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Aims/hypothesis: Sleep duration is a risk factor for incident diabetes mellitus and CHD. The primary aim of the present study was to investigate, in sex-specific analyses, the role of incident diabetes as the possible biological mechanism for the reported association between short/long sleep duration and incident CHD. Considering that diabetes is a major risk factor for CHD, we hypothesised that a

Pigment epithelium derived factor (PEDF), a ubiquitously expressed 50 kDa secreted glycoprotein, was recently discovered to regulate self-renewal of neural stem cells and have a supportive effect on human embryonic stem cell growth. Here, we analyzed expression of PEDF in the murine hematopoietic stem cell (HSC) compartments and found that PEDF is highly expressed in primary long-term HSCs. Theref

Objectives The aim was to investigate the variation in risk of breast cancer between occupational groups with a focus on white-collar and blue-collar workers and to investigate to what extent the differences were explained by risk factors related to reproduction and lifestyle. Methods Between 1991 and 1996, 14 119 women born between 1923 and 1950 and residents of Malmö, Sweden, were included in th

BACKGROUND: Analysis of circulating tumor cells (CTC) is a promising prognostic marker in castration-resistant prostate cancer (CRPC). The aim of this study was to investigate CTC detection and phenotyping as prognostic biomarkers for response to primary androgen deprivation therapy (ADT) of metastatic prostate cancer (PC). METHODS: PC patients presenting with a prostate specific antigen (PSA) >80

Deficient production of anti-viral interferons (IFNs) may be involved in causing viral-induced asthma exacerbations. Hence, drugs inducing lung IFN production would be warranted. Azithromycin may reduce asthma exacerbations but its modus operandi is unknown. Here, we investigated if azithromycin induces IFNβ expression in vitro in rhinovirus-infected bronchial epithelial cells from asthmatic donor

More than forty per cent of the mammalian genome is derived from retroelements, of which about one-quarter are endogenous retroviruses (ERVs). Some are still active, notably in mice the highly polymorphic early transposon (ETn)/MusD and intracisternal A-type particles (IAP). ERVs are transcriptionally silenced during early embryogenesis by histone and DNA methylation (and reviewed in ref. 7), alth

The transcription factor STAT3 is a potential target for the treatment of castration-resistant prostate cancer. Galiellalactone (1), a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes. In this study we characterized 6 (GPA512, Johansson, M.; Sterner, O. Patent WO 2015/132396 A1, 2015), a prodrug of 1. In vitro studies showed that 6 is rapidly converted to 1 in plasma

BACKGROUND—: Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals at greatest AF risk could minimize the incidence of cardioembolic stroke. METHODS—: To determine whether genetic data can stratify risk for development of AF, we examined associations between AF genetic risk scores and incident AF in five prospective studies comprising 18,919 individuals of Europea

Background Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. Objectives This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysi

Background: Current prostate cancer screening guidelines conflict with respect to the age at which to initiate screening. Objective: To evaluate the effect of prostate-specific antigen (PSA) screening versus zero screening, starting at age 50-54 yr, on prostate cancer mortality. Design, setting, and participants: This is a population-based cohort study comparing 3479 men aged 50 yr through 54 yr r

The present thesis investigated Swedish nouns differing in concreteness, specificity and emotional content using linguistic, psycholinguistic and neurolinguistic methods. The focus of Paper I was a semantic analysis of discourse produced by a person with a lesion in visual (left occipital) cortex. The results showed that the lesion site was related to with problems processing concrete nouns relateThe present thesis investigated Swedish nouns differing in concreteness, specificity and emotional content using linguistic, psycholinguistic and neurolinguistic methods. The focus of Paper I was a semantic analysis of discourse produced by a person with a lesion in visual (left occipital) cortex. The results showed that the lesion site was related to with problems processing concrete nouns relate

Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key ques

This paper presents a new automatic algorithmfor extracting properties of an individual artist’sstyle and applying those properties to other drawings.The algorithm can be used to ensure consistent artisticstyle across a project by automatically transferringa selected style to hand drawn images. We present analgorithm that uses multiple stages; subdivision of animage into selected geons, extraction

Ger pressar dig bra vibrationer? Idag är allt från kaffemaskiner och gräsklippare till krutpistoler och bilar uppkopplade och kan närsom-helst ge oss en statusrapport genom bara ett par klick i en app. Vi kan med mobilen kolla bilens bräns-lenivå, geografiska position eller om vi glömt att låsa på väg in från par-keringen. Så varför skulle inte statu-sen på utrustningen som används för att tillveIn a world where the concept of just-in-time has been lifted outside of the manu-facturing world and onto the market, the increasing demand of luxury wares like cars is accompanied only by tougher industrial conditions and no room for error. Loss of productivity and decrease in efficiency can be devastating to any manufac-turing company in today’s market climate. One of the largest causes of these

En aktieägare har inget personligt betalningsansvar för aktiebolagets förpliktelser. Bolagets borgenärer har således endast bolagsförmögenheten som säkerhet för sina fordringar på bolaget. På grund av detta är det viktigt att en sådan förmögenhet tillförs bolaget då det bildas och att denna förmögenhet sedan stannar kvar i bolaget under verksamhetens gång, detta för att skydda borgenärerna. Det ärA shareholder has no personal liability for the obligations of the limited company. The creditors of the company have only the company assets as a collateral for their claims against the company. Therefor, it is important that capital is contributed to the company when it is founded and that the capital stays in the company during the activity, and this to protect the creditors. Owing to this, ref

Bakgrund: Pes Equino Varus Adductus (PEVA), även känt som klumpfot, är en medfödd felställning i fotens leder som kräver omfattande behandling under flera år. Det finns ett fåtal studier om hur PEVA påverkar barns grovmotoriska utveckling. Mer kunskap behövs om vilka faktorer som eventuellt kan påverka den grovmotoriska utvecklingen. Syfte: Att beskriva och jämföra utveckling av grovmotorik och pa

With the foreign political turbulence after the fall of the Berlin Wall, the world came into a change. The post-cold war environment meant that the politics of the bipolarity no longer were the case. This period leads to pressure in redefining Sweden’s foreign and security policy, resulting in an emergence of a different commitment to the countries neutrality and non-alignment. In the light of Kje

Purpose: The purpose of this thesis is to examine if there are financial purposes for companies to create sustainability reports, by comparing the quality of sustainability reports with profitability for swedish public companies, listed on Nasdaq OMX Stockholm, that are subject to the 6 chapter 10 § Annual Accounts Act by the year of 2018, that earlier haven’t created a sustainability report. Me