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Longitudinal Changes in Kidney Function Estimated from Cystatin C and Its Association with Mortality in Elderly Women

Background/Aims: Prospective data on age-related changes in kidney function are required, especially since the current Kidney Disease Improving Global Outcomes (KDIGO) definition has been suggested to classify a large number of elderly people with CKD. Objective: This study, a complement to our previous Cr-based study in the same cohort, is aimed at evaluating cystatin C (cysC)-based changes in ki

Development of a polygenic risk score to improve screening for fracture risk : A genetic risk prediction study

BACKGROUND: Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low genetic risk. We therefore tested whether a polygenic risk score for heel quantitative ultrasound speed of sound (SOS)-a heritable risk factor for osteopo

Time trends in pediatric fractures in a Swedish city from 1950 to 2016

Background and purpose — As previous studies indicate time trends in pediatric fracture incidence, we followed the incidence in a Swedish city between 1950 and 2016. Patients and methods — Malmö city, Sweden had 322,574 inhabitants in 2015. We used diagnosis registry, charts, and radiographs of the only city hospital to classify fractures in individuals < 16 years in 2014–2016, and compared these

A numerical study of heat transfer effects and aerodynamic noise reduction in superheated steam flow passing a temperature and pressure regulation valve

Steam is a common medium in thermal engineering. When it flows through a throttling element, the aerodynamic noise may occur due to the disturbance. In this investigation, superheated steam flowing through a Venturi tube, one of the main parts in a temperature and pressure regulation valve, at different thermal conditions is studied to analyze to effects of heat transfer on the acoustic power. Wit

The effect of maternal body mass index on duration of induced labor

Introduction: Obese primiparous women with induction of labor are at high risk for a cesarean section. There are contradictory results regarding time in induced labor in relation to maternal body mass index (BMI). It is important to characterize the course of induced labor to prevent unnecessary cesarean section. We aimed to evaluate whether the duration of labor was associated with maternal BMI i

Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis

Neutrophil extracellular traps (NETs) play a key role in the development of acute pancreatitis (AP). In the present study, we studied the role of extracellular cold-inducible RNA-binding protein (eCIRP), a novel damage-associated-molecular-pattern molecule, in severe AP. C57BL/6 mice underwent retrograde infusion of taurocholate into the pancreatic duct. C23, an eCIRP inhibitor, was given 1 h prio

Geographical and sociodemographic differences in discontinuation of medication for chronic obstructive pulmonary disease – a cross-classified multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA)

Background: While discontinuation of COPD maintenance medication is a known problem, the proportion of patients with discontinuation and its geographical and sociodemographic distribution are so far unknown in Sweden. Therefore, we analyse this question by applying an innovative approach called multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). Patients and Metho

Global health policy in the 21st century : Challenges and opportunities to arrest the global disability burden from musculoskeletal health conditions

The profound burden of disease associated with musculoskeletal health conditions is well established. Despite the unequivocal disability burden and personal and societal consequences, relative to other non-communicable diseases (NCDs), system-level responses for musculoskeletal conditions that are commensurate with their burden have been lacking nationally and globally. Health policy priorities an

Ultrafast hot-hole injection modifies hot-electron dynamics in Au/p-GaN heterostructures

A fundamental understanding of hot-carrier dynamics in photo-excited metal nanostructures is needed to unlock their potential for photodetection and photocatalysis. Despite numerous studies on the ultrafast dynamics of hot electrons, so far, the temporal evolution of hot holes in metal–semiconductor heterostructures remains unknown. Here, we report ultrafast (t < 200 fs) hot-hole injection from Au

Reducing energy loss via tuning energy levels of polymer acceptors for efficient all-polymer solar cells

The open-circuit voltage (Voc) of all-polymer solar cells (all-PSCs) is typically lower than 0.9 V even for the most efficient ones. Large energy loss is the main reason for limiting Voc and efficiency of all-PSCs. Herein, through materials design using electron deficient building blocks based on bithiophene imides, the lowest unoccupied molecular orbital (LUMO) energy levels of polymer acceptors

Manganese doped eco-friendly CuInSe2 colloidal quantum dots for boosting near-infrared photodetection performance

CuInSe2 (CISe) colloidal quantum dots (QDs) display promising applications in photodetection especially within near-infrared (NIR) regions due to their high extinction coefficient and environmental-friendly. However, the high trap density and poor crystal quality introduced by the ternary structure result in low photodetection of CISe QDs devices. Herein, we dope transition metal manganese ions (M

Thermodynamic and exergoeconomic analysis of a novel CO2 based combined cooling, heating and power system

In this paper, a novel combined cooling, heating and power (CCHP) system consisting of a supercritical carbon dioxide (sCO2) power cycle, a transcritical carbon dioxide (tCO2) power cycle with a carbon dioxide based refrigeration cycle, and a direct heating (DH) system is proposed. In the novel system, the waste heat from sCO2 power cycle is recovered by the tCO2 power cycle to generate additional

Operando time- and space-resolved high-energy X-ray diffraction measurement to understand hydrogen-microstructure interactions in duplex stainless steel

Local strain development in the microstructure of a commercial 25Cr-7Ni super duplex stainless steel was mapped using high-energy x-ray diffraction during cathodic hydrogen charging under constant uniaxial load. The infusion of hydrogen resulted in tensile strains in austenite grains, one order of magnitude larger than those in the ferrite. Most strain evolution occurred at the near-surface, with

Prediction of mass transfer coefficient of the continuous phase in a structured packed extraction column in the presence of SiO2 nanoparticles

In this experimental study, mass transfer and hydrodynamic parameters of water/kerosene/acetic acid system in a packed column were investigated, in which the mass transfer direction was set from the continuous phase (saturated water of kerosene and acetic acid) to the dispersed phase (saturated kerosene of water) in all the experiments. To assess the impact of nanoparticles on mass transfer, the e

Entropy Study on the Enhanced Heat Transfer Mechanism of the Coupling of Detached and Spiral Vortex Fields in Spirally Corrugated Tubes

The present work numerically studied the enhanced heat transfer mechanism of the coupled fields of detached and spiral vortices in symmetrical and asymmetrical spirally corrugated tubes. The heat transfer and viscous dissipation were analyzed by evaluating the entropy combined with the flow patterns, and the global entropy generation rate was analyzed by considering the local Nusselt number and fr

Low-Power Resistive Memory Integrated on III-V Vertical Nanowire MOSFETs on Silicon

III-V vertical nanowire MOSFETs (VNW-FETs) have the potential to extend Moore’s law owing to their excellent material properties. To integrate highly scaled memory cells coupled with high performance selectors at minimal memory cell area, it is attractive to integrate low-power resistive random access memory (RRAM) cells directly on to III-V VNW-FETs. In this work, we report the experimental demon

Ageing and glaucoma progression of the retinal nerve fibre layer using spectral-domain optical coherence tomography analysis

Purpose: To compare the effects of ageing and glaucoma progression on the thickness of the circumpapillary retinal nerve fibre layer (cpRNFL) and to evaluate the performance of a set of optical coherence tomography (OCT) progression analyses. Methods: The cpRNFL was measured twice by OCT at each of two visits made 10 years apart in 69 healthy individuals and 49 glaucoma patients. Both visits also

Mobility of near surface MOVPE grown InGaAs/InP quantum wells

In this work, we study the electron mobility of near surface metal organic vapor phase epitaxy-grown InGaAs quantum wells. We utilize Hall mobility measurements in conjunction with simulations to quantify the surface charge defect density. Buried quantum wells are limited by polar optical phonon scattering at room temperature. In contrast, the quantum wells directly at the surface are limited by r

Health impacts from ambient particle exposure in southern sweden

A health impact assessment (HIA) is an important tool for making informed decisions regarding the design and evaluation of environmental interventions. In this study, we performed a quantitative HIA for the population of Scania (1,247,993), the southernmost county in Sweden, in 2016. The impact of annual mean concentrations of particulate matter with an aerodynamic diameter <2.5 µm (PM2.5), modele