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Revised simulation theory (Goldman, 2006) allows mental state attributions containing some or all of the attributor’s genuine, non-simulated mental states. It is thought that this gives the revised theory an empirical advantage, because unlike theory theory and rationality theory, it can explain egocentric bias (the tendency to over attribute ones’ own mental states to others). I challenge this vi
Calcitonin gene-related peptide (CGRP) research was initiated by Poyner et al.,(1) who found that the calcitonin gene encodes the 37-amino acid neuropeptide CGRP in neuronal tissue. Within months, the Lund group produced antibodies toward α-CGRP and developed sensitive methods to study the role of this peptide in the cranial circulation. Intracranial vessels and the trigeminal ganglion harbor this
Label-free LC-MS methods are attractive for high-throughput quantitative proteomics, as the sample processing is straightforward and can be scaled to a large number of samples. Label-free methods therefore facilitate biomarker discovery in studies involving dozens of clinical samples. However, despite the increased popularity of label-free workflows, there is a hesitance in the research community
Smad5 is known to transduce intracellular signals from bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-beta (TGF-beta) superfamily and are involved in the regulation of hematopoiesis. Recent findings suggest that BMP4 stimulates proliferation of human primitive hematopoietic progenitors in vitro, while early progenitors from mice deficient in Smad5 display increa
Since the economic reforms in 1978 the Chinese economy has shown remarkable growth rates. The countries in East Asia all had very high growth rates before they were hit by the economic crisis in 1997. Could the same thing happen to China? The aim of the thesis is to investigate if China is heading for an economic crisis. Based on theories and empirical studies of other economic crises we study the
Granule neurons of the dentate gyrus (DG) of the hippocampus undergo continuous renewal throughout life. Among cell cycle regulators, cyclin-dependent kinase 2 (Cdk2) is considered as a major regulator of S-phase entry. We used Cdk2-deficient mice to decipher the requirement of Cdk2 for the generation of new neurons in the adult hippocampus. The quantification of cell cycle markers first revealed
Sustainable development requires coordination among multi-level actors to achieve set targets, with networks playing a key role in sharing knowledge and fostering collective actions. These networks’ success hinges on member engagement, but since participation is voluntary, members choose their level of involvement. Despite the importance, factors influencing network engagement remain rather scarce
With growing concern over organised crime in Sweden, increased attention has been directed towards children's involvement in escalating violence. Children are portrayed both as victims of coercion and as voluntary participants, reflecting a dual approach in governmental policy. This study investigates how the issue of children's involvement in criminal activities is problematised in three
This research explores young mothers' usage of social media to obtain child-rearing information in mainland China. I interviewed 11 Chinese women with the different background of their everyday social media practices. Through analyzing of their interpretation, the research displays one facet of mediated society, that is how social media influences young Chinese mothers in different aspects, sh
Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. Most FRDA pateints have extended GAA
Brain-derived neurotrophic factor (BDNF) is an important protein for neuroplasticity and neurogenesis. In this thesis the role of BDNF, in suicidal behaviour was investigated with focus on possible risk factors for suicidal behaviour such as avoidant focused coping, dysfuntional personality traits like impulsiveness and hyperactivity of the Hypothalamic-Pituitary-Adrenal (HPA) axis.Paper I: The a
