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Knowledge about the nature, processes and patterns of cascading effects, i.e. where infrastruc-ture dependencies lead to impacts propagating from one system to other systems, is essential in order to miti-gate and respond to crises that involve critical infrastructures and societal functions. This paper presents a method for systematic description of cascading effects in past event, to some extent
Thread-Level Speculation can be used to take advantage of multicore architectures for web applications. We have implemented Thread-Level Speculation in the state-of-the-art JavaScript engine V8 instead of using an interpreted JavaScript engine. We evaluate the implementation with the Chromium web browser on 15 popular web applications for 2, 4, and 8 cores. The results show that it is beneficial t
It is widely accepted that firms in peripheral regions benefit to a lesser extent from local knowledge spillovers than firms located in agglomerations or industrial clusters. This paper investigates the extent to which innovative firms in peripheral regions compensate for the lack of access to local knowledge spillovers by collaborating at other geographical scales. So far the literature predomina
Newton-Raphson and Goldschmidt algorithms can be sped up by using variable latency hardware architectures for rounding division, square root and their reciprocals. A new approach based on a rounding method with remainder estimate calculated concurrently with the algorithm was proposed in [5]. This paper presents an study of the hardware implementation of this approach and shows that does not suppo
Expression microarray analysis identified over 930 genes regulated during puberty in the mouse mammary gland. Most prominent were genes whose expression increased in parallel with pubertal development and remained high thereafter. Members of the Wnt, transforming growth factor-beta and oestrogen-signalling pathways were significantly overrepresented. Comparison to expression data from CITED1 knock
To obtain full sky coverage, astronomical adaptive optics systemsrequire Na Sodium Beacons (SBs) (also referred to as Laser Guide Starsor LGSs) located at heights extending from 85 to 100 km. When viewed atthe edge of large telescopes these SBs appear elongated. For the Euro5050 meter aperture telecopes this elongation amounts to 6 to 9 arcsecondswhen the laser is launched from a point on the tele
The ctaBCDEF genes coding for cytochrome c oxidase were found to reside adjacent to a regulatory gene ctaA at 127-degrees on the Bacillus subtilis chromosome. The structural genes for subunits I and II, ctaD and ctaC, were deleted by gene-replacement using a phleomycin-resistance marker. The mutant was unable to oxidize N,N,N',N'-tetramethyl-p-phenylenediamine and oxidized cytochrome c at a signif
A multiscale modeling framework for polycrystal materials is established, using a combination of an extended vertex model and a crystal plasticity formulation. The 2D vertex model is cast to incorporate a range of mesoscale processes such as grain structure evolution and the influence of second-phase particles. It is combined with a finite strain crystal plasticity formulation whereby also texture
In this manuscript, a new strategy has been reported for circumscribed covalent attachment of barbed and pointed ends of actin filaments to polystyrene beads. A comparative study of attachment of actin filaments to polystyrene beads was performed by blocking functionally active sites on polystyrene beads with nonionic detergents such as Tween 20, Tween 80 and polyethylene glycol (PEG). Effective b
An amperometric immunoanalysis system based on monoclonal antibodies immobilized on Sepharose beads and packed into a micro-immunocolumn was developed for the quantification of microcystin-LR. Microcystin-LR (MCLR) was used as a reference microcystin variant. Inside the immunocolumn, free microcystins and microcystin-horseradish peroxidase (tracer) were sequentially captured by the immobilized ant
Biocompatible nanoparticles possessing fluorescent properties offer attractive possibilities for multifunctional bioimaging and/or drug and gene delivery applications. Many of the limitations with current imaging systems center on the properties of the optical probes in relation to equipment technical capabilities. Here we introduce a novel high aspect ratio and highly crystalline europium-doped c
Background Peer review is important to the scientific process. However, the present system has been criticised and accused of bias, lack of transparency, failure to detect significant breakthrough and error. At the British Journal of Surgery (BJS), after surveying authors' and reviewers' opinions on peer review, we piloted an open online forum with the aim of improving the peer review process. Met
S100 protein is a marker for brain damage easily analysed in blood. The serum level immediatly after termination of extracorporeal circulation (ECC) is increased and associated to age and the duration of perfusion. A prolonged residual concentration indicates cellular brain damage. The objective of this study was to ascertain if the prognosis of individual patients, with stroke following ECC, coul
We consider designing demodulators for linear vector channels that use reduced-size trellis descriptions for the received signal. We assume an iterative receiver and use interference cancellation (IC) with soft-information provided by an outer decoder to mitigate the signal part that is not covered by a reduced-size trellis description. In order to reach a trellis description, a linear filter is a
The Environmental Determinants of Diabetes in the Young (TEDDY) is an international study aiming to investigate associations between dietary and other environmental factors and the risk of developing islet autoimmunity and type 1 diabetes. Dietary intake was assessed using a 24-h recall and repeated 3-day food records and analyzed using country-specific food composition databases (FCDBs) in Finlan
β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycan (GAG) chains. Natural and synthetic xylosides can be used to both inhibit and prime GAG synthesis by acting as inhibitors or substrates for β4GalT7. In this report, we exploit hydroxylated oxanes as deoxygenated xyloside analogs to clarify the minimum protein-ligand interactions required for galactosyl
