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Polymer gel dosimetry with MRI-readout for 3D dose verification - detector characteristics and clinical applications

Strålbehandling är en viktig behandling av cancer och det är avgörande att ge de föreskrivna stråldoserna exakt på rätt plats för att lyckas. Innan en patient behandlas verifieras strålbehandlingen genom kontrollmätningar. Dessa kontrollmätningar utförs med små detektorer som är placerade i ett fantom. Dessa mäter dosen endast i de punkter där de placeras. Stråldosen som ligger mellan dessa punkteBackground & Purpose: Radiation therapy is an essential treatment for cancer patients with the ultimate goal to deliver radiation doses to the tumour with precision while minimizing exposure to surrounding healthy tissues. Treatment verification is crucial to ensure the accuracy of radiation delivery, for instance by measuring the radiation dose distribution. Among various dosimetry techniques

Grund för att återkalla ett permanent uppehållstillstånd

Att återkalla ett permanent uppehållstillstånd är ett mycket ingripande beslut som kan påverka den enskildes trygghet. Av den anledningen ska den en-skildes trygghet och stabilitet alltid beaktas när ett sådant beslut fattas. Konsekvenserna av att återkalla ett permanent uppehållstillstånd kan vara att personen inte längre har rätt att resa in i Sverige utan visum och att personen inte längre är fRevoking a permanent residence permit is a highly intrusive decision that can affect the individual's security. For this reason, the individual's security and stability should always be taken into account when making such a deci-sion. The consequences of revoking a permanent residence permit may in-clude the person no longer having the right to enter Sweden without a visa and no longer bei

Optimal Discharge from a Hydropower Plant for Fish Reproduction: An Aquatic Habitat Model

Vattenkraft är den dominerande källan till elektricitet i Sverige, med ett bidrag på 45% av den nationella produktionen. Samtidigt som vattenkraften är avgörande för utfasningen av fossila bränslen och för klimatmålen, är dess miljöpåverkan på den biologiska mångfalden i sötvatten oroande. I denna fallstudie av ett vattenkraftverk i Helge å, var syftet att hitta ett lämpligt flöde för reproduktionHydropower is the dominant source of electricity in Sweden, constituting 45% of the national supply. While pivotal for decarbonization and climate goals, its environmental impact on freshwater biodiversity is concerning. In this case study of a hydropower plant in Helge River, Sweden, the aim was to find a flow suitable for trout (Salmo trutta) and salmon (Salmo salar) reproduction. A terrain mode

Increasing constraints? Civil society organisations in Jordan vis-à-vis the state

The Jordanian state apparatus is increasingly limiting civil society in Jordan from engaging in open debate, and organisations are gradually inhibited from executing their activities and events. These are the premises on which this research is based, and in exploring them several questions arise. How can civil society in Jordan be characterised and applied? What do these obstacles look like in pra

BIM i förvaltningen

The study has shown that BIM is used extensively throughout the entire construction process, with clear benefits and optimizations. The broad usage of BIM shows that all areas have streamlined and become less costly. BIM is well established in the construction process with an exception for the facility management phase. The benefits in the facility management area are well studied but not introduc

The Business Model for Sustainability from a System Dynamics Perspective

Title: System Dynamics Perspective on the Business Model for Sustainability: A Multiple Case Study in the Architecture Industry Purpose: The primary purpose of the study is to explain how the system dynamics between the Value Configuration, Partner Network, and Capabilities work in a Business Model for Sustainability of small and large architecture firms. Methodology: We followed an abductive, q

Detecting bark beetle damage with Sentinel-2 multi-temporal data in Sweden

The European spruce bark beetle is considered as one of the most destructive forest insects to Norway spruce trees in Europe. Climate change may increase the frequency and intensity of bark beetle outbreaks. It is therefore of vital importance to detect the bark beetle outbreaks and take it under control to prevent further damages. Remote sensing techniques may provide a cost-efficient solution to

The Principle of Equal Pay for Work of Equal Value. Closing the Gender Pay Gap in Iceland. "So close, yet so far"

The enunciation of the principle of equality and non-discrimination is of fundamental source in international human rights laws and EU-law and has a prominent place in the Icelandic constitution. The principles of equality and non-discrimination are based on various legal concepts that have evolved mainly in international and regional human rights or equality jurisprudence. International legal pro

24 Night shift work and epigenetic modifications: miRNA relative expression levels among a European cohort of night shift workers

Objective To date, the major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors and are estimated to control more than 30 candidate miRNAs among night shift workers.Materials and Methods RNA was extracted from plasma samples of 110 night and 90day shift worker

Creation and validation of improved MALDI-TOF MS libraries for S. bovis-S. equinus-complex subspecies identification adapted to diagnostic culturing and extraction conditions

Objectives: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) libraries have limited capabilities for identification of Streptococcus bovis/Streptococcus equinus-complex (SBSEC) subspecies. The objective was to develop and validate novel MALDI-TOF MS libraries adapted to diagnostic culturing and sampling conditions for improved identification of SBSEC subs

A Reconstituted Capsid-Nucleus Platform Uncovers Distinct Roles of UL25 and UL36 in Herpesvirus Capsid Docking

Herpes simplex virus type 1 (HSV-1) delivers its genome into the host nucleus via docking of the viral capsid at the nuclear pore complex (NPC), a process mediated by the capsid vertex-specific complex (CVSC), composed of UL17, UL25, and UL36. While prior in vivo studies have implicated UL25 and UL36 in NPC interactions, their interpretation is complicated by indirect effects from viral traffickin

Reversible excited state electron transfer in an acceptor-acceptor hetero dyad

In this manuscript, we create a new hetero dyad consisting of two electron acceptors with nearly isoenergetic HOMO and LUMO levels, namely perylene diimide (PDI) and aza dioxa triangulenium (ADOTA). This dyad system displays an unusual and reversible excited state electron transfer process. Upon excitation, the dyad shows complete energy transfer from the locally excited PDI to the ADOTA moiety in

Precision nutrition for cardiometabolic diseases

Precision nutrition is a vibrant and rapidly evolving field of scientific research and innovation with the potential to deliver health, societal and economic benefits by improving healthcare delivery and policies. Advances in deep phenotyping technologies, digital tools and artificial intelligence have made possible early proof-of-concept research that expands the understanding of within- and betw

Youth

Youth are one of the nine major groups of civil society for sustainable development formalized by Agenda 21. The Major Group of Children and Youth is an active independent mechanism facilitating youth involvement in the United Nations system. Youth representatives from various organizations increasingly engage in global sustainability politics but face challenges such as financial constraints, tok

Childhood exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiometabolic indicators in childhood and adolescence : findings from a cohort study in rural Bangladesh

Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with cardiovascular diseases in adulthood, but studies examining childhood origins are scarce. Objective: To examine associations of childhood PAH exposure with cardiometabolic risk indicators in childhood and adolescence along with differences by sex. Methods: Urinary PAH metabolites [Σ1,2,3-hydroxyphenanthrene (Σ

Observation of Genuine High-dimensional Multi-partite Non-locality in Entangled Photon States

Quantum information science has leaped forward with the exploration of high-dimensional quantum systems, offering greater potential than traditional qubits in quantum communication and quantum computing. To advance the field of high-dimensional quantum technology, a significant effort is underway to progressively enhance the entanglement dimension between two particles. An alternative effective st

Arts on prescription intervention for primary healthcare patients with poor mental health or social isolation : a mixed-method study

Background: Primary healthcare providers are increasingly challenged in supporting patients with psychosocial needs. Arts on Prescription (AoP) has been shown to improve primary healthcare patients’ mental health wellbeing. The aim of the current study is to understand the psychosocial effect of participating in an Arts on Prescription programme. Methods: A total of 112 primary healthcare patients

Delivery of Ulva rigida extract by bicontinuous cubic lipid nanoplatforms for potential photodynamic therapy against pancreatic cancer

Ulva rigida is a widely available marine algae representing a valuable biomass from which natural photosensitizers (chlorophylls) can be obtained in an environmentally friendly manner using a green microwave-assisted extraction technique. If properly loaded in biocompatible nanoformulations, such highly hydrophobic chlorophylls with photosensitizing activity may constitute effective drugs useful i

Essential Concepts for Implementing the Sustainable Development Goals : An Introduction

This A-Z Guide offers an accessible and user-friendly overview of the essential concepts and terms needed to understand the implementation of the SDGs. Crafted in the form of an encyclopaedia, the volume presents 105 entries on important concepts and terms and their links to academic and policy debates. Each entry offers basic definitions of the concept or term at issue, followed by a brief discus

Belimumab concentrations and immunogenicity in relation to drug effectiveness and safety in SLE within a Swedish real-world setting

Objectives: Studies supporting therapeutic drug monitoring to biopharmaceuticals in SLE are scarce. We aimed to assess anti-drug antibody (ADA) occurrence in belimumab-treated SLE patients and associations between belimumab concentrations and clinical response, serological outcomes and adverse events. Methods. We included 100 patients treated with intravenous belimumab. Clinical data and biologica