GH exerts both chronic diabetogenic and acute insulin-like effects but not in adipocytes where only chronic diabetogenic effects are exerted. The 95 kDa transcription factor Stat5, which is tyrosine phosphorylated in response to GH in both cases, is he

This study goes beyond attitudes and behavioral indications as response to risk perceptions and focuses on actual behavior of laypeople. We report the results from a survey, conducted among a sample of Swedish citizens in the spring of 2009, looking at lay actions as responses to the financial crisis of 2008. In total, 3138 respondents were asked whether they had done something to protect their mo

Domestic mallards (Anas platyrhynchos domesticus) are traditionally used as a model to investigate infection dynamics and immune responses to low pathogenic avian influenza viruses (LPAIVs) in free-living mallards. However, it is unclear whether the immune response of domestic birds reflects the response of their free-living counterparts naturally exposed to these viruses. We investigated the exte

Climate change is predicted to alter global precipitation regimes. However, the response of soil carbon and nitrogen cycles and soil microorganisms to precipitation reduction is poorly understood but is dependent on ecosystem type. To evaluate the impacts of reduced precipitation on soil respiration, soil inorganic nitrogen (i.e., NH4+–N and NO3−–N), nitrogen mineralization, and soil microbial com

Introduction: Allergen exposure worsens viral-triggered asthma exacerbations and could predispose the host to secondary bacterial infections. We have previously demonstrated that exposure to house dust mite (HDM) reduced TLR-3-induced IFN-β in human bronchial epithelial cells (HBECs) from healthy donors. We hypothesize that HDM sensitization in different ways may be involved in both viral and bact

This article is a response to the recent work of Michael F. Bird and Michael R. Whitenton, in which they argue that Hippolytus's De Christo et Antichristo provides a clear instance of a subjective genitive construction and unambiguously identifies as Jesus' death on the cross. However, in light of (1) a significant textual variant, and (2) the role that plays in Hippolytus's theology of martyrdom,

To evaluate potential long-term effects of climate change and atmospheric nitrogen (N) deposition on subalpine ecosystems, the coupled biogeochemical and vegetation community competition model ForSAFE-Veg was applied to a site at the Loch Vale watershed of Rocky Mountain National Park, Colorado. Changes in climate and N deposition since 1900 resulted in pronounced changes in simulated plant specie

Community resilience is a highly relevant topic and the focus of much contemporary research, however it has yet to be distilled down to an exact science. The current thesis applies a theoretical framework for community resilience as an analytical lens when investigating the community response to the Grenfell fire and tragedy of 14th June 2017. Of particular interest is to uncover what community re

Background: Infections trigger complex immune responses, with conserved as well as disease-specific characteristics. Methods: Proteomic screening technology and gene expression analysis were used here to define the immune response in infants, with their first episode of febrile urinary tract infection. Urine and peripheral blood samples were obtained at enrollment and at follow-up, after 6 months.