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The gene for an IgA-binding protein from a group A streptococcal strain was cloned and expressed in Escherichia coli. The IgA-binding protein, called protein Arp, was purified on IgA-Sepharose, allowing complete purification in a single step. Analysis of protein Arp by Western immunoblotting demonstrated a major IgA-binding band, with an apparent molecular weight of 42 kD. The purified protein was

Popular Abstract in Swedish Streptococcus pyogenes (grupp A streptokocker) är en bakterie som orsakar flera olika infektionssjukdomar hos människan, av vilka de vanligaste är halsfluss och svinkoppor. För att kunna infektera sin värd använder sig en patogen bakterie av virulens-faktorer och S. pyogenes uttrycker flera olika sådana. Den viktigaste av dessa anses vara M proteinet som Streptococcus pyogenes (group A Streptococcus) expresses several different virulence factors. Of these, the M protein is regarded as one of the most important, because it confers resistance to phagocytosis, allowing the bacterium to multiply in blood. A remarkable property of M proteins is their ability to bind different human plasma proteins, in partic

Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with

Checklista för uppdragsavtal Forskningsservice Sophie Hydén Picasso Finansieringsmetoder för excellens PLANERA EN AKADEMISK KARRIÄR En akademisk karriär är ofta mångfacetterad, och dess olika delar ställer krav på olika typer av egenskaper och färdigheter. Olika karriärprofiler och vägar framåt kan överlappa och kombineras, alternativt så rör man sig mer etappvis längst karriärvägen. Forskning, un

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/finansieringsmetoder-for-excellens.pdf - 2026-07-22

Utveckl ingsforskni ngens Dag lnverted Viernls of the World 14 oktober 2005, Lunds Universitet P løts : K u lt urg e o g raJîs k ø Instit utío n e n, G e o c e nt r um 1, S ö lve g atan I 0 (samt Sociologiskø Instítutionen, Sölvegatan 7, se parøllellsessionsprogrammet) Tid: 8.30 - 16.30 Program för dagen 10.00- 10.30 * Kaffepaus-postervisningar-bokbord 10.30 - 11.50 * Parallellsessioner à 20 minut

https://www.svet.lu.se/en/sites/svet.lu.se.en/files/2005_programme-drd.pdf - 2026-07-22

Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti

Tim Ingold’s critique of mainstream modern experiences of human–environmental relations is highly persuasive but almost completely disconnected from considerations of social relations of power and inequality. His emphasis on the phenomenology of local relations seems inevitably detached from the logic of abstract economic and political systems. This article proposes that the distortions of experie

Recent studies have highlighted how building resilience to ‘shrinking’ episodes, as opposed to increasing growth rates, appears to be the missing piece of the puzzle when it comes to between-country income convergence. All economies seem to be able to grow, but few countries have been able to drastically improve their shrinking patterns, which has underpinned the divergence often argued in literat

The royal Danish-Norwegian flagship Gribshunden, launched in 1485, was amongthe earliest northern European warships purpose-built to carry artillery. However, King Hans employed his vessel as far more than a weapons platform. The ship was his ‘floating castle’, fulfilling all the various purposes of a land redoubt. At its loss in 1495 enroute to a political summit in Kalmar, where Hans expected to

The royal Danish-Norwegian flagship Gribshunden, launched in 1485, was amongthe earliest northern European warships purpose-built to carry artillery. However, King Hans employed his vessel as far more than a weapons platform. The ship was his ‘floating castle’, fulfilling all the various purposes of a land redoubt. At its loss in 1495 enroute to a political summit in Kalmar, where Hans expected to