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Work and working conditions are fundamental social determinants of health. Climate change poses an urgent and growing threat to workers' health, through both direct exposure to environmental hazards and indirect exacerbation of social and health inequalities. Occupational health, which focusses on the promotion of mental and physical health and well-being of workers, is a key but often overlooked

Cubosomes─colloidal dispersions of lipid inverted bicontinuous cubic phases─are promising nanosystems for advanced drug delivery applications. Here, we report on a microfluidic hydrodynamic flow-focusing approach for solvent exchange that enables the preparation of cubosomes with tunable size. The approach involves a preliminary step where the lipid phytantriol, the main building block, is first d

Objective: Survivors of childhood, adolescent, and young adult (CAYA) cancer have an increased risk of metabolic syndrome (MetS). MetS describes the clustering of cardiovascular risk factors including overweight or obesity, hypertension, (pre)diabetes, and dyslipidaemia. While associated cardiovascular sequelae can be serious, MetS is preventable, manageable, and potentially reversible with the ap

Certified randomness guaranteed to be unpredictable by adversaries is central to information security. The fundamental randomness inherent in quantum physics makes certification possible from devices that are only weakly characterized, i.e., requiring little trust in their implementation. It was recently shown that the amount of certifiable randomness can be improved using the so-called entropy ac

ObjectiveTo compare speech outcomes in 4 groups of 5-year-olds with cleft of the hard and soft palate: with Robin sequence without additional conditions (RS−), with Robin sequence with additional conditions (RS+), without Robin sequence with additional conditions (CP+), and without Robin sequence without additional conditions (CP−).DesignRegistry-based cohort study.SettingRegional public care univ

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with a heterogenous clinical picture. This study aimed to link genetic SLE predisposition with relevant clinical manifestations. Method: Datasets best corresponding to the 11 American College of Rheumatology 1982 (ACR-82) classification criteria for SLE in a large, public database (FinnGen consortium, >218,000 individuals) wer

Background: This study aimed to compare the effect on postoperative complications of combined prehabilitation targeting predefined co-existing risky SNAP factors with usual preoperative routines in surgical patients. Methods: This systematic review followed the PRISMA 2020 guideline and the protocol (CRD42022282611). Five databases were searched from inception to November 7, 2022 for randomised co

Context: Chronic dyspnea is subjective but with objective (measurable) consequences. It is often poorly assessed because people have modified their lifestyles to avoid exertion that generates dyspnea. Objectives: This study sought any relationship between respondents’ self-reported long-term breathlessness limiting exertion (hereafter chronic dyspnea) and distance travelled from the room in which

Background: Chronic low-grade inflammation is a well-known risk factor for coronary heart disease (CHD) and future cardiovascular events. Anti-inflammatory therapy can reduce the risk of ischemic cardiovascular disease (CVD) events following myocardial infarction (MI). However, it remains unknown to what extent inflammation at the time of an acute event predicts long-term outcomes. We explored whe

Objectives. This study aimed to estimate the prevalence of atrial fibrillation (AF) and identify its associated comorbidities in adults aged 45 years and older, using data from the Swedish general population study EpiHealth. Design. In a cross-sectional design, data of health history, lifestyle factors, anthropometric measurement, and 1-lead ECG recordings from participants in the EpiHealth study

Violent offenders are a heterogeneous group where criminogenic needs often are substantial and violent behaviors persistent. Risk, Need, and Responsivity (RNR)-based treatment has shown effect on reducing the risk for recidivism in violent crime, but the development of novel treatments is crucial in making the change process more effective. Virtual Reality (VR) technology may be a tool to improve

Lead-free perovskites (LFPs) are an emergent class of materials with great potential as next-generation candidates for energy and optoelectronic applications, offering a sustainable and non-toxic alternative to their lead-based counterparts. Computational studies play a central role in accelerating the discovery, design, and optimization of these materials by enabling predictive insights into elec

BackgroundLong-term oxygen therapy (LTOT) given for at least 15 hours/day improves survival in patients with severe chronic hypoxemia. However, the recent REDOX trial showed that LTOT prescribed for 24 hours/day was not superior to 15 hours/day in terms of death, hospitalizations, or self-reported outcomes. We aimed to examine the cost effectiveness of prescribing LTOT for 24 versus 15 hours/day.M

The primary regulator of testicular function is the gonadotropin-releasing hormone (GnRH). This hormone is secreted in a pulsatile manner by hypothalamic neurons. GnRH stimulates the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. LH stimulates the synthesis of testosterone (T) after binding to specific receptors on Leyd

Introduction: Postnatal pesticide exposure and its impact on executive functioning (EF) in children and adolescents remains underexplored, particularly in African agricultural contexts. This study investigated associations between urinary pesticide biomarkers and EF in the Child health Agricultural Pesticide study in South Africa (CapSA). Methods: Data from 445 participants (mean age: 10.6 years;

BackgroundOsteocalcin is a bone-specific protein involving many physiological processes, primarily bone turnover. Also closely related to the musculoskeletal system is the frailty syndrome.AimTo investigate if circulating osteocalcin levels and frailty are associated in the old, and in addition, if the presumed association is mediated through alterations in bone.Methods999 community-dwelling women

In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal antibodies—a deeper understanding of how inflammatory a

Natural products originating from microorganisms have been an important source of many successful lead molecules in the drug discovery and development process. The technological advances in analytical instrumentation and the development of various omics methodologies have provided new opportunities to accelerate the discoveries of new lead structures of microbial origin. Metabolomics is a rapidly