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These European Resuscitation Council Ethics guidelines provide evidence-based recommendations for the ethical, routine practice of resuscitation and end-of-life care of adults and children. The guideline primarily focus on major ethical practice interventions (i.e. advance directives, advance care planning, and shared decision making), decision making regarding resuscitation, education, and resear

Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems. We investigated the role of apelin signaling in the malignant behavior of cutaneous melanoma. Murine B16 and human A375 melanoma cell lines were stably transfected with apelin encoding or control vectors. Apelin overexpression

α-Synuclein (α-syn) is an intrinsically disordered protein with a highly asymmetric charge distribution, whose aggregation is linked to Parkinson’s disease. The effect of ionic strength was investigated at mildly acidic pH (5.5) in the presence of catalytic surfaces in the form of α-syn seeds or anionic lipid vesicles using thioflavin T fluorescence measurements. Similar trends were observed with

Mediterranean diet protects from both cardiovascular disease (CVD) and cancer. In the 1960s, Ancel Keys defined the concept of Mediterranean diet in the South Italian region of Cilento and proposed it as a key factor for healthy ageing in the region. The aim of the current study was to compare the prevalence of CVD and cancer between a middle-aged population from Cilento and those of a Northern Eu

Resonant photoelectron spectroscopy (RPES) has been used to probe electronic structure properties of the closed-shell [FeII(CN)6]4− and open-shell [FeIII(CN)6]3− prototype transition metal complexes in aqueous solution. Site-selective Fe 2p (L-edge) RPES mapsprovide new insight into spin-coupling processes at the core-excited metal centers, with autoionization of [FeIII(CN)6]3− showing a dramatic

The Nordic countries offer an ideal case study of the COVID-19 pandemic due to their comparability, high data quality, and variable mitigations. We investigated the age- and sex-specific mortality patterns during 2020–2021 for the five Nordic countries and analysed the total age- and sex-adjusted excess deaths, ratios of actual to expected death rates, and age-standardized excess death estimates.

Background. Albuminuria is associated with metabolic abnormalities, but these relationships are not well understood. We studied the association of metabolites with albuminuria in Hispanics/Latinos, a population with high risk for metabolic disease. Methods. We used data from 3,736 participants from the Hispanic Community Health Study/Study of Latinos, of which 16% had diabetes and 9% had an increa

Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (6

Folding two-dimensional graphene around one-dimensional III-V nanowires yields a new class of hybrid nanomaterials combining their excellent complementary properties. However, important for high-quality electrical and optical performance, needed in many applications, are well-controlled oxide-free interfaces and a tight folding morphology. To improve the interface chemistry between the graphene an

Sanfilippo C syndrome (Mucopolysaccharidosis IIIC) is a rare lysosomal storage disorder caused by mutations in the HGSNAT gene. It is characterized by a progressive and severe neurodegeneration, for which there is no treatment available. Here, we report the generation of two HGSNAT-mutated cell lines from a healthy human induced pluripotent stem cell (hiPSC) line using CRISPR/Cas9 editing. These n

Migratory birds must make complex decisions to use wind to their advantage during flight and increasing flight performance is particularly important while crossing ecological barriers. Age-related differences in how birds deal with wind have suggested experience improves necessary skills in gaining positive wind support. However, differences in wind support between age groups over ecological barri

Background: Prostate-specific antigen (PSA) measurement in midlife predicts long-term prostate cancer (PCa) mortality among white men. Objective: To determine whether baseline PSA level during midlife predicts risk of aggressive PCa in black men. Design, setting, and participants: Nested case-control study among black men in the Southern Community Cohort Study recruited between 2002 and 2009. A pr

Gas turbine systems are predominantly designed to be fuelled with gaseous fuels within a limited Wobbe index range (typically HHV=45-55 MJ/Nm3 or 1200-1480 Btu/scf). When low calorific fuel gases are fired, the engine will be forced to operate outside its design envelope. The added mass flow will typically raise the cycle pressure ratio and in two-shaft designs also raise the gas generator shaft s

Childless men are reported to have a higher risk of cardiovascular disease (CVD) and mortality. Information on inherited genetic risk for CVD has improved the predictive models. Presuming that childlessness is a proxy of infertility we aimed to investigate if childless men inherit more often genetic traits for CVD and if combining genetic and parenthood information improves predictive models for C

Detta arbete kick-startar AI (artificiell intelligens) för ledningsunderhåll i VA-branschen i Sverige. Arbetet med befintliga VA-nät är idag främst reaktivt; man reparerar läckor vartefter man blir varse dem, ibland till stora kostnader om läckan är omfattande och akut. Med denna artikel vill vi sätta fokus på proaktivt arbete med ledningsnät och diskutera riskanalys inom området. En ANN-modell soThis work kick-starts AI (artificial intelligence) for pipe management among Swedish water utilities. The current work with pipe management is mainly reactive; leaks are repaired after they are detected, sometimes with large costs if the leakage is extensive and critical. With this article, we want to focus on proactive pipe network management and discuss risk analysis in the field. A previously d

Melanoma in advanced stages is one of the most aggressive tumors and the deadliest of skin cancers. To date, the histopathological staging focuses on tumor thickness, and clinical staging is a major estimate of the clinical behavior of primary melanoma. Here we report on an observational study with in‐depth molecular profiling at the protein level including post-translational modifications (PTMs)