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Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN
Epitaxially grown nanowires have shown promise for photovoltaic applications due to their nanophotonic properties. Moreover, the mechanical properties of nanowires can reduce crystallographic defect formation at interfaces to help enable new material combinations for photovoltaics. One material that stands to benefit from the nanowire morphology is zinc phosphide (Zn3P2), which, despite promising
We face closely intertwined crises related to biodiversity, climate change, global health andinequality. Unfortunately, the knowledge that could help overcome these existential crises isscattered across millions of scientific articles, reports, policy documents, databases, andindividual datasets, far exceeding human processing capabilities. This hinders evidence-basedresearch, innovation and polic
Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyloidogenic disorders such as Alzheimer's and Parkinson's diseases. However, the description of biologically relevant processes may require rate equations that are too complex to solve using existing methods, hindering mec
This study investigates understandings of the concept of ‘participation’ within the context of a Swedish school, focusing on the differing perspectives of teachers, students, and school leaders. Despite a long-standing tradition in Sweden of recognizing children’s rights to influence their education, there remains considerable variation in how participation is understood and implemented among variThis study investigates understandings of the concept of ‘participation’ within the context of a Swedish school, focusing on the differing perspectives of teachers, students, and school leaders. Despite a long-standing tradition in Sweden of recognizing children’s rights to influence their education, there remains considerable variation in how participation is understood and implemented among vari
Alkanolamides are biosurfactants used in a range of products for cleaning and other applications. Recently, an environmentally benign and volume-efficient biocatalytic process for production of high-quality alkanolamides was developed in our laboratory. In the current investigation, this process is evaluated in terms of technical and economic feasibility on a multi-tonne scale using commercial pro
Objective: To analyze screening for retinopathy of prematurity (ROP) during a 3-year period in a national cohort of infants born before 27 weeks' gestation. Methods: A national prospective study of neonatal morbidity in extremely preterm infants was performed in Sweden between April 1, 2004, and March 31, 2007. Screening for ROP was to start in the fifth postnatal week and to continue weekly until
Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activi
We show that the principally two-dimensional (2D) scanning tunneling microscope (STM) can be used for imaging of 1D micrometer high free-standing nanowires. We can then determine nanowire megahertz resonance frequencies, image their top-view 2D resonance shapes, and investigate axial stress on the nanoscale. Importantly, we demonstrate the extreme sensitivity of electron tunneling even at very hig
We consider simple approximations of variances and covariances for order statistics from the standard extreme value distribution. Exact values and simulation results of the variances and covariances for certain sample sizes are used to determine the validity of the suggested approximations.
Spectra of far-infrared conductivity contain useful information on charge transport at nanoscopic length scales. However. decrypting the mechanisms and parameters of charge transport from the measured spectra is a complex task in nanostructured systems in particular, the conductivity is strongly influenced by charge carrier interaction with surfaces or interfaces between constituents of the compos
We present a framework based on object orientation with novel principles for how to store, analyze and integrate electrophysiological data. These principles are: (I) Using a Decorator pattern for storing analysis data in an object model, (II) using a Core Classes data structure for integration through mediation in a service bus architecture, and (III) choosing the single unit as the finest structu
Popular Abstract in English An increased risk of pre-cancer lesions of the cervix among HIV-infected women, and the positive impact of HIV treatment on its outcome has been reported globally. However there is paucity of information from west Africa with genetically distinct viral strains. Considering that HIV strains differ in the rate and pattern of HIV disease progression, a different outcome isBackground: The highest numbers of HIV-infected women are in sub- Saharan Africa, where the natural progression of HIV disease in the absence of treatment results in death before the onset of invasive cervical cancer. With improved access to treatment, several studies outside West Africa demonstrated an increased risk of pre-invasive cervical lesions among HIV-infected women and the positive impac
Background: Ensiling is a common method of preserving energy crops for anaerobic digestion, and many scientific studies report that ensiling increases the methane yield. In this study, the ensiling process and the methane yields before and after ensiling were studied for four crop materials. Results: The changes in wet weight and total solids (TS) during ensiling were small and the loss of energy
A matched filter composed of a time lagged feedforward artificial neural Network (TLFN) and a pulse-shaping filter is used in a noisy environment to detect R-waves for pacemakers. The TLFN reduces the influence of lower frequencies in the invasive electrogram (EGM) signals, e.g. P and T waves, and conditions the EGM to optimize the performance of the dynamically updated matched filter. Detector pe
BACKGROUNDPerinatal factors including high birth weight have been found to be associated with acute lymphoblastic leukemia (ALL) in case-control studies. However, to the best of our knowledge, these findings have seldom been examined in large population-based cohort studies, and the specific contributions of gestational age and fetal growth remain unknown. METHODSThe authors conducted a national c
