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Influence of acidosis on lipid peroxidation in brain tissues in vitro

To study the influence of acidosis on free radical formation and lipid peroxidation in brain tissues, homogenates fortified with ferrous ions and, in some experiments, with ascorbic acid were equilibrated with 5–15% O2 at pH values of 7.0, 6.5, 6.0, and 5.0, with subsequent measurements of thiobarbituric acid-reactive (TBAR) material, as well as of water- and lipid-soluble antioxidants (glutathion

Cyclic AMP Concentrations in Rat Neocortex and Hippocampus During and Following Incomplete Ischemia : Effects of Central Noradrenergic Neurons, Prostaglandins, and Adenosine

Abstract: The concentrations of cyclic AMP, noradrenaline, glycogen, glucose, lactate, pyruvate, labile phosphate compounds, and free fatty acids were investigated in the rat neocortex and hippocampus during and following cerebral ischemia. An incomplete ischemia of 5 and 15 min duration was induced by bilateral carotid clamping combined with hypotension. The postischemic events were studied after

Cerebral metabolic and circulatory effects of 1,1,1-trichloroethane, a neurotoxic industrial solvent - 1. Effects on local cerebral glucose consumption and blood flow during acute exposure

The effects of inhaled 1,1,1-trichloroethane (3500, 6000, and 7800 ppm) on behavior, local cerebral blood flow, and local cerebral glucose consumption were studied in awake rats. The effect of the solvent inhalation on the EEG pattern and local cerebral blood flow was also studied in paralyzed animals under N2O analgesia. Exposure of awake animals to 6000 ppm 1,1,1-trichloroethane induced a decrea

Cortical spreading depression is associated with arachidonic acid accumulation and preservation of energy charge

The present study aimed to study the relation between the release of arachidonic acid (AA) and the energy state in cerebral cortices of rats during single episodes of cortical spreading depression (CSD). The changes in concentrations of AA, labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)], and glycolytic metabolites (lactate, pyruvate, glucose, and glycogen) were studied durin

The Long-Term Impact of Education on Mortality and Health: Evidence from Sweden

There is a well-documented large positive correlation between education and health and yet it remains unclear as to whether this is a causal relationship. Potential reasons for this lack of clarity include estimation using different methods, analysis of different populations and school reforms that are different in design. In this paper we assess whether the type of school reform, the instrument a

Animals of Ancient Kheny : The Rupestrian Collection

This paper presents an overview of animals depicted within the Swedish con-cession area of Gebel el-Silsila and Shatt el-Rigal, spanning the Prehistoric to the early Islamic period. It includes commentaries on stylistic, technical and chronological phases of the rock art, and present an overview of distribution patterns as well as a relative taxonomic morphology for the more frequent motifs. Main

Six Major Steps to Make Investigations of Suicide Valuable for Learning and Prevention

Objective: The decline in suicide rates has leveled off in many countries during the last decade, suggesting that new interventions are needed in the work with suicide prevention. Learnings from investigations of suicide should contribute to the development of these new interventions. However, reviews of investigations have indicated that few new lessons have been learned. To be an effective tool,

Flicker : a technological overview

Flicker can be annoying, but above all it can have a negative effect on human health; causing irritation, headaches, eye strain and migraines. With the introduction of LED lamps, flicker has once again become a problem. In addition to the unnecessary suffering caused to individuals, the negative consequences create an obstacle to the wide and rapid adoption of new LED technology and thus also an oFlicker can be annoying, but above all it can have a negative effect on human health; causing irritation, headaches, eye strain and migraines. With the introduction of LED lamps, flicker has once again become a problem. In addition to the unnecessary suffering caused to individuals, the negative consequences create an obstacle to the wide and rapid adoption of new LED technology and thus also an o

Last general practitioner consultation during the final month of life: a national medical record review of suicides in Sweden

ObjectivesIndividuals who die by suicide often consult their general practitioners (GPs) in their final weeks of life. The aim of this study was to gain a deeper knowledge of the clinical characteristics and GP assessments and treatments among individuals who consulted their GPs during the month preceding suicide. Further, we compared these features in those with and without contact with psychiatr

Anxiety symptoms preceding suicide: A Swedish nationwide record review

BackgroundThe literature on the relationship between anxiety and suicidal behaviors is limited and findings are mixed. This study sought to determine whether physicians noted anxiety symptoms and suicidality in their patients in the weeks and months before suicide.MethodsData were derived from a nationwide medical record review of confirmed suicides in Sweden in 2015. Individuals with at least one

The modified Medical Research Council scale misclassifies exertional breathlessness among people referred for exercise testing

BACKGROUND: Exertional breathlessness is a major symptom in cardiorespiratory disease and is often assessed using the modified Medical Research Council (mMRC) questionnaire. The mMRC might underestimate exertional breathlessness in people with impaired exercise capacity who have reduced their physical activity to avoid the symptom. We aimed to evaluate the ability of mMRC to detect abnormally high

Substance Use Problems and Death of Despair in a 32-Year Follow-Up Study of Suicide Attempters Examined at a Medical Emergency Inpatient Unit

Deaths of despair (DoD), encompassing suicide, drug overdose, and alcohol-related mortality, are often linked to social and psychological distress. This study examined the long-term risk of DoD among individuals previously hospitalized for suicide attempts, with a focus on substance use problems and psychiatric disorders as potential risk factors. A prospective cohort of 1044 individuals admitted

Effekter av ett kartläggningsbesök för individer med betydande hörselnedsättning

Syfte: Syftet med studien är att undersöka effekten av ett kartläggningsbesök med efterföljande telefonuppföljning på användande av kommunikationsstrategier och hörselrelaterad livskvalitet för individer med betydande hörselnedsättning (TMV4 60-69 dB HL på bättre örat). Metod: Ett kartläggningsbesök utformades där fokus låg på individen och dennes upplevda besvär kring den egna hörselnedsättningen

The Influence of Professionals on Prison Populations

Countries differ in the volumes of their prison population. This does not seem to simply be a result of differences in levels of crime, as prison populations does not appear to correspond with available indicators of crime, neither within nor between countries. Thus, other explanatory models should be available. Previously, the importance of economic, political, and cultural aspects has been studi

Inequality in fertility rate and modern contraceptive use among Ghanaian women from 1988-2008

Background: In most resource poor countries, particularly sub-Saharan Africa, modern contraceptive use and prevalence is unusually low and fertility is very high resulting in rapid population growth and high maternal mortality and morbidity. Current evidence shows slow progress in expanding the use of contraceptives by women of low socioeconomic status and insufficient financial commitment to fami

Hörselrehabilitering via Internet - en randomiserad kontrollerad studie

Syftet med HörNet var att undersöka om vi med hjälp av en strukturerad, individuell internetutbildning kunde minska hörselskadades handikappupplevelse. Vidare ville vi undersöka om internetutbildningen ledde till forbättrad hörapparatnytta, om deltagarna upplevde minskad oro och nedstämdhet samt om de var mer nöjda med sina hörapparater efter utbildningen. Utbildningen bestod av fem veckornoduler

Hälsoeffekter av stegtävling på ett företag.

De senaste 15-20 åren har övervikt och fetma blivit ett växande folkhälsoproblem i västvärlden. Befolkningen har en allt mer stillasittande fritid och en tredjedel uppfyller inte den föreslagna rekommendationen om 30 minuters fysisk aktivitet om dagen. Användning av stegräknare kan vara ett sätt att motivera och inspirera till ökad fysisk aktivitet. På ett stort processföretag med dag- och skift a