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Background: Platelet activation and thrombus formation play critical roles in the pathogenesis of myocardial infarction (MI). In addition to their role in energy production, platelet mitochondria also regulate cellular functions related to apoptosis, oxidative stress, and inflammation. Epigenetic modifications of platelet mitochondrial DNA (mtDNA) may influence platelet function and are believed t
Diffusion-weighted magnetic resonance imaging (DW-MRI) aims to disentangle multiple biological signal sources in each imaging voxel, enabling the computation of innovative maps of tissue microstructure. DW-MRI model development has been dominated by brain applications. More recently, advanced methods with high fidelity to histology are gaining momentum in other contexts, for example, in oncologica
Online Raman scattering and in situ extinction measurement were combined in this work for qualitative and quantitative evaluations of various soot in the aerosol phase with different organic compounds.
Proximity testing is at the core of several Location-Based Services (LBS). Despite a series of reported and confirmed abuses, modern LBSs still demand their clients to disclose their locations in plain in order to preform location proximity testing. This works aims at enhancing proximity testing with privacy. We design CatNap a novel protocol that (1) implements precise Euclidean distance matching
Aims Gene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary validation that may make use of cell line slides mimicking cytological samples. In this international multi-institutional study, gene fusion reference standards were developed and validated. Methods Cell lines harbouring EML4(13)–ALK(20) and SL
Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are
Most countries in Sub-Saharan Africa have made great strides towards more accessible and higher quality schooling and medical systems in recent years. Despite this, education and health care in Africa lag behind other developing regions and large inequalities in educational levels and health care access remain across countries, subnational regions, and gender. Cameroon, in west-central Africa, wit
Introduction: Antibiotics for acute uncomplicated diverticulitis (AUD) have been questioned in several studies. Thus, it is of value to identify risk factors for recurrence and complications to identify the best strategy for treatment. The aim was to investigate risk factors for recurrence and complications within at least 1 year after hospitalization for AUD. Methods: This is a retrospective stud
Persistence of dissolved organic matter (DOM) in aquatic environments may in part be explained by high diversity and low concentrations of carbon substrates. However, changes in dissolved substrate quality can modify aquatic bacterial community composition and rate of carbon uptake. The aim of this study was to test if the presence of multiple simple substrates affects the turnover of organic carb
The agricultural sector has a critical role in creating social and environmental value of natural resources in addition to its traditional role of creating economic value by supplying food to the ever-increasing world population. In fulfilling this dual role, the agricultural sector often faces competing pressures: to operate financially profitable businesses and to create, maintain, and benefit f
A structured approach to derive the water activity function of cellulose-based materials which describe the sorption behavior from dry fiber up to the fiber saturation point is proposed. The coupling between the sorption isotherm and the net isosteric heat of sorption is incorporated in a consistent way, which allows for coupled heat-diffusion problems to be solved. Three different models are deri
Radio for everyone? Passages in English and other languages in Swedish publicservice radioThis article focuses on Swedish public service radio (Sveriges Radio, SR) and howinterviews in languages other than Swedish are given in SR. In the article, the result of a close analysis of 42 hours of broadcasting from SR is presented. All in all, a dozen languages are identified; however, English clearly d
Research has shown that many new parents experience taboo obsessions, which can lead to increased anxiety, depression, negative impact on parental function and quality of life. Many parents do not seek help due to shame or stigma. This cross-sectional survey study with self-recruited parents of infants and toddlers in Sweden explored: 1) the frequency and 2) impact of taboo obsessions, 3) whether
Rainfall is a primary factor for agricultural production, especially in a rainfed agricultural region. Its accurate prediction is therefore vital for planning and managing farmers’ plantations. Rainfall plays an important role in the symmetry of the water cycle, and many hydrological models use rainfall as one of their components. This paper aimed to investigate the applicability of six machine le
The FDI World Dental Federation suggests that "dentistry, as a profession, should integrate Sustainable Development Goals into daily practice and support a shift to a green economy in the pursuit of healthy lives and wellbeing for all, through all stages of life." This article reports on the recent activity of the Association for Dental Education in Europe Special Interest Group for Sustainability
BACKGROUND: Research on health systems resilience has focused primarily on the theoretical development of the concept and its dimensions. There is an identified knowledge gap in the research on how to build resilience in health systems in practice and 'what works' in different contexts. The aim of this study is to identify practical strategies for building resilient health systems from the empiric
A radioactive fallout following a nuclear accident can result in contamination of large areas of land. In order to protect human health against ionizing radiation, large-scale decontamination that includes multiple sets of clean-up measures may be necessary. Sweden lacks national experience of this type of large-scale decontamination. There are thus great uncertainties in the effect of such a deco
The panel initiates a discussion on the role of information behaviour research in addressing majorchallenges facing our society. These include climate change, political extremism, and health threats –in many of which information plays a crucial role. The panel asks, first, what is the role andresponsibility of information behaviour research in addressing societal challenges, and second, is therea
