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There is a high quest for novel therapeutic strategies to enhance recovery after stroke. MicroRNA-124 (miR-124) has been described as neuroprotective and anti-inflammatory molecule. Moreover, miR-124 is a well described enhancer of adult neurogenesis that could offer potentially beneficial effects. Herein, we used miR-124-loaded nanoparticles (miR-124 NPs) to evaluate their therapeutic potential i

Trafikbullers inverkan på sömnen har undersökts medelst EEG-, EOG- och EMG-registreringar på sju unga män (21-27 år) och sex äldre män (63-74 år) i deras vanliga hemmiljö längs hårt trafikerade vägar (trafikintensitet cirka 450 fordonspassager med toppbullernivå överstigande 40 dB (A) per natt). Effekten av dämpning (cirka 10 dB (A)) av inomhusbullret genom montering av ljudisolerande plattor i fö

Although the research on the design of heterogeneous concurrent systems has a long and rich history, a unified design methodology and tool support have not emerged so far. Therefore, the creation of such systems remains a difficult, time-consuming and error-prone process. The absence of principled support for system evaluation and optimization at high level of abstraction makes the quality of the

Fields of Green and Gold är en multipel fallstudie som analyserar placeringen och etableringen av två storskaliga, berömda och påkostade golfanläggningar för att därigenom undersöka den exklusiva golfens politiska ekologi. De fall som studeras är Bro Hof Slott Golf Club i Upplands-Bro - som öppnade 2007 - och Trump International Golf Links Scotland i Aberdeenshire - som öppnade 2012. Att analyseraFields of Green and Gold is a multiple case study analysing the placing and establishment of two large-scale, high-profile, upmarket golf developments with the aim of exploring a political ecology of high-end golf. The cases studied are Bro Hof Slott Golf Club in Upplands-Bro, opened in 2007, and Trump International Golf Links Scotland in Aberdeenshire, opened in 2012. Reading these two cases toge

The concept of Extended Producer Responsibility (EPR) has been underpining recycling/waste/product policy of a number of countries over the past two decades. However, it is considered that the understanding of the concept varies. This presents the findings from a survey conducted in Japan in 2013 to find out the actual perceptions of various stakeholders in Japan. It is part of a global survey con

We demonstrate direct visualization of melting mapping of DNA stretched in nanoscale channels[1] using standard staining methods and epifluorescence microscopy to gain information on the local AT/GC ratio along large DNA molecules. Our development opens up a novel route to mapping of large-scale genomic variations.