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Neuronal protein synthesis is severely depressed following stress such as heat-shock, hypoxia, and hypoglycemia. Following reversible cerebral ischemia, protein synthesis is transiently inhibited in ischemia-resistant areas, but persistently depressed in vulnerable brain regions. Eukaryotic initiation factor 2 (elF-2) activity, that is, the formation of the ternary complex elF-2 · GTP · initiator

Abstract: The changes in the levels of protein kinase C [PKC(α, βII, γ)] were studied in cytosolic and particulate fractions of striatal homogenates from rats subjected to 15 min of cerebral ischemia induced by bilateral occlusion of the common carotid arteries and following 1 h, 6 h, and 48 h of reperfusion. During ischemia the levels of PKC(βII) and ‐(γ) increased in the particulate fraction to

Extracellular concentrations of the brain metabolite quinolinic acid, an endogenous excitotoxin, were monitored by microdialysis in rat neostriatum and hippocampus/cortex during and following a 30-min period of insulin-induced hypoglycaemia. During hypoglycaemia-induced isoelectricity, extracellular levels of quinolinic acid in the striatum (basal value, 1.1 ± 0.3 pmol per 30-μl fraction) were ele

A detailed light- and electron-microscopic study of the damage to the rat dentate gyrus in hypoglycemia was undertaken, in view of the previously advanced hypothesis that hypoglycemic nerve cell injury is mediated by a released neurotoxin. The distribution of neuronal necrosis showed a relationship to the subarachnoid cisterns. Electron microscopy of the dentate granule cells and their apical dend

Vertebrates capable of powered flight rely on wings, muscles that drive their flapping and sensory inputs to the brain allowing for control of the motor output. In birds, the wings are formed of arrangements of adjacent flight feathers (remiges), whereas the wings of bats consist of double-layered skin membrane stretched out between the forelimb skeleton, body and legs. Bird feathers become worn f

Epidemiologists have for many decades reported on the patterns and distributions of diabetes within and between populations and have helped to elucidate the aetiology of the disease. This has helped raise awareness of the tremendous burden the disease places on individuals and societies; it has also identified key risk factors that have become the focus of diabetes prevention trials and helped sha

Synucleinopathies, characterized by intracellular aggregation of α-synuclein protein, share a number of features in pathology and disease progression. However, the vulnerable cell population differs significantly between the disorders, despite being caused by the same protein. While the vulnerability of dopamine cells in the substantia nigra to α-synuclein over-expression, and its link to Parkinso

Popular Abstract in Swedish Fordons körmönster, dvs deras hastighets- och accelerationsprofiler, påverkar avgasutsläpp och bränsleförbrukning avsevärt. Detta projekt syftade till att undersöka körmönster i tätort genom att behandla följande delområden: 1) Hur kan körmönster mätas?, 2) Hur kan körmönster beskrivas? – dvs att finna mått för att karakterisera olika egenskaper hos körmönster., 3) Vad Driving patterns, i.e. the speed and acceleration profiles of vehicles affect exhaust emission and fuel consumption considerably. This project was aimed at investigating urban driving patterns by focusing on the following issues: 1) how to measure driving patterns, 2) measures for the description of driving patterns, 3) identification of characteristics of driving patterns that have significant ef

Popular Abstract in Swedish Syfte Syftet med denna avhandling var att undersöka om barn födda i Sverige till invandrare (icke-Svenskar) hade en ökad risk för typ 1 diabetes (T1D) och om immunogenetiska markörer för T1D (HLA och icke-HLA genetiska faktorer samt ö-cellsantikroppar) skiljde sig från svenska T1D barn (Svenskar). Målsättningen var också att analysera ärftliga förutsättningar (T1D och TThis thesis examined whether the offspring of immigrants (non-Swedes) to Sweden are at increased risk of Type 1 Diabetes (T1D) when they are born or live in Sweden. It also evaluated if their T1D and T2D-related genes differed from Swedish patients and whether this genetic heritage determined the types and existence of islet autoantibodies at time of diagnosis and affected the classification of di

The following study explores the economical and political determinants influencing the Swedish parliamentary election outcomes, through the lens of statistical modeling. With analysis of election data from 1970-2022, we employed both multiple regression and ridge regression to explore the following key variables: immigration, taxation, unemployment, inflation, poll performance, incumbency, margina

Titel: Flytande aktier, svävande siffror: spelar free float roll? Seminariedatum: 2024-05-30 Kurs: Examensarbete i finansiering (FEKH89), 15 högskolepoäng. Författare: Jeanne Lindestam, Julia Rodén, Anna Wogén Handledare: Maria Gårdängen Nyckelord: Accruals earnings management, free float, den modifierade Jones-modellen, börspsykologi, agentteori, signalteori, earnings smoothing, earnings ag

This paper presents the results of an interdisciplinary study encompassing data collected from 108 in-depth interviews and 15 participatory workshops aimed at exploring the requirements of a diverse range of stakeholders in relation to assistive augmentative technologies. The study involved 39 poststroke patients with hand paresis, 39 individuals with spinal cord injuries affecting upper limb funcThis paper presents the results of an interdisciplinary study encompassing data collected from 108 in-depth interviews and 15 participatory workshops aimed at exploring the requirements of a diverse range of stakeholders in relation to assistive augmentative technologies. The study involved 39 poststroke patients with hand paresis, 39 individuals with spinal cord injuries affecting upper limb func

IntroductionYoung migrants are increasingly recognised as being particularly vulnerable to sexual violence. This vulnerability is largely structural, due to the different laws and policies impacting their access to rights and services. Post-structural approaches to policy argue that policies are not responses to existing problems, but rather that social issues are constructed through policy. They

The thesis explores the criminal liability of drivers when accidents are caused by automated driving systems in cars. It examines the question of how the liability in cases concerning automated driving systems should be solved using current applicable Swedish law and how this question may be handled in the future based on research published about automated driving systems. The thesis begins with a

While advances in biologging have revealed many spectacular animal migrations, it remains poorly understood how young animals learn to migrate. Even in social species, it is unclear how migratory skills are transmitted from one generation to another and what implications this may have. Here we show that in Caspian terns Hydroprogne caspia family groups, genetic and foster male parents carry the ma

Regionaliseringsprosesser og politisk regionalisme har over lengre tid blitt sentrale temaer i akademiske debatter om nasjonalstaters re-skalering og den såkalte misnøyens geografi. Lignende dynamikker er også til stede i Norge, hvor regionreformen som ble gjennomført i 2020 møtte motstand langs sentrum-periferi-linjer. Slike fenomener stiller spørsmål om hvordan ulike aktører bidrar til regionersRegionalisation processes and regionalist contestation have been the subjects of long-standing debates on state rescaling and political geographies of discontent. Similar dynamics are also present in Norway, where a recent regional reform has faced opposition along centre-periphery lines. These phenomena raise questions about how different actors discursively enact the institutionalisation and/or