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Monoclonal antibody therapies are effective for many but not all people with severe asthma. Precision medicine guides treatment selection using biomarkers to select patients most likely to respond according to their inflammatory endotypes. However, when assessing response to treatment, greater precision is required. We report a case series describing treatment response to mepolizumab in four sever

A variable gain transimpedance amplifier (TIA) is presented featuring single-ended to differential conversion by means of negative feedback. The proposed topology also ensures stability when amplifier gain is varied. Furthermore, effective input capacitance of the TIA is reduced by using a positive capacitive feedback. The circuit is intended for intermediate frequency (IF) over fiber systems, but

The minimization of a functional consisting of a combined L 1/L 2-data-fidelity term and a total variation term, named L 1-L 2-TV model, is considered to remove a mixture of Gaussian and impulse noise in images, which are possibly additionally deformed by some convolution operator. We investigate analytically the stability of this model with respect to its parameters and link it to a constrained m

This paper assesses water quality that is used for vegetable irrigation in Tamale Metropolis, Ghana. A mixed-method of research design was employed in this study to collect and analyze the data based on survey instruments. The paper found that Escherichia coli (E. coli) that is usually used as an indicator of water contamination and heavy metals exist in all taken water samples. The mean concentra

INTRODUCTION: A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a common scale to better aid the diagnosis and prognosis of Alzheimer's disease (AD) and to monitor anti-amyloid therapeutic interventions. Here, we apply the Centiloid method to [18

Every of the seven chapters of the course aims at introducing the students to the basics of Romanian language in the larger context of the Romanian culture and civilization development, with the ultimate purpose of settling both a few essential theoretical knowledge and some practical communication skills for the foreign students as inhabitants of Romania. The compulsory tasks at the end of each c

Adaptive and flexible approaches based on implementing different measures as new information emerges have been proposed as a way of enabling robustness towards uncertain future climate change. However, the success of flexible approaches in practice depends on the stability of the relevant organizational landscapes. In this paper, we draw upon key insights from the institutional theories of organiz

987/5000En omfattande ram för en hållbar renoveringsprocess med en helhetssyn på renovering har utvecklats med beaktande av områdena: teknik, miljö, ekonomi, sociala värden och arkitektur och kulturhistorisk miljö. Ramverket beskriver aktiviteter som ska genomföras i olika steg i processen, samt kartlägger vem som kommer att ansvara för och utföra dessa aktiviteter. Ramverket hänvisar till tillgänA comprehensive framework for a sustainable renovation process with a holistic approach to renovation has been developed, taking into consideration the areas: technology, environment, economy, social values, and architecture and cultural historical environment. The framework describes activities that should be carried out at different stages of the process, as well as charting who will be responsi

Unmanned Aerial Vehicles (UAVs) equipped with high-resolution image recording devices have found recent application in performing inspection and surveillance of buildings, bridges, wind parks and other civil infrastructure systems. With the concept of equipping a UAV with NDE equipment, possibilities are created for new research areas in the field of structural health monitoring, where a limited n

Spectral analysis encompasses several powerful signal processing methods. The papers in this thesis present methods for finding good spectral representations, and methods both for stationary and non-stationary signals are considered. Stationary methods can be used for real-time evaluation, analysing shorter segments of an incoming signal, while non-stationary methods can be used to analyse the ins

Viral etiology of nasal polyps was postulated as many as 40 years ago, but so far, no study has shown an association or causal relation between any specific virus and nasal polyps. By using the polymerase chain reaction (PCR) technique, nasal polyps from both 10 patients with intolerance to nonsteroidal anti-inflammatory drugs (NSAID intolerance) (e.g., Aspirin) and from 10 patients with no histor

Hematopoiesis serves as a paradigm for how homeostasis is maintained within hierarchically organized cell populations. However, important questions remain as to the contribution of hematopoietic stem cells (HSCs) toward maintaining steady state hematopoiesis. A number of in vivo lineage labeling and propagation studies have given rise to contradictory interpretations, leaving key properties of ste

In this study, grey cast iron disc brake rotors are refurbished by adding a surface layer through laser cladding. Current methods to deal with replaced rotors mainly include remelting, with a minority fraction disposed in landfill. Both approaches result in a huge waste of resources and an increase in CO2 footprint. From a sustainable point of view, this study aims to evaluate the feasibility of r

It has become necessary to estimate the quantities of runoff by knowing the amount of rainfall to calculate the required quantities of water storage in reservoirs and to determine the likelihood of flooding. The present study deals with the development of a hydrological model named Hydrologic Engineering Center (HEC-HMS), which uses Digital Elevation Models (DEM). This hydrological model was used

Purpose: The COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic. Methods: We used Delphi method with a nine-scale

Denna artikel bygger på aktuell internationell forskning samt en webbaserad enkätundersökning i ett samarbete mellan Ekonomihögskolan vid Lunds universitet och intervjuföretaget Norstat.