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Para athletes are at higher risk for sports-related injuries, illnesses and other health conditions when participating in sports. In fact, the unique demands placed on Para athletes, both in terms of the specific impairments they experience and the adaptive equipment they use, can lead to a distinctive set of challenges and risks in the context of sports-related health compared to nondisabled athl
Global health is a multidisciplinary field focused on improving health and achieving equity in health for all people worldwide. The COVID-19 pandemic left a profound and lasting impact on global mental health, triggering a surge in anxiety, depression, and stress-related disorders across all age groups and regions. As the world transitions into the post-COVID period, mental health has emerged as a
Background: Large bone defects are challenging to manage clinically and usually require treatment with bone graft or bone graft substitute. This study evaluated the effect of romosozumab, a sclerostin antibody, in combination with demineralized bone matrix (DBM) on bone regeneration in a critical-size ulnar defect model in nonhuman primates. Methods: In cynomolgus monkeys (N = 22, male, 10–12 year
Patients with dementia experience a steady deterioration in cognitive function that increases mortality and impairments. Moreover, dementia is also anticipated to increase significantly in prevalence as the world's population ages, placing a strain on healthcare systems throughout the globe. Hence, early identification and prediction of dementia are essential due to timely treatments, enhanced pat
Asthma is a common, multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes and endotypes and the availability of targeted biologic treatment options, the disease remains uncontrolled in a substantial proportion of patients with risk of exacerbations, requiring systemic corticosteroids, and with progre
Persistent Pain (PP) in children often has a high impact on their functioning. Knowledge about how to meet the needs is insufficient, especially regarding younger children, children with comorbid psychiatric health conditions, and within different national contexts. A specialized pediatric pain clinic for PP in Sweden offers assessment and interdisciplinary pain rehabilitation (IPR) and collects d
Background and objective Breathlessness is associated with higher rates of unplanned health service utilisation. We aimed to evaluate any associations between the severity of breathlessness limiting exertion (hereafter breathlessness), time between breathlessness recording and subsequent unplanned hospital admissions, and length of stay. Methods A retrospective cohort study of adults seen in gener
Upper-limb complications (ULCs) in diabetes, affecting joints, tendons, muscles, con-nective tissue, nerves, and skin, are underrecognized but prevalent conditions in type 1 and type 2 diabetes. Advances in diabetes care have extended life expectancy, leading to an aging population with diabetes with increased susceptibility to long-term complications beyond traditional vascular issues. Despite so
Summary: The relationship between rheumatoid arthritis (RA) and fracture risk was estimated in an international meta-analysis of individual-level data from 29 prospective cohorts. RA was associated with an increased fracture risk in men and women, and these data will be used to update FRAX®. Introduction: RA is a well-documented risk factor for subsequent fracture that is incorporated into the FRA
Neuromuscular disorders (NMDs) are disorders of the motor unit (motor neuron diseases, diseases of the peripheral nerves, neuromuscular junction diseases, and diseases affecting the muscle fibers). A common denominator of these diseases is muscle atrophy and progressive weakness. Quantitative assessments of muscle function are therefore essential to follow disease progression, to understand the as
Background: Pain in childhood is common, but there is an information gap on initial care seeking. Our aim was to determine trends and variations in the consultation prevalence and incidence of musculoskeletal pain, and most common sites of pain, in children and young people presenting to UK primary care. Methods: A national UK primary care database (CPRD Aurum) was used to determine annual prevale
Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA) is a multilevel regression approach grounded in intersectionality theory. It examines inequalities across intersections of social identities (e.g., gender, ethnicity, class) and is argued to provide more accurate predictions of intersectional means than conventional methods that estimate group means directly or vi
Introduction The recognition of breathlessness in clinical practice appears suboptimal, despite its prevalence and impact. This study aimed to explore the content of clinical conversations about breathlessness and patients’ level of self-reported openness when discussing their breathlessness. Methods A cross-sectional, online survey of Australian adults (≥18 years) stratified to the 2016 National
INTRODUCTION: Future physicians must develop the necessary knowledge and skills to effectively manage challenging patient communication. To design linked meaningful learning activities, perspectives from students and teachers need to be taken into account as well as students' previous knowledge. Aiming to better understand how this knowledge can be acquired through patient simulation, we examined
The building permit is usually the final decision of urban governance for public authorities, whereby the private actor is given the right to construct at the urban plot. But in urban areas there is an urban context, which calls the attention to the need of a planning perspective of the assembled built environment. Detailed plans are required, and they ought to be considered in a total urban or mu
