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The risk for celiac disease (CD) is clearly related to specific HLA DQA1 and DQB1 alleles, but HLA -typing is often considered too costly for frequent use.Here we present a method using sequence-specific primed PCR (PCR-SSP) for HLA-DR-DQ genotyping optimized for capillary electrophoresis on Applied Biosystems 3130xl Genetic Analyzer. Requiring a total of three PCR reactions and a single electroph
OBJECTIVES: To study changes in use of fall-risk increasing drugs (FRIDs) and bone density-related medication in participants with hip fracture before and after the fracture and to analyze differences between five healthcare districts. DESIGN: Population-based cohort study. SETTING: Data retrieved from two national databases PARTICIPANTS: All 2,043 people with hip fracture aged 60 and older in a S
PURPOSE: Asthma includes immunological components that may share mechanisms with autoimmune diseases. We analyzed the subsequent occurrence of any of 22 autoimmune and related conditions in hospitalized asthma patients. METHODS: A nationwide study was conducted in Sweden on subsequent diseases of asthma patients on the basis of the Hospital Discharge Register. Standardized incidence ratios (SIRs)
Popular AbstractAvhandlingen tar sin empiriska utgångspunkt i en analys av hur historiskt betingade värden hanteras i samtida planering samt natur- och kulturmiljövård. Syftet är att därigenom förtydliga förutsättningarna för en hållbar landskapsutveckling avseende landskapets historiska värden. Analysen tar sin teoretiska utgångspunkt i tidsgeografi och kritisk realism. Perspektiven har använts fThis thesis is based on an analysis of how historically motivated values are treated in contemporary planning- and conservation practices. The aim is to discuss the premises of a sustainable landscape development regarding historical landscapes and heritage. The analysis takes its theoretical point of departure in time-geography and critical realism. These perspectives have been used to develop a
Nigeria has the highest number of AIDS-related deaths in the world. In this study, we characterised the HIV-1 molecular epidemiology by analysing 1442 HIV-1 pol sequences collected 1999-2014 from four geopolitical zones in Nigeria using state-of-the-art maximum-likelihood and Bayesian phylogenetic analyses. The main circulating forms were the circulating recombinant form (CRF) 02_AG (44% of the an
Red Cell Distribution Width (RDW) could be a risk factor for developing various chronic diseases, and seems to be a prognostic marker in patients with cardiovascular disease (CVD) or cancer. Our aim was to explore the association between RDW and all-cause and cause-specific mortality in a general population. RDW was measured in 27,063 participants (aged 45-73 years) from the population-based Malmö
INTRODUCTION: Despite much literature on reference values of acid-base status in umbilical cord blood at birth, there are as yet no studies performed to determine gestational age-dependent references in cord venous blood and no studies on preterm acid-base standards. Similarly, the normal reference range of Apgar scores for term and preterm infants has not yet been determined.MATERIAL AND METHODS:
During the #metoo movement in the autumn of 2017, stories about sexual assault, including rape, garnered much attention worldwide. It might seem as if all of these stories came from nowhere. In fact, during the last decades several rape cases have been highlighted and debated in media all over the world. These discussions in the media and among the general public have led to scrutiny and a critica
A polymer electrolyte fuel cell (PEFC) is an electrochemical device that converts chemical energy directly to electrical energy, and its performance greatly depends on its operating temperature. Therefore, in this paper, a novel thermodynamic PEFC model with the airflow cooling method is firstly developed for the PEFC system. Then, a novel model predictive control (MPC) controller is designed to c
The photoionization of xenon atoms in the 70–100 eV range reveals several fascinating physical phenomena such as a giant resonance induced by the dynamic rearrangement of the electron cloud after photon absorption, an anomalous branching ratio between intermediate Xe+ states separated by the spin-orbit interaction and multiple Auger decay processes. These phenomena have been studied in the past, u
The use of protective barriers to isolate a metal surface from an aggressive environment is a common way to inhibit its degradation. We used ambient pressure x-ray photoelectron spectroscopy to assess in real time the evolution of the copper surface and the contextual protective action of 2D material coatings (graphene and hexagonal boron nitride) towards copper oxidation. In an isobaric experimen
Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are associated with HCC development, using biological samples
A method for the electrochemical synthesis of palladium nanowires, using porous alumina templates with diameters of 25 nm and 40 nm, is presented. Through an electrochemical barrier layer thinning step, pulsed electrodeposition can take place directly into the anodized aluminum; without need for extra removal, pore opening, and metal contact coating steps. A digital oscilloscope is used to record
High energy surface x-ray diffraction (HESXRD), x-ray reflectivity (XRR), mass spectrometry (MS) and surface optical reflectance (SOR) have been combined to simultaneously obtain sub-second information on the surface structure and morphology from a Pd(100) model catalyst during in situ oxidation at elevated temperatures and pressures resulting in Pd bulk oxide formation. The results show a strong
The association between contextual factors and health inequalities is well documented, also in Brazil. However, questions about how contextual factors actually affect health and well-being persist. The aim of this qualitative study was to explore how contextual factors-i.e., social stratification and neighborhood opportunity structures-are manifested in the lives of the residents of a vulnerable d
BACKGROUND: The four-kallikrein (4K) panel has been demonstrated to improve prediction of aggressive prostate cancer compared with prostate-specific antigen (PSA) among men with moderately elevated PSA levels. However, the development and testing of the 4K panel has been conducted primarily in White men, with limited data in African Americans and no studies in other racial and ethnic groups. METHO
