Sökresultat

The water-energy-food nexus is now a popular approach in the sustainability field. However, whereas the nexus calls for more holistic, inter- and transdisciplinary approaches, the research produced over the past decade has been fragmented and specialized. Furthermore, there is still a gap between the nexus as a descriptive and analytical concept and its operationalization. Nexus research needs a s

Background: Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of afor

Metal halide perovskites are promising optoelectronic materials. Their electronic properties however are rather unstable which is often assigned to ion migration. Ion migration can be readily influenced by an electric field (EF). Here, the response of photoluminescence (PL) of individual MAPbX3 (MA = CH3NH3, X = I, Br) sub-micrometer-sized polycrystals to EF is studied. Alternating EF with frequen

Objectives: Patients with Staphylococcus aureus bacteraemia (SAB) at risk for infective endocarditis (IE) need to be identified because they should undergo echocardiography. We validated previous scoring systems for IE risk determination and evaluated whether time to blood culture positivity (TTP) could improve scoring systems. Methods: This retrospective population-based study included adults wit

Aims Endotypes integrate individual clinical and molecular data and can be used to formulate molecular subclassifications of diseases. We previously derived four endotypes of subclinical carotid atherosclerosis in a large European cohort, c-IMT and c-IMT Progression as Predictors of Vascular Events in a High-Risk European Population (IMPROVE), identifying individuals with a specific cardiovascular

Background Prothrombin is a vitamin K-dependent glycoprotein synthesized in the liver and circulating in blood as an inactive zymogen. The corresponding activated thrombin enzyme is a central player in hemostasis and thrombosis. Still, little is known about the individual variation over time of the prothrombin concentration in plasma in the general population. Objectives This study aimed to establ

Background: Chronic limb-threatening ischaemia (CLTI) causes high rates of amputation and mortality. Objectives: To compare incidence, management and prognosis in hospitalised patients with CLTI with and without diabetes mellitus (DM) in 2001 and 2023. A secondary objective was to compare adherence to global vascular guidelines on risk factors between patients with and without DM in 2023. Design:

Accumulating evidence suggests that a compromised intestinal epithelial barrier (IEB) contributes to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD); however, the exact mechanisms remain unclear. Here we reveal that intestinal mucin 1 (MUC1) levels and glycosylation are decreased in both humans and male mice with MASLD. Enterocyte-specific Muc1 knockout aggravat

The present study aimed to increase understanding of how singing activities may be initiated in primary school, and what support and assistance teachers require to conduct singing activities as an integrated part of the school day. Five music teachers participated in a focus group interview. The following main themes were identified: 1) pedagogical and methodological flexibility, 2) the role of ro

Out-of-pocket (OOP) expenditures for childbirth in Bangladesh have increased substantially, intensifying financial pressure on lower-income households. While wealthier groups historically bore higher delivery costs, recent trends indicate a narrowing gap in spending across socioeconomic strata. This study investigates the drivers of this convergence in delivery-related expenditures between 2014 an

BackgroundWomen’s empowerment may influence non-communicable disease (NCD) risk. However, evidence on these associations among women in Bangladesh remains limited. This study examined the associations between women’s empowerment and the prevalence of selected non-communicable conditions among ever-married reproductive-aged women in Bangladesh.MethodsData from the 2022 Bangladesh Demographic and He

BACKGROUND: Accreditation of cancer centres aims to deliver high-quality, person-centered care and underscores the integration with education, research, and innovation. Over the past decade, cancer centres in the Nordic countries have engaged in accreditation processes through the Organisation of European Cancer Institutes (OECI).OBJECTIVE: This study provides an overview of a rapidly evolving lan

Nucleotides and coenzymes play critical roles in energy metabolism and cellular signaling and as building blocks of nucleic acids. This work addresses the challenges in the measurement of the phosphorylated metabolites using hydrophilic interaction liquid chromatography coupled with mass spectrometry, which facilitates the separation and detection of polar metabolites. Here, we present optimized H

Background and aims: We examined whether the excess cardiovascular disease (CVD) risk among adults with steatotic liver disease (SLD) subtypes could be reduced or eliminated through joint control of low-density lipoprotein cholesterol (LDL-C), lipoprotein(a) [Lp(a)], and high-sensitivity C-reactive protein (hs-CRP). Methods and results: This prospective cohort study included 291,995 participants f

Early-life adversity negatively affects morbidity and survival in late life, but knowledge is limited about effects on women’s reproduction and reproductive health. To deepen our understanding of the full effects of disease exposure in early life, including long-term consequences, we study women’s reproductive outcomes and their offspring’s health. Using the Scanian Economic Demographic Database a

Bacteriophages exert strong selective pressure on bacterial populations and play a central role in shaping microbial evolution. In response to phage predation, bacteria have evolved diverse antiphage defence mechanisms that interfere with viral replication through a wide range of molecular strategies. Recent genomic studies have revealed a rapidly expanding repertoire of candidate defence systems,

Abstract INTRODUCTION Countries have varying, limited healthcare budgets for emerging disease-modifying therapies. Cost-effectiveness analysis, combined with country-level cost-effectiveness thresholds, can be used to estimate value-based prices (VBPs) for lecanemab and donanemab across 174 countries. METHODS The cost-effectiveness of lecanemab and donanemab was estimated using incremental cost an

Context: Life satisfaction (LS) is associated with health and longevity but decreases after spinal cord injury (SCI). Yet, little is known about changes in LS over time, many years after SCI. Objectives: To assess changes in LS over six years among older adults aging with long-term SCI, determine how changes in LS are associated with sex, age, injury characteristics, and with changes in secondary