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Add-on pramipexole for anhedonic depression : study protocol for a randomised controlled trial and open-label follow-up in Lund, Sweden

INTRODUCTION: Many depressed patients do not achieve remission with available treatments. Anhedonia is a common residual symptom associated with treatment resistance as well as low function and quality of life. There are currently no specific and effective treatments for anhedonia. Some trials have shown that dopamine agonist pramipexole is efficacious for treating depression, but more data is nee

Bridges, Walls, Doors : On Democracy and Nature

The concept of green democracy has been advanced in green political theory as a way to include the natural world in the political and, by that, overcome an alleged wall, a fundamental disunity, separating humans and nature in modernity and substitute it with a unity of identity that would bridge the gap between them. It has also been vested with the coupled power to transform society in a sustaina

Robust Decision Analysis under Severe Uncertainty and Ambiguous Tradeoffs : An Invasive Species Case Study

Bayesian decision analysis is a useful method for risk management decisions, but is limited in its ability to consider severe uncertainty in knowledge, and value ambiguity in management objectives. We study the use of robust Bayesian decision analysis to handle problems where one or both of these issues arise. The robust Bayesian approach models severe uncertainty through bounds on probability dis

Dietary Data in the Malmö Offspring Study : Reproducibility, Method Comparison and Validation against Objective Biomarkers

Irregular dietary intakes impairs estimations from food records. Biomarkers and method combinations can be used to improve estimates. Our aim was to examine reproducibility from two assessment methods, compare them, and validate intakes against objective biomarkers. We used the Malmö Offspring Study (55% women, 18-71 y) with data from a 4-day food record (4DFR) and a short food frequency questionn

Deep learning algorithm performs similarly to radiologists in the assessment of prostate volume on MRI

ObjectivesProstate volume (PV) in combination with prostate specific antigen (PSA) yields PSA density which is an increasingly important biomarker. Calculating PV from MRI is a time-consuming, radiologist-dependent task. The aim of this study was to assess whether a deep learning algorithm can replace PI-RADS 2.1 based ellipsoid formula (EF) for calculating PV.MethodsEight different measures of PV

The associations of self-rated health with cardiovascular risk proteins : A proteomics approach

Background: Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with biomarkers for CVD, aiming to explore potential pathways between poor SRH and CVD. Methods: Based on the Malmö Diet and Cancer Cardiovascular Cohort study, a targeted proteomics approa

Radium isotopes distribution and submarine groundwater discharge in the Bohai Sea

In order to characterize the radium distribution and submarine groundwater discharge (SGD) in the Bohai Sea area, the three isotopes 223Ra, 224Ra and 228Ra in different water bodies were measured in a 4-year period with the radium-delayed coincidence counting (RaDeCC) system. The results indicated that radium activities take an order of groundwater > coastal seawater > river water > central seawat

Computer Simulations of Continuous Flow Peritoneal Dialysis Using the 3-Pore Model-A First Experience

Background:Continuous flow peritoneal dialysis (CFPD) is performed using a continuous flux of dialysis fluid via double or dual-lumen PD catheters, allowing a higher dialysate flow rate (DFR) than conventional treatments. While small clinical studies have revealed greatly improved clearances using CFPD, the inability to predict ultrafiltration (UF) may confer a risk of potentially harmful overfill

Comparison of Voxel-Wise and Histogram Analyses of Glioma ADC Maps for Prediction of Early Therapeutic Change

Noninvasive imaging methods are sought to objectively predict early response to therapy for high-grade glioma tumors. Quantitative metrics derived from diffusion-weighted imaging, such as apparent diffusion coefficient (ADC), have previously shown promise when used in combination with voxel-based analysis reflecting regional changes. The functional diffusion mapping (fDM) metric is hypothesized to

Fiske i spåren av Covid-19 - en analys av det svenska yrkesfiskets utveckling och tillgång till stöd

Pandemin med Covid-19 har slagit hårt mot många branscher. För att mildra skadeverkningarna infördes stödåtgärder i flera länder och så även i Sverige. I den här rapporten presenterar vi en genomgång av effekterna av pandemin för svensk fiskenäring. Vi undersöker också vilka stöd näringen har kunnat söka och i vilken mån stöden passar fiskenäringens struktur.Generellt sett hade svenskt yrkesfiske

Samarbete ger lyckat resultat

Ta några ingenjörsstudenter, släng in ett par kognitionsvetarstudenter och ge dem ett problem att lösa. Ut kommer interaktiva dataspel för skolan och robotar som kan imitera människors rörelser. – Vi kombinerar doing och thinking, säger Agneta Gulz, professor i kognitionsvetenskap.

ALPHA-LINOLENIC ACID Postprandial Lipid Metabolism and Enzymatic Interesterification of Triacylgylcerols

Popular Abstract in Swedish Avhandlingen handlar om hur fett (lipider) i kosten bryts ner och transporteras i blodet för att slutligen antingen användas som energi, byggstenar i cellväggarna eller lagras i fettväven. I den här avhandlingen kan man också läsa om hur man kan modifiera fetter med hjälp av speciella proteiner: enzymer för att förbättra näringsinnehållet och dess fysikaliska egenskaperAn important indicator of the metabolic capacity of humans is the ability to regulate plasma triacylglycerol levels and to clear triacylglycerol-rich lipoproteins (TRLs) from the circulation after a meal. This is crucial since most of the day is spent in the postprandial state. High concentrations and long circulation times of TRL remnants may be detrimental since these are considered to be highly