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Studying how single nucleotide polymorphisms (SNPs) crosstalk with non-autologous factors to cause complex autoimmune diseases is challenging. An amino acid replacement in the neutrophil cytosolic factor 1 (NCF1-339/NCF1R90H) leading to lower reactive oxygen species induction has been reported as the major SNP for systemic lupus erythematosus (SLE). Here we show that infection with the murine noro

A ferrous complex bearing tris(carbene)borate ligands with imidazol-2-ylidene donors has been characterized by experimental and computational methods. Despite the pronounced destabilization of metal centered states by the exceptionally σ-donating ligand, the high-energy 3MLCT state of [Fe(ii)(phtmeimb)2] is rapidly deactivated by the barrierless conversion to the 3MC state.

Objective: Professional operatic singing is vocally demanding, making the maintenance of professional vocal health a paramount concern for the opera chorister. Occupational environment has been shown to affect vocal health for other vocally dependent professions. Hence, the objective of the current study was to explore what occupational environment factors affect the professional vocal health of S

HIV drug resistance (HIVDR) presents a significant challenge to antiretroviral therapy (ART) success, particularly in resource-limited settings like Ethiopia. This cross-sectional study investigated viral suppression rates and resistance patterns among patients on second-line ART across 28 Ethiopian health facilities. Blood samples collected from 586 participants were analyzed to measure CD4 count

It is elucidated how crystallization can be used to create lateral surface nanostructures in a size regime toward sub-10 nm using molecular self-assembly of short chain crystallizable block copolymers (BCP) and assist in overcoming the high-χ barrier for microphase separation. In this work, an amphiphilic double-crystalline polyethylene-b-polyethylene oxide (PE-b-PEO) block co-oligomer is used. A

Superconductor-semiconductor hybrid systems play a crucial role in realizing nanoscale quantum devices, including hybrid qubits, Majorana bound states, and Kitaev chains. For such hybrid devices, subgap states play a prominent role in their operation. In this paper, we study these subgap states via Coulomb and tunneling spectroscopy through a superconducting island defined in a semiconductor nanow

Bivalves are considered mainly filter-feeding organisms; they remove suspended particles including phytoplankton, zooplankton, and bacteria from the water column. Moreover, some bivalves can also feed via pedal-feeding, which is the uptake of organic matter from the sediment using cilia on the foot. Diplodon parallelopipedon is a native bivalve from South America, which can obtain their foo

In this work, four dyes—consisting of heteroleptic iron N-heterocyclic carbene (NHC) complexes—were investigated in dye-sensitized solar cell (DSC) applications to explore their behavior and interactions with the overall cell. Three of the four dyes contained amino-based electron donor moieties, while one was without this type of structure, and instead had only a hydrogen atom. Compared to earlier

Objective: Osteoarthritis (OA) is a common degenerative disease with a genetic contribution. However, no large nationwide family study concerning the heredity of OA has been published. This first nationwide study aimed to determine the familial risks of the main types of OA in twins, full-siblings, half-siblings, and cousins in Sweden. Design: The Swedish Multigeneration register was linked to the

AIM: Factors associated with unexpected absence or presence of coronary atherosclerosis in individuals at high/low estimated cardiovascular (CV) risk are largely unexplored. We assessed two extreme phenotypes: 1) no coronary atherosclerosis despite very high CV risk; and 2) severe-extensive coronary atherosclerosis despite low CV risk.METHODS: A multicenter, cross-sectional nationwide, population-

Objective Exposure to hexavalent chromium (Cr(VI)) occurs during several occupational activities and leads to lung cancer. Growing evidence suggests that microRNA (miRNA) plays an important part in carcinogenesis. This study was to explore circulating miRNAs of Cr(VI) exposed workers and to identify the potential biological function of differentially expressed miRNA (DEM).Material and Methods This

Parents of children with disabilities may face higher labor-market penalties given the extra care and support required. Using Swedish administrative data, we focus on first-born children with Cerebral Palsy (CP) to estimate impacts on parental labor-market outcomes. We apply an event study approach to identify effects up to 10 years after the birth of the child. Our results show that employment an

Background: Many people ageing with late effects of polio (LEoP) experience new or increased impairments which could negatively influence daily life. Currently, there is limited knowledge how LEoP-related impairments change over time. Objectives: To assess how various self-reported impairments change over 10 years among people with LEoP, and explore factors associated with the changes. Methods: Th

An Fe(III)-NHC complex has been employed for the green light driven catalysis of base-promoted homolytic aromatic substitution (BHAS) reactions. Tributylamine was used as a sacrificial electron donor, together with potassium carbonate as base in dimethyl sulfoxide as solvent. In contrast to previously studied photocatalysts, the excited Fe(III)-NHC complex is not reducing the arylhalide substrates

Majorana modes can be engineered in arrays where quantum dots (QDs) are coupled via grounded superconductors, effectively realizing an artificial Kitaev chain. Minimal Kitaev chains, composed by two QDs, can host fully localized Majorana modes at discrete points in parameter space, known as Majorana sweet spots. Unlike grounded superconductors, where the superconducting phase is a conserved quantu

To contribute to the development of effective support for early career researchers during and after doctoral education, the aim of this study was to examine the experiences of the early career transition after affiliation with an interdisciplinary graduate school, using the Swedish National Graduate School on Ageing and Health (SWEAH) as an example. Through qualitative interviews with 18 alumni, t

Particle exchange heat engines are a novel class of cyclic heat engines that are all-electrical, contain no moving parts and can therefore be scaled down to nanometer size. At the center of their operation is the manipulation of a particle flow between a hot and a cold reservoir through energy filtering mechanisms, where their efficiency depends primarily on the sharpness of the energy filter. In

Background & aims: Colorectal cancer (CRC), particularly rectal cancer, often requires neoadjuvant radiotherapy (RT) as part of its treatment plan. Although effective, RT can cause significant gastrointestinal side effects. Because the onset of RT-induced tissue injury can be anticipated, there is an opportunity to apply preventive measures before the damage occurs. This study aimed to assess

Background: Unhealthy lifestyle behaviours, including unhealthy alcohol consumption, physical inactivity, smoking, and nonadherence to dietary recommendations, are major contributors to non-communicable diseases and mortality. While adopting healthy behaviours can reduce these risks in middle-aged adults, research is limited. Therefore, the aim of this study was to assess the distribution of unhea