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Popular Abstract in Swedish Den kemiskt enkla föreningen cis-[PtCl2(NH3)2)] (cisplatin) används för behandling av vissa cancerformer. Föreningen är i allmänhet giftig för kroppens organ och kroppen utvecklar resistens, vilket begränsar den kliniska effektiviteten. Generellt anses det att den önskade anticancer-effekten fås som ett resultat av inbindningen av platinakomplexen till DNA, medan interaIn this thesis reductions of model and anticancer active Pt(IV) complexes with thiols and ascorbic acid and substitution reactions of cisplatin and model Pt(II) complexes with S-donor nucleophiles (rescue agents) have been investigated using stopped-flow and UV/VIS spectrophotometry. Glutathione (GSH) reduction of the anticancer active Pt(IV) compounds t- and c-[PtCl4(cha)(NH3)] (cha = cyclohexyla

Popular Abstract in SwedishDjurgravpoesi är en form av tillfällespoesi och en subgenre till den vanliga begravningspoesin, som skrevs över människor. Den som skapade förutsättningarna för att denna diktart skulle få fäste i Sverige var änkedrottning Hedvig Eleonoras hovpoet Erik Lindschöld; hans gravdikter över änkedrottningens tikar är sannolikt skrivna på 1670-talet. Här börjar en linje som går This dissertation examines a hitherto neglected genre in Swedish poetry of the 17th and 18th centuries: the animal epitaph. From 1670 to 1760 a considerable number of such poems were composed by several of the leading poets of the day. In this dissertation, besides tracing the history of the genre back to its origins in the ancient Greek epigram, I am chiefly concerned with the functions that the

There are little data on the putative association between factors in the metabolic syndrome (MetS) and risk of bladder cancer. In the Metabolic Syndrome and Cancer project (Me-Can), measurements of height, weight, blood pressure and circulating levels of glucose, cholesterol, and triglycerides had been collected from 578,700 subjects in cohorts in Norway, Austria, and Sweden. We used Cox proportio

Retinal implant devices are becoming an increasingly realizable way to improve the vision of patients blinded by photoreceptor degeneration. As an electrode material that can improve restored visual acuity, carbon nanotubes (CNTs) excel due to their nanoscale topography, flexibility, surface chemistry, and double-layer capacitance. If vertically aligned carbon nanotubes (VACNTs) are biocompatible

The Cu-poor phases Cu(In,Ga)3Se5 and Cu(In,Ga)5Se8 play an important role both for understanding the Cu-(In,Ga)-Se material system and for growing high-efficiency Cu(In,Ga)Se2 thin film solar cells. Using extended X-ray absorption fine structure spectroscopy, we have studied the element-specific short-range structure of Cu(In,Ga)Se2, Cu(In,Ga)3Se5, and Cu(In,Ga)5Se8 alloys spanning the entire comp

Electric coupling between subcells of a monolithically grown multijunction solar cell in short circuit allows their simultaneous and independent characterization by means of photo- and electro-reflectance. The photovoltage generated by selective absorption of the pump beam in a given subcell during photoreflectance measurements results in reverse biasing the complementary subunits at the modulatio

This study scrutinizes gender differences in adolescent problem behaviour and its potential determinants, simultaneously taking into account the individual and contextual level, including personality, family and country characteristics. Using the 2010 EU Kids Online Survey, we estimate multilevel models on 18,027 individuals from 24 European countries. In line with earlier research, we find that b

METHODS: Patients with asthma and/or COPD who switched to BF Spiromax were matched (1:3) with non-switchers. Data were obtained from the Optimum Patient Care Research Database and Clinical Practice Research Datalink in the UK. The primary end point was the proportion of patients achieving disease control (using the risk domain control (RDC) algorithm); secondary end points were: exacerbation rate,

Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes

Background and objectives: Despite global warming, the climate in Northern Europe is generally cold, and the large number of deaths due to non-optimal temperatures is likely due to cold temperatures. The aim of the current study is to investigate the association between cold temperatures and all-cause mortality, as well as cause-specific mortality, in Tallinn and Riga in North-Eastern Europe. Mate

BACKGROUND: There is growing evidence for a negative impact of traffic-related air pollution on risk of dementia. However, the contribution of noise exposure to this association has been rarely examined.OBJECTIVE: We aimed to investigate the individual and combined effect of noise and air pollution on risk of dementia.METHODS: Data on dementia incidence over a 15 year period was obtained from the

OBJECTIVES: There is highly suggestive evidence for an effect of air pollution exposure on dementia-related outcomes, but evidence is not yet present to clearly pinpoint which pollutants are the probable causal agents. The aims of this study was to assess the longitudinal association between exposures of fine ambient particulate matter (PM2.5) from residential wood burning, and vehicle exhaust, wi

While the ability to measure low temperatures accurately in quantum systems is important in a wide range of experiments, the possibilities and the fundamental limits of quantum thermometry are not yet fully understood theoretically. Here we develop a general approach to low-temperature quantum thermometry, taking into account restrictions arising not only from the sample but also from the measurem

Background and purpose — The incidence of manipulation under anesthesia (MUA) after knee arthroplasty surgery has been reported to vary between 0.5% and 10%. We evaluated the incidence of MUA after primary knee arthroplasty in Sweden, the demographics of the patients and the risk of revision. Patients and methods — Between 2009 and 2013, 64,840 primary total and unicompartmental knee arthroplastie

BACKGROUND: The primary objective was to investigate the clinical and radiological outcome in patients undergoing major hip surgery using a novel antibiotic containing bone substitute for local augmentation in trochanteric fracture fixation or revision of total hip arthroplasty (THA).METHODS: We implanted a novel biphasic bone substitute CERAMENT™|G consisting of hydroxyapatite, calcium sulphate a

PURPOSE OF REVIEW: In the past decades, cysteinyl leukotrienes (CysLTs) and prostaglandin D2 have been recognized as key mediators of asthma and comorbid conditions for their potent broncho-active and proinflammatory properties. However, both the development and initial positioning of small molecules targeting these lipid mediators [i.e., leukotriene-synthesis inhibitors, CysLT-antagonists, and ch

Objectives: To analyze whether there is an association between neighbourhood deprivation and morbidity and mortality of lung cancer, beyond individual level characteristics. Design: The entire Swedish population aged over 50, a total of 3.2 million individuals, was followed from January 1, 2000, until admission due to morbidity or mortality of lung cancer during the study period, or the end of the