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Purpose: Abdominal wall complications can be reduced by adhering to guidelines for midline laparotomy closure. However, implementation of guidelines can be challenging. To address this issue, a laparotomy closure device for swift and standardized abdominal closure was developed. The study evaluated the quality of the suture, safety, and speed of the device in a clinical setting. Methods: A prospec
In this paper we show that OpenAI’s Large Language Model (LLM) GPT perform remarkably well when used for title and abstract eligibility screening of scientific articles and within a (systematic) literature review workflow. We evaluated GPT on screening data from a systematic review study on electric vehicle charging infrastructure demand with almost 12,000 records using the same eligibility criter
Global policies, legislation, and eco-friendly initiatives have induced the steel industry to integrate sustainable development approaches. Sustainability requires all phases from raw material sourcing to transportation to waste and carbon footprint elimination—yielding positive effects. This research employs a two-step approach in sustainability. The first phase entails conducting a systematic li
Background Suicide attempts are common in youth and have potentially lethal outcomes. Effective treatments targeting suicide attempts are scarce. Objective To assess the feasibility and preliminary efficacy of a family-based cognitive behavioural treatment relative to an active control for youth with suicidal behaviour. Methods 30 youths (93% female; mean (SD) age=14.6 (1.5) years) residing in Swe
Abstract Herein we report on the decarboxylative alkenylation between alkyl carboxylic acids and enol triflates. The reaction is mediated by a dual catalytic nickel and iridium system, operating under visible light irradiation. Two competing catalytic pathways, from the excited state iridium photocatalyst, are identified. One is energy transfer from the excited state, resulting in formation of an
Key questions for understanding hippocampal function in memory and navigation in humans are the type and source of visual information that reaches the human hippocampus. We measured bidirectional pairwise effective connectivity with functional magnetic resonance imaging between 360 cortical regions while 956 Human Connectome Project participants viewed scenes, faces, tools, or body parts. We devel
INTRODUCTION: We evaluated differences in p-tau levels between Alzheimer's disease (AD), a condition with brain-specific changes in p-tau, and amyotrophic lateral sclerosis (ALS), a condition associated with increases in peripheral p-tau levels. METHODS: Cerebrospinal fluid and plasma from 668 participants were analyzed using immunoassays specific for the low-molecular-weight (LMW) tau isoforms pr
Despite the crucial role of various insulin analogs in achieving satisfactory glycemic control, a comprehensive understanding of their in-solution dynamic mechanisms still holds the potential to further optimize rapid insulin analogs, thus significantly improving the well-being of individuals with Type 1 Diabetes. Here, we employed hydrogen-deuterium exchange mass spectrometry to decipher the mole
För att främja ett aktivt och hälsosamt åldrande (AHA) är det avgörande att förstå hur olika generationer använder digitala teknologier, då dessa verktyg blir en alltmer integrerad del av vardagen. Detta avhandlingsprojekt undersökte teknikanvändning bland kvinnor och män i tre åldersgrupper som representerar olika generationer (30–39, 50–59 och 70–79 år), med fokus på attityder, användningsmönsteTo promote active and healthy ageing (AHA), it is essential to understand how different generations engage with digital technologies, as these tools are becoming increasingly integral to everyday life. This thesis project explored technology adoption among men and women from three age groups representing different generations (30–39, 50–59 and 70–79 years), focusing on attitudes, usage patterns, a
BACKGROUND: Omentectomy has traditionally been performed in gastric cancer surgery, but omental preservation has become increasingly common. It is unclear whether omentectomy leads to additional survival benefit compared with omental preservation. This nationwide population-based cohort study aimed to assess survival and surgical outcomes comparing omental preservation to omentectomy in curative-i
In mouse early pachytene spermatocytes, the X and Y chromosomes undergo rapid non-homologous (NH) synapsis and desynapsis, but the functional significance remains unknown. Here, we report that pachynema-specific knockout of Speedy A (SpdyA) from telomeres caused persistent Y-X NH synapsis, with the entire Y axis synapsed onto the X axis. This persistent Y-X NH synapsis did not interrupt meiotic se
Naturvetenskap, teknik, ingenjörsvetenskap och matematik, på engelska ofta grupperade under akronymen STEM, är traditionellt mansdominerade områden. Särskilt inom ingenjörsvetenskap och teknologi är kvinnor fortfarande kraftigt underrepresenterade. Bristen på kvinnor inom STEM innebär utmaningar i att möta arbetsmarknadens behov, för produktkvalitet på grund av brist på olika perspektiv i designprScience, technology, engineering and mathematics, often grouped under the acronym STEM, are traditionally male dominated fields. Especially in engineering and technology, women continue to be heavily underrepresented. The lack of women in STEM poses challenges for meeting the labor market demands, for product quality due to a lack of diverse perspectives in the design process, and for gender equal
How we teach is strongly influenced by the culture we teach in, especially what (we believe) our colleagues think is good and acceptable. Understanding the reluctance to changes in teaching practice, including fear of disapproval from colleagues and students, investigating and reappraising those fears, and starting to talk about alternative interpretations is a first step towards overcoming the in
A novel concept of cold neutron source employing chessboard or staircase assemblies of high-aspect-ratio rectangular para-hydrogen moderators with well-developed and practically fully illuminated surfaces of the individual moderators is proposed. An analytic approach for calculating the brightness of para-hydrogen moderators is introduced. Because the brightness gain originates from a near-surface
BACKGROUND: Low back pain (LBP) is a leading cause of work absence globally. Digital interventions have the potential to increase access to self-management support for individuals with persistent LBP.OBJECTIVE: This study aims to evaluate the feasibility, usability, and acceptability of a digital educational program (MyRelief) designed to support self-management strategies for people with persiste
Introduction: Most cervical cancer cases in Sweden are diagnosed among women who have failed to attend screening. The objective of this study was to analyze the effectiveness of offering vaginal HPV (human papillomavirus) self-samples to long-term non-attendees as a routine in this screening program, in which non-attendees had already been the targets of several interventions. Material and Methods
Anxiety disorders are common in children and adolescents, but access to evidence-based treatment is limited. Most clinical guidelines recommend stratified care, where less complex patients are offered low intensity interventions and complex patients more intensive options. Stepped care, where all patients initially receive low-intensity treatment, has gained traction due to its potential cost-effe
Gamified virtual reality (VR) environments are increasingly used to enhance engagement and learning, yet most designs still adopt a one-size-fits-all approach that overlooks motivational diversity. The HEXAD framework, which classifies users into six player types, provides a promising lens for addressing this gap, but its predictive validity in immersive VR remains contested. This study investigat
Recent studies provide insights about local agency in regional development. While acknowledging non-local actors and drivers, these studies have not systematically discussed the link between extra-regional relations and local agency. This paper first discusses three key arguments in the literature on extra-regional relations covering context-specific dependencies, strategic coupling and open innov
