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PURPOSE: Reliable molecular diagnostic tools are still unavailable for making informed treatment decisions and monitoring the response in patients with castration resistant prostate cancer. We evaluated the significance of whole blood circulating androgen receptor transcripts of full length (AR-FL) and splice variants (AR-V1, AR-V3 and AR-V7) as biomarkers of abiraterone acetate treatment resistan
The objective of this study was to correlate the relative transcription of Listeria monocytogenes (strains C5, 6179) stress- (gad2, sigB) and virulence- (prfA) associated genes following habituation at twenty-five pH (4.8, 5.0, 5.2, 5.5, 6.4) and NaCl (2, 4, 6, 8, 10% w/v) combinations at 7 °C, with the survival against subsequent exposure to severe acid stress (pH 2.0 at 37 °C). Our findings poin
We found that engagement of beta 2 integrins on human neutrophils increased the levels of GTP-bound Rap1 and Rap2. Also, the activation of Rap1 was blocked by PP1, SU6656, LY294002, GF109203X, or BAPTA-AM, which indicates that the downstream signaling events in Rap1 activation involve Src tyrosine kinases, phosphoinositide 3-kinase, protein kinase C, and release of calcium. Surprisingly, the beta
Purpose: The quality of the study design and data reporting in human trials dealing with the inter-individual variability in response to the consumption of plant bioactives is, in general, low. There is a lack of recommendations supporting the scientific community on this topic. This study aimed at developing a quality index to assist the assessment of the reporting quality of intervention trials
Genetic susceptibility to insulin resistance is associated with lower adiposity in adults. Insulin resistance, and therefore adiposity, may alter sensitivity to Growth Hormone (GH). We aimed to determine the relationship between adiposity, genetic susceptibility to insulin resistance or insulin secretion, and response to GH treatment in short children born small for gestational age (SGA).
The 2011 Great East Japan Earthquake on March 11, 2011 triggered not only giant tsunami waves, but also caused significant land subsidence followed by land rise in the Sendai Coastal Plain areas. These impacts resulted in severe damages to the coastal infrastructure and induced coastal morphology changes along Japan's northeast coast. It was observed that the maximum downward deformation in the Se
Climate warming is driving changes in species distribution, but habitat characteristics can interact with warming temperatures to affect populations in unexpected ways. We investigated wintering waterbird responses to climate warming depending on habitat characteristics, with a focus on the northern boundary of their non-breeding distributions where winter climatic conditions are more extreme. At
This response to Alister McGrath’s The Nature of Christian Doctrine examines the interplay between Scripture, the Rule of Faith, and evolving Christian doctrine and tradition. Focusing on McGrath’s critique of Lindbeck’s presentation of doctrinal modalities, the article explores how doctrinal formation involves primarily synchronic (canonical), but also diachronic (historical), approaches to scrip
Soil erosion has created landscape problems in many parts of the world and in particular in cold regions where the sensitive permafrost conditions have changed due to climate warming. Such a case occurred in the Tibetan Plateau (TP), which has been strongly affected by global warming and human activities. Monitoring technologies, like remote sensing and field surveys were used to explore soil eros
Aims: Patients with left axis deviation (LAD) and left bundle branch block (LBBB) show less benefit from cardiac resynchronization therapy (CRT) compared to other LBBB-patients. This study investigates the reasons for this. Methods: Sixty-eight patients eligible for CRT were included. Patients were divided into groups according to QRS-axis; normal axis (NA), left axis deviation (LAD) and right axi
Det finns två olika vägar till examen. I detta avsnitt fördjupar vi oss i skillnaden mellan att läsa ett program och välja att kombinera fristående kurser. Vi tar också upp hur man får en examen, och ställer oss frågan: Vilken examen är egentligen bäst? Välkomna till studievägledarpodden. Om du tänker söka in på universitet eller högskola för första gången- -och är osäker på vad, hur och varför du
Educational reforms including community-based educational initiatives maintain crucial roles in the processes of democratization in the Middle East. The patterns of reform are diverse and reflect domestic factors as well as varying linkages to global forces. Among the factors driving and defining the effects of reform we find: 1. Socio-economic development;2. Growth of the civil society;3. New modEducational reforms including community-based educational initiatives maintain crucial roles in the processes of democratization in the Middle East. The patterns of reform are diverse and reflect domestic factors as well as varying linkages to global forces. Among the factors driving and defining the effects of reform we find: 1. Socio-economic development;2. Growth of the civil society;3. New mod
PURPOSE: We evaluated whether biennial screening with prostate specific antigen (PSA) only is sufficient to detect prostate cancer while still curable. MATERIALS AND METHODS: In Goteborg, Sweden 9,972 men 50 to 65 years old were randomized to PSA screening. During 1995 and 1996 these men were invited for a first PSA screening and invited during 1997 and 1998 for a second screening. The screening p
Avsikten med denna uppsats har varit att undersöka hur Härskarringen av J.R.R Tolkien har blivit en så pass stark bästsäljare och steady seller under en längre tid. Detta har undersökts genom att studera de litterära värden som presenteras i boken Höstens Böcker och genom att därefter ha genomfört en enkätundersökning, där frågorna varit utformade baserat på dessa litterära värden. Författarna i H
Aurelija LukosevicieneAuthors and Creative UsersAddressing the Conceptual Challenges of Digital Creativity to EU Copyright Law from the Perspective of the AuthorDatum för disputation: fredagen den 1 oktober 2021Fakultetsopponent: Professor Ole Andreas Rognstad, Oslo universitetÄmne: civilrättAbstractTo be an “author” might mean many different things, depending on the context in which the word is u
https://www.jur.lu.se/forskning/disputationer/disputationer-2021 - 2026-07-11
