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Design science research involves creating and evaluating innovative methods and approaches to be used in design practice. We present an approach to be used in the process of designing Management Support Systems (MSS). The nature of managerial work makes the design, development, and implementation of MSS a major challenge. The MSS literature suggests that determining MSS requirements and specificat

Differences in national legislations can affect the international competitiveness of an industry. For example, stringent EU regulations on animal welfare and environmental protection are often said to be a cost disadvantage for EU producers competing on the global market. However, in recent years, powerful retailers and food processors have started to impose requirements on downstream producers th

High-speed laser diagnostics was utilized for single-cycle resolved studies of the fuel distribution in the combustion chamber of a truck-size HCCI engine. A multi-YAG laser system consisting of four individual Nd:YAG lasers was used for planar laser-induced fluorescence (PLIF) imaging of the fuel distribution. The fundamental beam from the lasers at 1064 nm was frequency quadrupled in order to ob

The Modelica language, targeted at modeling of complex physical systems, has gained increased attention during the last decade. Modelica is about to establish itself as a de facto standard in the modeling community with strong support both within academia and industry. While there are several tools, both commercial and free, supporting simulation of Modelica models few efforts have been made in th

In the drying section of a paper machine, steam heated cylinders are used to control the moisture of the produced paper. In previous work it has been shown that the dynamics from the steam valve to the steam pressure in the cylinder can be described by a linear second order black box process model. In this paper an equivalent model based on first principles is presented. The foundation of this mod

With the advent of nationwide mammography screening programmes, a number of natural history models of breast cancers have been developed and used to assess the effects of screening. The first half of this article provides an overview of a class of these models and describes how they can be used to study latent processes of tumour progression from observational data. The second half of the article

Lunds kommun äger LKF, Lunds Kommuns Fastighets AB. LKF i sin tur äger och förvaltar ett stort fastighetskapital. Marknadsvärdet uppskattas till omkring 16 000 miljoner kronor för närvarande. En central fråga infinner sig: förvaltas detta kapital på ett effektivt sätt? Ger den nuvarande förvaltningen en gynnsam avkastning åt medborgarna i Lunds kommun? För att finna ett svar på denna fråga har Lun

Objectives: To investigate factors associated with multiple induced abortions. Materials and methods: A multi-centre cross-sectional survey among abortion-seeking women (n = 623;14-47y) in Sweden, 2021. ‘Multiple abortions’ was defined as having had ≥2 induced abortions. This group was compared to women with a previous experience of 0-1 induced abortion. Regression analysis was conducted to determ

The pathophysiological mechanisms intersecting metabolic and neurodegenerative disorders include insulin resistance, which has a strong involvement of environmental factors. Besides central regulation of whole-body homeostasis, insulin in the central nervous system controls molecular signalling that is critical for cognitive performance, namely signalling through pathways that modulate synaptic tr

Background: Coarctation of the aorta (CoA), a congenital narrowing of the proximal descending thoracic aorta, is a relatively common form of congenital heart disease. Untreated significant CoA has a major impact on morbidity and mortality. In the past 3 decades, transcatheter intervention (TCI) for CoA has evolved as an alternative to surgery. Objectives: The authors report on all TCIs for CoA per

Aims/hypothesis: Individuals with diabetes can be clustered into five subtypes using up to six routinely measured clinical variables. We hypothesised that circulating protein levels might be used to distinguish between these subtypes. We recently used five of these six variables to categorise 7017 participants from the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial into the

Biomolecules preserved in deep time have potential to shed light on major evolutionary questions, driving the search for new and more rigorous methods to detect them. Despite the increasing body of evidence from a wide variety of new, high resolution/high sensitivity analytical techniques, this research is commonly met with skepticism, as the long standing dogma persists that such preservation in