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This paper establishes the model basis regarding the ultimate limit state consisting of structural, loading, and probabilistic models of the support structure of offshore wind energy converters together with a sensitivity study. The model basis is part of a risk based assessment and monitoring framework and will be applied for establishing the "as designed and constructed" reliability as prior inf
In this paper we make three points about the current state and promising future directions of qualitative research in our field of innovation policy research. First, we argue that research design and methods are dealt with quite superficially in most innovation policy studies papers and journals providing little guidance to new scholars as to how to approach their research. Secondly we argue that
OBJECTIVES: Clinical presentation of primary Sjögren's syndrome (pSS) varies considerably. A shortage of evidence-based objective markers hinders efficient drug development and most clinical trials have failed to reach primary endpoints.METHODS: We performed a multicentre study to identify patient subgroups based on clinical, immunological and genetic features. Targeted DNA sequencing of 1853 auto
This paper presents an integrated simulation-based methodology for considering the effects of weather on formwork removal times. An expert tool for estimating formwork removal times and weather data with high resolution are integrated into a discrete-event simulation model containing a process model of in-situ concrete wall operations. In addition, operational measures (denoted as curing strategie
Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liqui
Background and purpose: Substantial inter-observer variations in target delineation have been presented previously. Target delineation for paediatric cases is difficult due to the small number of children, the variation in paediatric targets, the number of study protocols, and the individual patient's specific needs and demands. Uncertainties in target delineation might lead to under-dosage or ove
Background: Isocapnic hyperventilation (IHV) is a method that shortens time to extubation after inhalation anaesthesia using hyperventilation (HV) without lowering airway CO 2 . In a clinical trial on patients undergoing long-duration sevoflurane anaesthesia for major ear–nose–throat (ENT) surgery, we evaluated th
The central challenge tackled in this thesis is the development of an optical imaging approach capable of multidimensional image capture of dynamic samples. Many conventional optical imaging approaches, which can obtain dimensional information such as spectral, polarisation, or volumetric, to name a few, about samples either employ sequential image capture or parallelised detector arrangements. Du
In the latest World Tourism Barometer, UNWTO (2020) predicts that global tourism could decline by up to 80% this year. While many tourism-dependent economies in Europe are currently suffering from under-tourism, the heated debate between tourism developers and local stakeholders about adverse impacts of over-tourism is likely to reignite even stronger once the inrush of tourists returns. As a resu
In this work we report the impact of using mid-infrared laser-induced thermal grating spectroscopy (IRLITGS) for temperature measurements in flames by probing hot water lines. The measurements have been performed in the product zone of laminar atmospheric CH 4 /H 2 /air flat flames with equivalence ratio ranging between 0.6 and 1.05. LITGS is a technique based on thermalization through collisions
Carbonic anhydrase (CA) is a thoroughly studied enzyme. Its primary role is the rapid interconversion of carbon dioxide and bicarbonate in the cells, where carbon dioxide is produced, and in the lungs, where it is released from the blood. At the same time, it regulates pH homeostasis. The inhibitory function of sulfonamides on CA was discovered some 80 years ago. There are numerous physiological-t
Time-resolved optical pump/X-ray probe experiments are often used to study structural dynamics. To ensure high temporal resolution, it is necessary to monitor the timing between the X-ray pulses and the laser pulses. The transition from a crystalline solid material to a disordered state in a non-thermal melting process can be used as a reliable timing monitor. We have performed a study of the non-
Imaging the spray formation region of atomizing sprays is particularly challenging due to the presence of a variety of irregular liquid structures such as ligaments, liquid blobs, droplets, liquid sheets and a possible liquid core. The number and concentration of those liquid bodies dictate the presence of liquid/air interfaces, which are responsible to undesired scattering effects. The resulting
A new model of color reconnection in the Monte Carlo generator Herwig 7 is presented. It is based on the minimization of a boost-invariant distance of the parton system, where all partons have momentum as well as spacetime position assigned. We test the influence of both types of variables, namely the rapidity span and transverse distance, on the actual need to reconnect the system to better descr
Studien fokuserar på sociala- och organisatoriska aspekter av den digitala arbetsmiljön och hargenomförts av en pedagog och en datavetare i samverkan. Införandet av Canvas som lärplattform haranvänts för att studera implementeringen av ett nytt system som en del av lärares arbetsmiljö.Med material från intervjuer och observationer ges en beskrivning av hur universitetslärararbetetunderlättats och
Spinocerebellar ataxia type 3 (SCA3), caused by a CAG repeat expansion in the ataxin-3 gene (ATXN3), is characterized by neuronal polyglutamine (polyQ) ATXN3 protein aggregates. Although there is no cure for SCA3, gene-silencing approaches to reduce toxic polyQ ATXN3 showed promise in preclinical models. However, a major limitation in translating putative treatments for this rare disease to the cl
