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Objectives: In radiotherapy, delineation uncertainties are important as they contribute to systematic errors and can lead to geographical miss of the target. For margin computation, standard deviations (SDs) of all uncertainties must be included as SDs. The aim of this study was to quantify the interobserver delineation variation for stereotactic body radiotherapy (SBRT) of peripheral lung tumours

Permafrost regions contain approximately half of the carbon stored in land ecosystems and have warmed at least twice as much as any other biome. This warming has influenced vegetation activity, leading to changes in plant composition, physiology, and biomass storage in aboveground and belowground components, ultimately impacting ecosystem carbon balance. Yet, little is known about the causes and m

In the light of recent developments in the design of structural materials, micro-architected heterogenous-structure metals are considered among most structurally efficient. In this work, a new technique for Local High Pressure Torsion (L-HPT) enabling the creation of heterogeneous structures through localised deformation processing in sheet metals by impeding a rotating punch is proposed. Using AA

Despite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 an

Power Factor Correction (PFC) converters are essential in designing any charging architecture, regardless of the battery's capacity and the application. Nevertheless, power converters, having continuous output current features, are widely used for battery charging applications. In contrast, converters with continuous input current characteristics exhibit better PFC performance. The Cuk converter c

BackgroundThe clinical standard practice of [177Lu]Lu-PSMA-617 therapy is a single injection per treatment cycle, with 6 weeks between cycles. While clinical schedules currently utilize single-bolus cycles, splitting a treatment cycle into multiple smaller injections has demonstrated benefits in other radionuclide therapies, preclinically and in clinical studies. Potential mechanisms for improved

Recent years have seen a rise in extreme heat event (EHE)-related deaths in India. However, the impact of specific temperature thresholds on health risks remains understudied. Using Distributed Lag Non-Linear Models (DLNM), we explored the link between EHEs, defined by various temperature thresholds, and mortality risk in Ahmedabad, India, from 2002 to 2018, considering a 21-day lag. We observed a

Methods: Drug-induced interstitial lung disease (ILD) is crucial to detect early to achieve the best treatment outcome. Optimally, non-invasive imaging biomarkers can be used for early detection of disease progression and treatment follow-up. Therefore, reliable in vivo models are warranted in new imaging biomarker development to accelerate better-targeted treatment options. Single-dose bleomycin

A literature review and statistical analysis of the potential of agricultural residual waste as building materials in South Sweden was carried out. This data showed that there is a clear capacity for the use of mainly straw-generating crops as building materials in the region.

Background: In the laparoscopic Roux-en-Y gastric bypass procedure, the gastrojejunal stoma is constructed with either a circular (CSD) or a linear stapling device (LSD). The diameter of the stoma following stapling with the 21 mm CSD is expected to be approximately 12 mm (diameter of the anvil). Measuring the stoma diameter after linear stapling is a little more complex since the remaining openin

BACKGROUND: The elapsed time taken to diagnose tumors of the central nervous system in children and adolescents varies widely. The aim of the present study was to investigate such diagnostic time intervals at a national level in Sweden as they correlate with clinical features.METHODS: Data prospectively accumulated over a 4-year period in the Swedish Childhood Cancer Registry from patients aged 0-

Background: Hypotension is common after cardiac arrest (CA), and current guidelines recommend using vasopressors to target mean arterial blood pressure (MAP) higher than 65 mmHg. Pilot trials have compared higher and lower MAP targets. We will review the evidence on whether higher MAP improves outcome after cardiac arrest. Methods: This systematic review and meta-analysis will be conducted based o

I Sverige finns det 335 500 hästar enligt Statistiska centralbyrån. Hästsporten är växande och handeln med tävlingshästar har kommit att utgöra en stor del av hästbranschens levebröd. Beroende på om säljaren bedöms vara näringsidkare eller privatperson så blir olika lagar tillämpliga vid en hästförsäljning. Som näringsidkare har säljaren enligt konsumentköplagen (1990:932) ett mycket långtgående a

This thesis analyzes the legitimacy of the United States’ sanctions against Cuba during the Cold War from a human rights perspective. It applies four theoretical frameworks: John Locke’s natural rights theory, Marxism, liberal internationalism, and the UN Charter. Using an idea analysis method, the study examines how these frameworks interpret the purpose, means, and effects of the sanctions. Empi

Examensarbetets titel: Sluta shoppa – men köp av oss: En studie om hur Askets normbrytande anti-konsumtions-kommunikation uppfattas i en tid av fast fashion Seminariedatum: 3:e juni 2025 Kurs: FEKH29, Examensarbete i marknadsföring på kandidatnivå, 15 högskolepoäng Författare: Ellen Christofi Johansson, Melinda Nord & Saga Petersson Handledare: Peter Svensson Nyckelord: Anti-konsumtiTitle: Stop Shopping – But Shop From Us: A study about how Asket’s norm-breaking anti-consumption communication is perceived in a time of fast fashion Seminar date: June 3rd 2025 Course: FEKH29, Degree Project Undergraduate level, Business Administration, Undergraduate level, 15 Credits Authors: Ellen Christofi Johansson, Melinda Nord & Saga Petersson Advisor: Peter Svensson Keywords

High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer, often discovered in advanced stages and linked to poor survival. Due to high mortality rates, there is a need for novel treatment strategies. A promising new strategy is induction of ferroptosis, which has recently been shown to synergistically induce cell death in HGSOCs in combination with MTDH-SND1 protein

Ovarian cancer is the most lethal gynecological malignancy, with treatment heavily relying on platinum-based chemotherapy. However, resistance frequently develops, posing a major clinical challenge that underscores the need for new approaches. In this study, we investigated the phosphoproteomic landscape underlying cisplatin resistance, which remains poorly understood. A parental CAOV3 ovarian can

Background: Effectively identifying individuals exposed to drug underuse, overuse and potentially inappropriate medication (PIM) in older adults is essential for minimizing preventable drug-related harms. Methods: We analysed data from 54,296 individuals aged 60–74 years from the German National Cohort (NAKO). We assessed the frequency of PIM, untreated conditions (medication and vaccination under