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Starting with the lead compound roquinimex, a selection of 3-quinolinecarboxamide derivatives were synthesized and evaluated for the treatment of the autoimmune disease multiple sclerosis. Structure-activity relationships were established in animal studies and from these, laquinimod was chosen as the drug candidate due to its superior potency and toxicological profile as compared to roquinimex. Ho
Additive manufacturing (AM) is revolutionizing industrial production by enabling the fabrication of complex, customized components with reduced material waste. However, the scheduling of AM machines presents significant challenges in terms of optimizing both time-related performance and energy consumption. This paper introduces a novel multi-objective mixed-integer linear programming (MILP) model
Objectives: Studies have reported promising results regarding artificial intelligence (AI) as a tool for improved mammographic screening interpretive performance. We analyzed AI malignancy risk scores from two versions of the same commercial AI model. Materials and methods: This retrospective cohort study used data from 117,709 screening examinations performed in BreastScreen Norway 2009–2018. The
Hand-eye calibration is a common problem in the field of collaborative robotics, involving the determination of the transformation matrix between the visual sensor and the robot flange to enable vision-based robotic tasks. However, this process typically requires multiple movements of the robot arm and an external calibration object, making it both time-consuming and inconvenient, especially in sc
DNA replication relies on precise coordination between proteins, including the sliding clamp proliferating cell nuclear antigen (PCNA), which encircles DNA to interact with key players in replication and repair. While biochemical studies have demonstrated interactions between PCNA and DNA polymerases δ and ε during DNA synthesis, the functional role of the Pol ε–PCNA interaction in vivo, particula
The testing and safety cases of assisted and automated driving (AAD) functions require considerations for nonideal environmental conditions, such as adverse and extreme weather. In these extreme conditions, perception sensors (e.g., camera, LiDAR, and RADAR), which build the situational awareness of the vehicle, might produce noisy and degraded data. Therefore, it is key to consider: 1) how to rel
With the increasing prevalence of microplastics (MPs) and nanoplastics (NPs) in global aquatic environments, their potential ecotoxicological and health impacts have become a major concern in environmental science. Slow sand filtration (SSF) is widely recognized for its low energy demand, ecological compatibility, and operational stability; however, its efficiency in removing small or neutrally bu
Maritime networks have been proposed as a mechanism for early agricultural and, by extension, language dispersals in several coastal and island regions. In Island Southeast Asia, such networks have sometimes been discussed as an alternative to the farming/language dispersal hypothesis. However, the relationships between Neolithic maritime networks and maritime economies are poorly known. Here, we
The article analyses selected parts of the permanent exhibitions at The National Sports Museum in Stockholm, Sweden, focusing on how environmental issues are presented. The analysis is deepened through theories about museology and the Anthropocene, the age of man, and the ways in which the museum addresses human responsibility and role in critical environmental issues. Through a critical discourse
Lättanvänd metod visar nyttan av behandling – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Lättanvänd metod visar nyttan av behandling 2010-07-01 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Både läkare och beslutsfattare be
https://www.vetenskaphalsa.se/lattanvand-metod-visar-nyttan-av-behandling/ - 2026-07-07
Erna Törnqvist: Sagor istället för narkos i magnetkameran – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Erna Törnqvist: Sagor istället för narkos i magnetkameran 2011-03-01 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Barn som genomg
https://www.vetenskaphalsa.se/sagor-istallet-for-narkos-i-magnetkameran-2/comment-page-1/ - 2026-07-07
Ärftliga faktorer vid barncancer kan vara underskattade – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Ärftliga faktorer vid barncancer kan vara underskattade 2012-03-29 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Foto: Colourbox Var
https://www.vetenskaphalsa.se/susanne-magnusson-arftliga-faktorer-vid-barncancer/ - 2026-07-07
Antibody response to Campylobacter jejuni/coli (CJC) was investigated, using an enzyme-linked immunosorbent assay, ELISA. With a mixture of lipopolysaccharide from two CJC strains as antigen in ELISA, all 24 tested rabbit anti-CJC sera showed high antibody levels. However, only 70% of sera from patients with Campylobacter enteritis demonstrated an antibody response against the combined LPS antigen
The clinical importance of asymptomatic proximal and distal deep vein thrombosis (DVT) remains uncertain and controversial. The aim of this retrospective, post-hoc analysis was to examine mortality and risk factors for development of proximal DVT in hospitalized patients with acute medical illness who were recruited into a randomized, prospective clinical trial of thromboprophylaxis with daltepari
Den övergripande målsättningen med projektet har varit att utifrån en prototyp av OE-staven ta fram ett fungerande mätsystem som håller jämförbar standard med dagens RF-mätningar. OE-metoden har visat sig uppfylla dessa krav och samtidigt vara ett kraftfullt verktyg för mätningar av RF-profiler i betongkonstruktioner. OE-metoden lämpar sig bäst att användas i svårbemästrade mätsituationer samt i s
A method for determining transition matrices for inhomogeneous dielectric shells is presented. The source can be either inside or outside the shell. The method is based upon expansions of the electric and magnetic fields in vector spherical harmonics. The expansion coefficients in the shell satisfy a system of linear ordinary differential equations in the radial direction. The expansion coefficien
The study was undertaken to prospectively evaluate a Streptococcus pneumoniae urinary antigen test for diagnosis of pneumococcal pneumonia among patient and control groups between 2004 and 2006. Microbiological analysis for these patients included Gram staining for sputum, sputum and blood culture. Nonconcentrated urine samples were tested using an immunochromatographic assay, the NOW S.pneumoniae
