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Elevated Markers of Death Receptor-Activated Apoptosis are Associated with Increased Risk for Development of Diabetes and Cardiovascular Disease

Background An increased rate of cell death by apoptosis has been implicated in both diabetes and atherosclerosis. Apoptosis can be induced through activation of the death receptors TNF receptor 1 (TNFR-1), TRAIL receptor 2 (TRAILR-2) and Fas. Soluble forms of these receptors are found in plasma. The objective of this study was to determine if soluble death receptors are markers of receptor-activat

Neuroprotective dobutamine treatment upregulates superoxide dismutase 3, anti-oxidant and survival genes and attenuates genes mediating inflammation

Background: Labor subjects the fetus to an hypoxic episode and concomitant adrenomodullary catecholamine surge that may provide protection against the hypoxic insult. The beta1-adrenergic agonist dobutamine protects against hypoxia/aglycemia induced neuronal damage. We aimed to identify the associated protective biological processes involved. Results: Hippocampal slices from 6 days old mice showed

Grafchart for Procedural Operator Support Tasks

Support for procedural operations is important in industry. Within the EU/GROWTH project CHEM aimed at developing advanced decision support systems for the process industry, Grafchart, a toolbox for procedure handling based on Grafcet/Sequential Function Charts, will be used to implement a state-transition support toolbox. A brief overview of Grafchart is given, including a new Java version, JGraf

Den (o)villkorade gymnasieskolan - en förpliktande rättighet och skyldigheten att välja bort yrkesutbildningar

I kapitlet problematiseras den sociala rättigheten till skolutbildning på gymnasial nivå i Sverige med fokus på yrkes- och lärlingsutbildning utifrån ett medborgarskapsperspektiv. Syftet är att analysera hur ungdomarnas sociala rättighet till gymnasial utbildning förverkligas av statliga och kommunala aktörer. Jag avgränsar mig till att studera hur skolrepresentanter och tjänstemän på lokal nivå,

Regional innovation systems and global flows of knowledge

The literature on regional innovation systems emphasizes the role of the region as locus for interactive learning and knowledge exchange, stressing the importance of (geographical) proximity for innovation. Even though the importance of extra-regional knowledge is widely acknowledged, there has been only little emphasis on the particular role and the nature of global knowledge flows. The aim of th

End-of-life treatments in pediatric patients at a government tertiary cancer center in India

Aim: The primary objective of this study was to describe demographics and end-of-life treatments of children with cancer at a government tertiary cancer center in India. Methods: A retrospective review was undertaken of medical charts of all children younger than 18 years, who died as inpatients while undergoing treatment at the pediatric oncology department between April and September 2016. Data

Reorienting health aid to meet post-2015 global health challenges : A case study of Sweden as a donor

The international development community is transitioning from the era of the Millennium Development Goals (MDGs), ending in 2015, to the era of the Sustainable Development Goals (SDGs), which have a 2030 target. Global development assistance for health (DAH) increased substantially in the MDGs era, from US $10.8 billion in 2001 to $28.1 billion by 2012 (in 2010 US dollars), and it played a crucial