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Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case–control pairs from 20 prospective cohorts included in the inte

Background: Areal bone mineral density (aBMD) estimated by dual-energy X-ray absorptiometry (DXA) is used to estimate peak bone mass, define osteoporosis and predict fracture. However, as aBMD is calculated as bone mineral content (BMC) divided by the scanned area, aBMD displays an inverse relationship with bone size. In a skeleton that is increasing in size, this is a problem, as bone size is an

Aims: We aimed to discover and replicate associations between leisure-time physical activity and cardiovascular candidate plasma protein biomarkers and to examine whether the associations were independent of body fat. Methods: We used cross-sectional data from two population-based cohorts, the EpiHealth (discovery cohort; n = 2239) and the Swedish Mammography Cohort – Clinical (SMCC; replication c

Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV1: r

This study presents a state-of-the-art overview on the application of ultrasound technology in the drying of food products, including the ultrasound pre-treatment and ultrasound assisted drying. The effect of main parameters and ultrasound technology on the drying kinetics and food quality were discussed. Inconsistencies were pointed out and analyzed in detail. Results showed that for ultrasound p

Augmentation of heat transfer must always be judged against an additional pressure loss. To this context, this paper explores slitted ribs on the turbulent flow and heat transfer characteristics in rectangular cooling channels with an aspect ratio of 4:1. A verified v2f turbulence model is applied in the present numerical simulations in the Reynolds number range from 20,000 to 80,000. The flow and

Introduction: Oral contraceptives (OC) have been shown to give a transient increased breast cancer risk. However, studies on breast cancer survival after OC use are sparse and conflicting.Aim: The aim of this study was to examine previous use of OC in relation to survival after breast cancer diagnosis.Methods: Data was collected from Malmö Diet and Cancer Study, with baseline examinations between

BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. METHODS: In thi

To advance microfluidic integration, we present the use of two-photon additive manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with nanometer precision. We demonstrate this technique by tailoring microfluidic nozzles and mixers for time-resolved structural biology at X-ray free-electron lasers (XFELs). We achieve submicron jets with speeds exceeding 160 m s−1, w

The twisted elliptical tube heat exchangers with the novel coupling-vortex chessboard tube layout (TETHXs-CV) were simulated with the RNG k-ε model in software Fluent 15.0. The shell-side flow pattern at the tangential points between adjacent tubes in traditional TETHX is countercurrent while that in TETHX-CV is concurrent, which helps enhance heat transfer capability without any extra manufacturi

We enrolled 427 human immunodeficiency virus-infected children (median age, 7.3 years), 59.2% severely immunodeficient, with suspected tuberculosis in Southeast Asian and African settings. Nontuberculous mycobacteria were isolated in 46 children (10.8%); 45.7% of isolates were Mycobacterium avium complex. Southeast Asian origin, age 5-9 years, and severe immunodeficiency were independently associa

Background: Cohort studies often use simple models, for example, completers-only or aggregated scores, to assess changes in imaging outcomes. With more data available, this introduces selection bias. Integrated analyses allow scores from multiple reading rounds; therefore, we assessed their effect on the change estimates’ precision compared with the completers-only analysis. Second, we compared ch

Economic sanctions are defined as the exercise of pressure by one state to produce a change in the political behaviour of another state. Traditional economic sanctions are directed at the entire population of a state whilst targeted sanctions are directed at a state’s individuals. This thesis discusses the application of economic sanctions against Iran by the UN, the EU and the United States. Econ

Införande av en klimatskatt på nötkött i Sveriges påverkan på förekomsten av kolorektalcancer Man har i flertalet studier påvisat att konsumtion av rött kött och processat kött (däribland nötkött) skulle kunna ha en negativ inverkan på människors hälsa. Framförallt visar studier på kopplingar mellan konsumtion av rött och processat och en ökad risk för kolorektalcancer. Vidare visar studier att pConsumption of red and processed meat has been found to effect human health and especially the occurrence of colorectal cancer. At the same time cattle farming and production of beef have been shown to severely effect the environment and particularly the climate. Taxation of beef could be an instrument to decrease the greenhouse gas emissions from the production of beef, but due to high transition

Uppsatsen fokuserar på privat skadeståndstalan vid konkurrensrättsliga överträdelser och på det nya direktivet 2014/104/EU, om vissa regler som styr skadeståndstalan enligt nationell rätt avseende överträdelser av medlemsstaternas och Europeiska unionens konkurrensrättsliga bestämmelser. Enligt unionsrätten har alla enskilda aktörer rätt till ersättning för skada som uppkommit till följd av en öveThe main focus of this thesis are private actions for damages due to infringements of the antitrust rules and the new directive 2014/104/EU, on certain rules governing actions for damages under national law for infringements of the competition law provisions of the Member States and of the European Union. According to European union law, all private actors are entitled to compensation for damages

Inom läkemedelssektorn, originalföretagen som investerar stora summor pengar i forskning och utveckling av nya läkemedel vanligtvis söker patent för flera skyddsområden. De försöker utnyttja det monopol ett patent ger för att skydda sina egna originalläkemedel mot generiska läkemedels marknadsinträde och utebliven vinst som det för med sig. Generiska företag för att kunna lansera sina generiska prIn the pharmaceutical sector, originator companies that invest large sum of money in R&D of new medicines usually file patent applications for several areas of protection. They try to take advantage of a monopoly that a patent grants to protect their medicines against generic entry on the market and consequently the loss of profits. Generic companies in order to be able to launch their generic

This thesis examines and compares spontaneous metaphor usage in conversations within and between generations. It investigates to what extent they can be seen as motivated by bodily, conventional and situated factors with the help of the Motivation and Sedimentation Model (MSM), which operates with these three levels of meaning. The model combines and integrates earlier accounts of metaphor motivat