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Protein quantification using different LC-MS techniques is becoming a standard practice. However, with a multitude of experimental setups to choose from, as well as a wide array of software solutions for subsequent data processing, it is non-trivial to select the most appropriate workflow for a given biological question. In this review, we highlight different issues that need to be addressed by so
Artificial neural network (ANN) ensembles have long suffered from a lack of interpretability. This has severely limited the practical usability of ANNs in settings where an erroneous decision can be disastrous. Several attempts have been made to alleviate this problem. Many of them are based on decomposing the decision boundary of the ANN into a set of rules. We explore and compare a set of new me
Many bird species migrate long distances without any food intake and must optimize storage of energy with respect to minimization of aerodynamic drag. To contribute to the understanding of this issue, we investigated, by magnetic resonance imaging (MRI), spatial distributions of body fat during the accumulation process before migration. We collected data from 12 Lesser Whitethroats (Sylvia curruca
Fuel ethanol production from lignocellulosic materials is at a level where commercial biofuel production is becoming a reality. The solubilization of the hemicellulose fraction in lignocellulosic-based feedstocks results in a large variety of sugar mixtures including xylose. However, allowing xylose fermentation in yeast that normally is used for fuel ethanol production requires genetic engineerin
In this study linear free energy relationships (LFER) are applied to the relaxation of core-excited states in aliphatic CH3X compounds. There are at least two valence orbitals involved in Auger decay following C-CH3 1s -> sigma*(C-X) excitation, which may as well be localized on the substituents in this series. Therefore, the observed property cannot be strictly attached to the so-called reaction
Kidney disease is a growing problem in the whole world. It is important to find these patients in an early state of the disease because then they can be treated and dialysis treatment can be avoided. To measure the glomerular filtration rate (GFR) an invasive technigue is used. In this thesis an equation to estimate GFR (eGFR) by drawing a blood sample and measure the concentration of cystatin C i
The current study evaluated amyloid-beta oligomers (A beta o) in cerebrospinal fluid as a clinical biomarker for Alzheimer's disease (AD). We developed a highly sensitive A beta o ELISA using the same N-terminal monoclonal antibody (82E1) for capture and detection. CSF samples from patients with AD, mild cognitive impairment (MCI), and healthy controls were examined. The assay was specific for oli
The design of multiple antennas in compact mobile terminals is a significant challenge, due to both practical and fundamental design tradeoffs. In this paper, fundamental antenna design tradeoffs of multiple antenna terminals are presented in the framework of characteristic mode analysis. In particular, interactions between the antenna elements and the characteristic modes and their impact on desi
To make transportation safer, more efficient, and less harmful to the environment, traffic telematics services are currently being intensely investigated and developed. Such services require dependable wireless vehicle-to-infrastructure and vehicle-to-vehicle communications providing robust connectivity at moderate data rates. The development of such dependable vehicular communication systems and
Background: Neutralizing antibodies provide markers for vaccine-induced protective immunity in many viral infections. By analogy, HIV-1 neutralizing antibodies induced by immunization may well predict vaccine effectiveness. Assessment of neutralizing antibodies is therefore of primary importance, but is hampered by the fact that we do not know which assay(s) can provide measures of protective immu
In this paper we discuss new adaptive proposal strategies for sequential Monte Carlo algorithms—also known as particle filters—relying on criteria evaluating the quality of the proposed particles. The choice of the proposal distribution is a major concern and can dramatically influence the quality of the estimates. Thus, we show how the long-used coefficient of variation (suggested by Kong et al.
Abstract in UndeterminedThis paper addresses the failure of activation programmes to achieve a rapid return to work when they are directed towards the long-term ill. The empirical basis for the paper is an analysis of the outcomes for 691 individuals in Sweden chosen for a re-activation policy programme to shorten their sick leave and increase their chances of returning to work. The outcome at the
A high-spin rotational band was observed in the N=90 nucleus Yb-160 with moment of inertia and decay characteristics very similar to recently discovered sequences in Er-157,Er-158. These latter structures were discussed in terms of strongly deformed triaxial bands. Detailed cranked Nilsson-Strutinsky calculations were performed that predict that well-deformed triaxial structures are also expected
This paper analyses recent experiences at the School of Social Work, Lund University, the first in Sweden to use an innovative pedagogical approach for integrating social service users with social work students in the classroom (an EU-funded project). The concept of gift exchange was used to make sense of the approach. Gift exchange is based on the norm of reciprocity and the principles of gift ec
The main purpose of this research is to provide an agenda for future warehousing research relevant for both academic development and practitioners’ needs. In order to suggest a practically relevant future research agenda, first a comprehensive literature review was performed to identify research areas covered in the literature. Then, 15 warehouse managers and senior consultants were interviewed to
The purpose of this thesis was to determine whether perimetry using a new model to interpret deterioration or improvement in the visual field can be employed to assess change in visual function over time in diabetes. Diabetic retinopathy has long been considered a microvascular disease, but it is still a matter of debate to what extent diabetes also affects retinal neurons. Visual acuity is routi
One of the greatest challenges for the transport sector today is reducing its environmental impact. This applies especially to the emission aspects, much due to increasingly stringent emissions legislations. Carbon dioxide (CO2) is considered an important greenhouse gas, but also unburned hydrocarbons (HC), nitric oxides (NOx) and soot pose environmental as well as health risks. Compared to diesel
