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Melanoma remains the most aggressive form of skin cancer, characterized by high metastatic potential, genetic heterogeneity, and resistance to conventional therapies. The Melanoma MEGA-Study is a multi-center initiative designed to address these clinical challenges by integrating advanced proteogenomic profiling, clinical metadata, with AI-driven digital pathology and machine learning analytics, a

Bakgrund: God kommunikativ och empatisk förmåga hos läkare skapar trygghet och upplevs som professionellt av patienter och närstående. Forskning visar att empati förbättrar patienters följsamhet, nöjdhet och relationen mellan läkare och patient, vilket i sin tur leder till högre vårdkvalitet, bättre behandlingsresultat och minskade vårdkostnader. Ett empatiskt förhållningssätt främjar både fysisk

Background: Glioblastoma, IDH wildtype is the most common primary malignant brain tumor in adults. Despite best available treatment, prognosis remains poor. Current standard therapy consists of surgical tumor removal followed by radiotherapy and chemotherapy with the alkylating agent temozolomide. Antisecretory factor (AF), an endogenous protein, may potentiate the effect of temozolomide and allev

INTRODUCTION: As the world population is rapidly becoming older, the incidence of traumatic brain injury (TBI) is increasing among older adults with vast implications for brain health of older adults in Europe. Due to differences from younger patients, there are areas of uncertainty in the assessment, diagnosis and management of TBI in older adults.RESEARCH QUESTION: To reach a consensus among exp

Background: Bioresorbable scaffolds have been associated with inferior outcomes compared to contemporary permanent metallic drug-eluting stents (DES) for percutaneous coronary intervention, particularly within the initial years after implantation; however, their long-term performance remains uncertain. This study aimed to evaluate the long-term outcomes of Swedish patients treated with Absorb bior

Are there such things as moral, rights and an inner sense of justice? Do they origin from God or are they something given by nature? If there are such things, should they be a part of the legal system? This essay has drawn its inspiration from this kind of thoughts and how they have been handled through history. The structure of the essay is two-folded. Part one is a historical review of the eme

The Roma people’s isolation has been a major concern for the population in Europe for many years. Programs and legal frameworks are created for the protection for this underprivileged group; however the isolation continues to exist. The purpose of this paper is to explain why many of the measures taken are shown to be inadequate. The outlining and the examination of the history in this matter will

Preeclampsia (PE) is a serious pregnancy complication that manifests as hypertension and proteinuria after the 20(th) gestation week. Previously, fetal hemoglobin (HbF) has been identified as a plausible causative factor. Cell-free Hb and its degradation products are known to cause oxidative stress and tissue damage, typical of the PE placenta. A1M (α1-microglobulin) is an endogenous scavenger of

Background: Vietnam introduced the Health Care Fund for the Poor in 2002 to increase access to health care and reduce the financial burden of health expenditure faced by the poor and ethnic minorities. It is often argued that effects of financing reforms take a long time to materialize. This study evaluates the short-term impact of the program to determine if pro-poor financing programs can achiev

Moving towards an ecologically sound society requires strong support from higher educational institutions. During the past decade, the Journal of Cleaner Production has published more than 150 articles that have highlighted advances in academic efforts on sustainability in higher education, that were focused upon education, research, outreach and greening of campus operations in universities from

Background: Prostate-specific antigen (PSA) has modest specificity for prostate cancer. A panel of four kallikrein markers (total PSA, free PSA, intact PSA, and kallikrein-related peptidase 2) is a highly accurate predictor of biopsy outcome. The clinical significance of biopsy-detectable cancers in men classified as low-risk by this panel remains unclear. Methods: The Malmo Diet and Cancer study

A unified approach is presented for establishing exact integration of the constitutive equations in elastoplasticity, assuming the total strain-rate direction to be constant. This unified approach includes all previous exact integration procedures as special cases and, in addition, some new closed-form solutions are derived for combined kinematic and isotropic hardening. Special emphasis is laid o

Calcium phosphates have been of great interest in the field of medicine for many decades due to their biocompatibility, hardening properties and diverse areas of application. In this study two different alpha phase tricalcium phosphate powders were produced of distinctly different particle size distributions. These two powders were then tested for reactivity and phase evolution. X-ray diffraction

Objective Intrauterine growth restriction (IUGR) is a recognized risk factor for neurological deficits later in life. Abnormal fetal blood flow in the presence of IUGR helps to distinguish fetuses with true growth impairment from those that are small but normally grown. This study aimed to evaluate the influence of IUGR with abnormal fetal blood flow on cognitive function and psychological develop

Parts of Dunn's methodology in "Jesus Remembered" (2003) are scrutinised: the meaning of "memory" and whether this is the ultimately attainable object of historiography. I contend that historical research should not content itself with investigating how memories are "fictionalized", i.e. retained in narrative form, but press on to verified judgments on historical facts. "Grand (or: master) narrati

In this grounded theory study, the authors analyze interviews and participant observation data related to palliative cancer nursing in hospitals. Striving for Emotional Survival emerged as the pattern of behavior through which nurses deal with their main concern, the risk of being emotionally overloaded by their work. It involved three main strategies: Emotional Shielding through Professional Shie

Popular Abstract in Swedish Avhandlingens ämne är den mezuzah, en kapsel med texter ur 5 Mosebok, som bör fästas på dörrposterna i ett judiskt hem, i uppfyllande av budet i 5 Mos. 6:9/11:21: "och du skall skriva dem [dessa ord] på dörrposterna i ditt hus och på dina portar". Genom en översikt över rabbinska texter vilka behandlar budet att fästa en mezuzah på dörrposterna i hemmet inThe present study deals with different aspects of the mitsvat mezuzah in Rabbinic literature from the first to the sixteenth centuries, with some emphasis on the medieval sources. Through a charting of statements regarding the mezuzah as an object, and the mitsvat mezuzah and its fulfilment, an overview is given of the development of the mezuzah and the perception of it

The principle of force feedback is to design a sensor as a feedback system where the action of the measured variable is compensated by a force generated by feedback. Force feedback has contributed significantly to improve the quality of sensors. A characteristic feature of MEMS devices is that they are subject to random disturbances, such as Brownian motion, Johnson-Nyquist noise, and tunneling no