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Abstract: The concentrations of cyclic AMP, noradrenaline, glycogen, glucose, lactate, pyruvate, labile phosphate compounds, and free fatty acids were investigated in the rat neocortex and hippocampus during and following cerebral ischemia. An incomplete ischemia of 5 and 15 min duration was induced by bilateral carotid clamping combined with hypotension. The postischemic events were studied after

A detailed light- and electron-microscopic study of the damage to the rat dentate gyrus in hypoglycemia was undertaken, in view of the previously advanced hypothesis that hypoglycemic nerve cell injury is mediated by a released neurotoxin. The distribution of neuronal necrosis showed a relationship to the subarachnoid cisterns. Electron microscopy of the dentate granule cells and their apical dend

The effects of inhaled 1,1,1-trichloroethane (3500, 6000, and 7800 ppm) on behavior, local cerebral blood flow, and local cerebral glucose consumption were studied in awake rats. The effect of the solvent inhalation on the EEG pattern and local cerebral blood flow was also studied in paralyzed animals under N2O analgesia. Exposure of awake animals to 6000 ppm 1,1,1-trichloroethane induced a decrea

The present study aimed to study the relation between the release of arachidonic acid (AA) and the energy state in cerebral cortices of rats during single episodes of cortical spreading depression (CSD). The changes in concentrations of AA, labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)], and glycolytic metabolites (lactate, pyruvate, glucose, and glycogen) were studied durin

OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE).METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each

Importance: This follow-up study of extremely preterm (EPT) children (<27 weeks' gestational age [GA] at birth) revealed major eye and visual problems in 37.9% (147 of 388) of all EPT infants and in 55.4% (67 of 121) of the most immature subgroups at 6.5 years of age. These major eye and visual problems were strongly associated with treatment-requiring retinopathy of prematurity (ROP).Objectives:

Popular Abstract in Swedish Denna avhandling är resultatet av ett doktorandprojekt vid Kvartärgeologiska avdelningen, Lunds Universitet. Syftet med undersökningen var att rekonstruera vegetations-, klimat- och havsnivåförändringar på Skagi-halvön, norra Island, under sen-Weichsel och tidig-Holocen. Nordatlantområdet genomgick en serie dramatiska klimatväxlingar i samband med övergången från den sSediment sequences from five lakes on the Skagi peninsula, northern Iceland, were subjected to mineral magnetic analysis, carbon analysis, pollen analysis, plant macrofossil analysis, diatom analysis, radiocarbon dating and tephra analysis in order to make detailed reconstructions of vegetation, climate and sea level during the Late Weichselian and Early Holocene. The main purpose was to investiga

Det krävs åtgärder på flera nivåer för att minska utsläppsnivåerna från vägtrafiken. I denna uppsats studeras möjligheten att använda förarstöd för att minska den totala bränsleförbrukningen och emissionerna. Detta är gjort med en litteraturstudie som beskriver vad som påverkar bränsleförbrukningen och utsläpp av emissioner generellt, ur ett förarperspektiv samt vid användning av förarstöd med mil

Objective To compare, in young active adults with an acute anterior cruciate ligament (ACL) tear, the mid-term (five year) patient reported and radiographic outcomes between those treated with rehabilitation plus early ACL reconstruction and those treated with rehabilitation and optional delayed ACL reconstruction. Design Extended follow-up of prospective randomised controlled trial. Setting Ortho

Prevention strategies are critical to reduce infection rates in total joint arthroplasty (TJA), but evidence-based consensus guidelines on prevention of surgical site infection (SSI) remain heterogeneous and do not necessarily represent this particular patient population.

BACKGROUND: The aim of this study was to investigate the association between factors in metabolic syndrome (MetS; single and combined) and the risk of pancreatic cancer. METHODS: The Metabolic Syndrome and Cancer Project is a pooled cohort containing data on body mass index, blood pressure, and blood levels of glucose, cholesterol, and triglycerides. During follow-up, 862 individuals were diagnose

OBJECTIVES: the purpose of this study was to assess the predictive accuracy of conventional cardiovascular risk factors for incident heart failure and atrial fibrillation, and the added benefit of multiple biomarkers reflecting diverse pathophysiological pathways. BACKGROUND: heart failure and atrial fibrillation are interrelated cardiac diseases associated with substantial morbidity and mortality

In the present thesis, analytical sample pre-treatment methods for the determination of trace metal ions in complex matrices were developed and tested. These methods were based on membrane fractionation, clean-up and enrichment of analytes and applied to the determination of aluminium, cadmium, cobalt, chromium, copper, nickel and lead in biological and environmental samples. In one application d

I dag arbetar cirka 22 procent av de arbetande kvinnorna i Sverige i vård och omsorgssektorn. Vård och omsorg är en kvinnodominerad sektor som karaktäriseras av höga sjuktal, hög personalomsättning och rekryteringsproblem. Sveriges befolkning blir allt äldre samtidigt som vården av svårt sjuka patienter i allt högre grad flyttas ut från sjukhusen till hemmet. Detta utgör stora utmaningar för hemtj

Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with as

Purpose of Review: This review sought to describe quality improvement initiatives in fragility fracture care and prevention. Recent Findings: A major care gap persists throughout the world in the secondary prevention of fragility fractures. Systematic reviews have confirmed that the Fracture Liaison Service (FLS) model of care is associated with significant improvements in rates of bone mineral de

Objective: To facilitate a greater likelihood of favorable response to new disease-modifying therapies, recruitment of patients at an earlier stage of their disease into clinical trials may be an attractive strategy. Hence, there is a need to develop widely accepted classification criteria for early-stage knee osteoarthritis (OA). We have proposed a set of classification criteria for early-stage k