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From biomonitoring studies to lowered occupational exposure limits for hexavalent chromium

Occupational exposure to the carcinogen hexavalent chromium [Cr(VI)] occurs during stainless steel production, welding, and chrome plating. Two sister-projects, SafeChrom and SAM-Krom, were initiated in Sweden and Denmark, respectively, to inform stakeholders, decision-makers and regulators on current occupational exposure to Cr(VI), and preventive measures prior to revision of national occupation

Guiding Light to Detect Life: Nanowires for Optical Biosensing

Semiconductor nanowires provide a versatile platform for fluorescence-based detection enabled by their high refractive index and waveguiding properties, which amplify excitation and emission from surface-bound fluorophores. Together with their large surface-to-volume ratio, these features enable enhanced and even single-molecule sensitivity.This thesis explores the use of gallium phosphide (GaP) a

Interfaces in Epitaxially Grown Zn3P2 Nanowires and Their Composition-Dependent Optoelectronic Properties for Photovoltaic Applications

Epitaxially grown nanowires have shown promise for photovoltaic applications due to their nanophotonic properties. Moreover, the mechanical properties of nanowires can reduce crystallographic defect formation at interfaces to help enable new material combinations for photovoltaics. One material that stands to benefit from the nanowire morphology is zinc phosphide (Zn3P2), which, despite promising

Long-Term Outcome of Percutaneous Coronary Intervention Using Absorb Bioresorbable Scaffold : A SCAAR Study

Background: Bioresorbable scaffolds have been associated with inferior outcomes compared to contemporary permanent metallic drug-eluting stents (DES) for percutaneous coronary intervention, particularly within the initial years after implantation; however, their long-term performance remains uncertain. This study aimed to evaluate the long-term outcomes of Swedish patients treated with Absorb bior

Manipulating Thermoacoustic Streaming : Measuring the Synergy of Laser-induced Temperature Gradients and Ultrasonic Pressure Fields in Acoustofluidic Microchannels

In Acoustofluidics, sound pressure waves can cause a force field on the liquid in a microfluidic channel. The forces depend on density and compressibility of the medium as well as the pressure and velocity amplitude of the sound. The forces lead to a steady flow in the bulk of the fluid, namely acoustic streaming. If a localized change in temperature introduces a gradient in compressibility and de

Non-cell-autonomous control of mouse gastruloid development by the ultra-conserved lncRNA T-UCstem1

The role of long non-coding RNAs (lncRNAs) in early mammalian embryogenesis remains unclear due to the complexity of the regulatory mechanisms involving lncRNAs and the limited availability of embryo samples. Stem cell-based models, such as mouse gastruloids, provide new ways to address these challenges. Here, we investigate the function of ultra-conserved lncRNA T-UCstem1 in mammalian body plan f

Medial plica is associated with progression of medial meniscus extrusion in middle-aged persons with Kellgren–Lawrence grade 0 : data from the osteoarthritis initiative

Background: Medial plica is a structure with limited understanding of its pathology, but it may be related to the development of medial knee osteoarthritis (OA). We examined the association between medial plica and medial meniscus extrusion (MME), progression of MME, and the risk of early-stage knee OA development in middle-aged persons. Methods: A total of 340 subjects with tibiofemoral Kellgren–

Emergent heat highways in the Weyl semimetal NdAlSi

Magnetic Weyl semimetals have emerged as a fertile ground for exploring quantum phases of matter and quasiparticles. The latter includes unconventional fermions with larger Chern numbers than those of conventional Weyl fermions and topologically nontrivial band structures in bosonic excitations. They hold potential for further experimental exploration of emergent quantum matter, magnon-polarons, w

Verbal memory in major depressive disorder in a long-term perspective : a five-year longitudinal study of first episode patients

Introduction: Major depressive disorder (MDD) is associated with cognitive impairment, including verbal memory. Limited knowledge exists following memory performance in first episode (FE) MDD. This study investigated verbal memory, depressive symptoms, and relapse in FE MDD over five years, from the trait, state, and scar perspectives. These perspectives suggests that deficits in memory either pre

Prevalence and common cardiovascular risk factors in aortic valve calcification in the middle-aged general population

Aims Aortic valve calcification (AVC) is an underlying pathophysiological mechanism for aortic stenosis that is common in the elderly, but less is known in younger individuals. The aim was to study the prevalence and associated characteristics of AVC in a middle-aged general population. Methods and results Data were obtained from the Swedish CArdioPulmonary bioImage Study (SCAPIS) comprising 30 15

Interdisciplinary risks–a delicate balance between trust and critical review

We argue that the subject matter and objectives of risk science establish it as an inherently interdisciplinary field, closely connected to both academic disciplines and practical applications. However, risk research faces a range of interdisciplinary challenges. These include the production of low-quality research—characterised by superficial and insufficiently grounded conclusions—a lack of mutu

Immune biomarkers for epilepsy in autism : indications of cytokine alterations in an exploratory cross-sectional pediatric study

BACKGROUND: Children with autism spectrum disorder (ASD) are at increased risk of epilepsy (EP), but distinguishing epileptic seizures from ASD-associated behavior remains a clinical challenge. Although previous studies have reported changes in peripheral immune markers in adults with EP, it remains unclear whether similar immune signatures are present in pediatric patients with both ASD and EP, a

Microalgae for the Extraction and Separation of Rare Earths : An STXM Study of Ce, Gd, and P

Rare earth elements (lanthanides) are critical materials for many applications, particularly those involved in new energy. Extracting these elements economically from low-concentration sources may be challenging. This study investigates the interaction of Ce and Gd with microalgae that have been triggered to form phosphate-rich granules. Lanthanides usually occur in nature as phosphates, and there

Phosphorus Storage in Microalgae : STXM and XAS P K-Edge Investigation

When exposed to high levels of phosphate after experiencing phosphate deficiency, microalgae can synthesize granules rich in intracellular phosphate. The understanding of the mechanism of production and nature of these granules remains incomplete. Here we studied phosphate distribution and chemistry in Chlamydomonas reinhardtii and Desmodesmus armatus using scanning transmission X-ray microscopy (

The Advanced Therapies model of Lund an integrated approach to accelerate access for many patients

Scientific breakthroughs in the field of cell and gene therapy lay the groundwork for therapeutic innovation, but their translation and integration into routine care is delayed by systemic inefficiencies and limited cross-sector alignment. The Advanced Therapies model of Lund is a proactive and integrated approach designed to accelerate the development of advanced therapies from discovery to reimb

The Cuneiform Digital Library Initiative (CDLI) : A free database of all cuneiform texts

Since its inception in 1998, the Cuneiform Digital Library Initiative (https://cdli.earth) has become the global authority index for inscribed artifacts of the cuneiform world, providing an essential reference for a corpus of half a million historical documents that form an important part of the world’s written heritage. The CDLI infrastructure is now foundational to the study of the history of th

Depressive symptoms in people with late effects of polio and the association with sociodemographic and disability-related factors

Background: Late effects of polio (LEoP) is a progressive condition leading to a lifelong disability that can affect mental health. There is limited knowledge of depressive symptoms and associated factors in people with LEoP. Objective: To assess the occurrence of depressive symptoms in people with LEoP and explore the association with sociodemographic and disability-related factors. Design: Cross