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An integrated framework is introduced and applied to assess the health impact of airborne pollution with greater physiological relevance, moving beyond conventional exposure metrics. Measured particle number size distribution data was integrated with a regional respiratory tract deposition fractions to estimate total and alveolar deposited particle surface area concentrations. Land use regression

microRNAs (miRNAs) are 20-24 nucleotides small, single-stranded, non-coding RNAs. They associate with Argonaute (AGO) proteins and exert their function by inhibition or degradation of messenger RNAs. A single miRNA can target hundreds of genes and one gene can be targeted by several miRNAs, hereby giving rise to a complex post-transcriptional network. In the brain, hundreds of miRNAs are expressed

The hematopoietic system is responsible for transporting oxygen and nutrients, fighting infections, and repairing tissue damage. Hematopoietic system dysfunction therefore causes a range of serious health consequences. Lifelong hematopoiesis is maintained by repopulating multipotent hematopoietic stem cells (HSCs) that replenish shorter-lived, mature blood cell types. A prokaryotic mechanism of im

Background:In Lynch syndrome, inherited mismatch repair (MMR) defects predispose to colorectal cancer and to a wide spectrum of extra-colorectal tumours. Utilising a cohort study design, we aimed to determine the risk of extra-colorectal cancer and to identify yet unrecognised tumour types.Methods:Data from 1624 Lynch syndrome mutation carriers in the Danish hereditary non-polyposis colorectal can

Combining multiple III-V materials into axial nanowire heterostructures has enabled the fabrication of custom nanowire-based devices useful for a wide range of applications. However, our ability to form axial heterostructures between arbitrary combinations of III-V compounds is impeded by a lack of information on the dynamics of the heterojunction formation process, often resulting in suboptimal h

RNA modifying enzymes play a pivotal role in reshaping gene expression programs in response to diverse intracellular and extracellular cues, thereby maintaining cellular homeostasis. When dysregulated, these enzymes are increasingly implicated in the onset and progression of various diseases. While traditionally recognised for their catalytic functions, mounting evidence suggests that many RNA mod

We investigated the exciton transfer dynamics in photosynthetic light-harvesting complex 2 (LH2) coupled to an optical microcavity. Using computational simulations based on Redfield theory, we analyzed how microcavity coupling influences energy relaxation and transfer within and between LH2 aggregates. Our results show that the exciton transfer rate between B850 rings follows a square dependence o

Inom läkemedelssektorn, originalföretagen som investerar stora summor pengar i forskning och utveckling av nya läkemedel vanligtvis söker patent för flera skyddsområden. De försöker utnyttja det monopol ett patent ger för att skydda sina egna originalläkemedel mot generiska läkemedels marknadsinträde och utebliven vinst som det för med sig. Generiska företag för att kunna lansera sina generiska prIn the pharmaceutical sector, originator companies that invest large sum of money in R&D of new medicines usually file patent applications for several areas of protection. They try to take advantage of a monopoly that a patent grants to protect their medicines against generic entry on the market and consequently the loss of profits. Generic companies in order to be able to launch their generic

I denna uppsats utreds och analyseras hur rättsväsendet hanterar hatbrott begångna på internet. År 2013 rapporterade Brottsförebyggande rådet att personuppklarningen vad gäller hatbrott begångna på internet är mycket låg. Följaktligen fortsätter uppsatsen med att identifiera orsakerna till den låga personuppklarningen samt de brister rättsväsendet besitter på området. I avslutande del av uppsatsenThis paper is set out to investigate and analyze how the judicial system handles hate crime committed on the internet. In 2013 the Swedish national council of crime prevention (Brå) reported that the clearance rate in terms of hate crime committed on the internet is very low. Hence the paper continues with identifying the causes of the low clearance rate and the shortcomings the judicial system po

Införande av en klimatskatt på nötkött i Sveriges påverkan på förekomsten av kolorektalcancer Man har i flertalet studier påvisat att konsumtion av rött kött och processat kött (däribland nötkött) skulle kunna ha en negativ inverkan på människors hälsa. Framförallt visar studier på kopplingar mellan konsumtion av rött och processat och en ökad risk för kolorektalcancer. Vidare visar studier att pConsumption of red and processed meat has been found to effect human health and especially the occurrence of colorectal cancer. At the same time cattle farming and production of beef have been shown to severely effect the environment and particularly the climate. Taxation of beef could be an instrument to decrease the greenhouse gas emissions from the production of beef, but due to high transition

Titel: Hur verkligt är verkligt värde? En studie om underprissättning vid börsintroduktioner Seminariedatum: 2 juni 2023 Kurs: FEKH69 – Examensarbete i redovisning på kandidatnivå Författare: Oskar Brunnéd, Simon Sandström, Jamal Shamma Handledare: Liesel Klemcke Syfte: Studien syftar till att undersöka ifall underprissättningen vid börsintroduktioner på Stockholmsbörsen och Nordic Growth Ma

I dagens samhälle är en stor del av industrin beroende av kemiska reaktioner. Hastigheter för kemiska reaktioner kan påskyndas med hjälp av katalysatorer. Heterogena katalysatorer, alltså katalysatorer av fast karaktär, består av ett bärarmaterial på vilket det aktiva katalyserande ämnet är applicerat. På företaget Hulteberg Chemistry & Engineering AB används pulver som katalysatorbärare till Heterogenous catalysts consist of a large surface area support material applied with the catalytic active phase, and the activity of a catalyst is often correlated to the surface area per volume. Support materials often need to be processed further to be optimal for specific processes. For example, powders can be suitable for minireactors or fluidized-bed reactors. However, in a fixed-bed reactor,

This meta-analysis and systematic review examined the effects of psychedelic substances on death anxiety, specifically evaluating whether psychedelic experiences are associated with statistically significant reductions in death anxiety. Studies were eligible if they quantitatively assessed death anxiety or death acceptance using validated measures, or qualitatively explored attitudes toward death

BACKGROUND: Multidrug resistant Acinetobacter baumannii remains a global concern with its ability to adhere, disperse and sustain in areas involving suboptimal infection control measures, particularly in war areas. In this study we aimed to evaluate the susceptibility profiles, molecular epidemiology and pathogenesis of A. baumannii isolates from conflict zones in Ukraine.METHODS: A. baumannii wou

Ultrasmooth solution-processable quasi-2D perovskite thin films are of critical importance for many optoelectronic devices. In this work, we fabricated an ultrasmooth intermediate-phase free quasi-2D (PEA)2(FA)n−1PbnBr3n+1 perovskite film by using antisolvents with different polarities and boiling points to engineer the crystallization process. The XRD patterns of the perovskite powder showed that

The construction of heterojunctions between catalysts and cocatalysts is a widely recognized strategy to enhance catalytic activity. The precise placement of cocatalysts is widely understood to optimize charge transfer pathways and catalytic active sites. In this study, we demonstrate that site-selective decoration on an anisotropic catalyst, achieved by modulating solvent polarity and precursor r

The new ACR/EULAR classification criteria for APS differ from the previous Sydney criteria by incorporating a broader range of clinical manifestations beyond venous/arterial thromboembolism and obstetric complications. These include microvascular disease, heart valve disease and thrombocytopenia. We applied both classification systems to a cohort of 139 individuals diagnosed with primary APS in So