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Three-dimensional brain organoids have emerged as a valuable model system for studies of human brain development and pathology. Here we establish a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons. Using single cell RNA sequencing, we identify the presence of three molecularly distinct subtypes of human dopamine neurons w

Objective: We evaluated whether patient-reported outcome trajectories (i.e., changes over time) differed by intraoperative compartmental cartilage lesion pattern over 4–6 years following arthroscopic meniscal surgery. Methods: In this ancillary study of the Knee Arthroscopy Cohort Southern Denmark cohort, we intraoperatively categorized cartilage lesions as isolated patellofemoral, isolated tibiof

Background: Despite intense research, the prognosis for patients with advanced colorectal cancer (CRC) remains poor. The prostaglandin D2 receptors DP1 and DP2 are explored here as potential therapeutic targets for advanced CRC. Methods: A CRC cohort was analysed to determine whether DP1 and DP2 receptor expression correlates with patient survival. Four colon cancer cell lines and a zebrafish meta

Background and aims: The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. Methods: In this population-based, cross-sectional study, coronary

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https://www.webbpublicering.lu.se/innehall/skapa-redigera-och-publicera-innehall/bild-video-dokument-och-annan-media - 2026-05-27

Purpose: The purpose is to describe the Malmö Breast Tomosynthesis Screening Project from the beginning to where we are now, and thoughts for the future. Approach: In two acts, we describe the efforts made by our research group to improve breast cancer screening by introducing digital breast tomosynthesis (DBT), all the way from initial studies to a large prospective population-based screening tri

Operando resonant photoelectron spectroscopy (RPES) combined with modulated chemical excitation revealed the dynamic evolution of Ce3+/Ce4+ redox states at the surface of CeO2 during the CO oxidation reaction. Using alternating CO and O2 pulses as chemically modulated signals, we monitored the surface states in the valence band region, unveiling the evolution of electronic structure during the cat

Using several melanoma proteomics data sets we created a single analysis platform that enables the discovery, knowledge build, and validation of diagnostic, predictive, and prognostic biomarkers at the protein level. Quantitative mass-spectrometry-based proteomic data was obtained from five independent cohorts, including 489 tissue samples from 394 patients with accompanying clinical metadata. We

Abstract in Undetermined Background: Measured or modeled levels of outdoor air pollution are being used as proxies for individual exposure in a growing number of epidemiological studies. We studied the accuracy of such approaches, in comparison with measured individual levels, and also combined modeled levels for each subject's workplace with the levels at their residence to investigate the influe

Alzheimer’s disease (AD) is marked by the abnormal aggregation of amyloid-beta peptides within the central nervous system. The formation of amyloid fibrils from amyloid-beta peptides is a hallmark of AD Here, we demonstrate that the aggregation of amyloid-beta 42 spreads both spatially and temporally. By measuring the spatial propagation of amyloid-beta in macroscopic capillaries and performing Mo

We investigate the influence of AlN buffer thickness on the structural, electrical, and thermal properties of AlGaN/GaN high-electron mobility transistors (HEMTs) grown on semi-insulating SiC substrates by metal-organic chemical vapor deposition. X-ray diffraction and atomic force microscopy reveal that while thin AlN layers (120 nm) exhibit compressive strain and smooth step-flow surfaces, thicke

Introduction: Oesophageal resection carries significant morbidity and mortality. Artificial intelligence (AI) advances in medical research enable enhanced predictions, flexibility, and interpretability, especially for complex interactions and nonlinear relationships. Material and methods: We used a register-based case-control design nested within prospectively collected data from the Swedish Natio

The instability of perovskite interfaces caused by interfacial defects and heterojunction evolution hinders the realization of long-term stable inverse perovskite solar cells (IPSCs). This work reports a strategy for the study of heterojunction evolution, the effects of buried interface and carrier dynamics on the stability of perovskite films and devices in 2D/3D heterojunctions. The emphasis is

Here we report an investigation of ultrathin tin oxide films on Pt3Sn(111) using low-energy electron microscopy (LEEM), microspot low-energy electron diffraction (μ-LEED), scanning tunneling microscopy (STM), surface X-ray diffraction (SXRD), and high-resolution X-ray photoelectron spectroscopy (XPS). Oxidation at ∼390–410 °C produces triangular, two-dimensional oxide islands that nucleate rapidly

AimTo explore the meaning of lived experiences of women with a hereditary risk of breast cancer who participate in surveillance of their breasts with magnetic resonance imaging.DesignHermeneutic phenomenology.MethodsInterviews on two occasions were made with 14 women in the surveillance programme. The verbatim transcripts were analysed according to van Manen. The analysis was an insightful iterati

Understanding metabolic processes of soil fungi is essential for elucidating their ecological roles in biogeochemical cycles and responses to emergent environmental stressors. Here, we demonstrate the potential of using stable isotope probing Raman (SIP-Raman) microspectroscopy in microfluidics technology-based soil chips to trace glucose metabolism rates and stress responses in laboratory grown f

The optical response of gold-silver (Au-Ag) alloy nanoparticles is strongly influenced by their localized surface plasmon resonance (LSPR), which can be tuned by varying the particle composition. Accurate simulation of LSPR, often performed using Mie theory, critically depends on the choice of dielectric function, yet available datasets for gold, silver, and their alloys vary widely. In this work,

We report a radical extension of magnetic-resonance spectroscopy to the Terahertz (THz) spectral range by complete polarization-resolved measurement of the linear electromagnetic response of nuclear and electron spin associated magnetic resonance using principles of ellipsometry at high magnetic fields. This new method permits us to accurately test existing models and leads to discovery of new phy