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The liberty of religion is not easy to define or regulate. It is closely connected to other liberties and rights. Starting from individual liberty, the consequence will be a right to religion or from religion, the right to change religion or confession, and the right to transition from religion to no religion, or from no religion to religion. It is obvious that the state, the religious denominatio
B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma
Appropriate regulation of hematopoietic stem cell (HSC) numbers and function is a requisite for life-long blood cell replenishment. Knowledge of factors that regulate HSC activity is derived largely from murine model systems, with serial transplantation often considered a "gold standard" to assess longevity and self-renewal of HSCs. In the literature, we noted inconsistencies in how serial transpl
We are living in a highly dynamic, human-dominated Earth System in which non-linear, abrupt and irreversible changes are not only possible but also probable. These changes require institutional structures capable of steering human society away from critical tipping points and irreversible change and ensuring sustainable livelihoods for all. We see 2012 as a charter moment, a historic opportunity t
Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine signaling and is highly expressed in primary bone marrow (BM) cells from patients with chronic myeloid leukemia (CML). However, it has not been established whether SOCS2 is involved in CML, caused by the BCR/ABL1 fusion gene, or important for normal hematopoietic stem cell (HSC) function. In this study, we demo
Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the m
The purpose of the thesis is to increase understanding of the impact of financial institutions on regional growth. It helps to develop established concepts and perceptions on the impact of financial institutions on economic development in less well-functioning regions. Agglomeration theory is based on a general assumption of a reduced likelihood of economic cooperation through increased geographi
Aktuell status för dagvattenhantering i grannstäderna Köpenhamn och Malmö studerades med avseende på befintliga åtgärder och genomförda systemen i de båda städerna. Tillämpning av blå-gröna lösningar i de yttre delarna av Malmö började på 1990-talet och följaktligen är samarbete mellan olika avdelningar inom kommunen mer strukturerat i Malmö medan processen i Köpenhamn fortfarande är baserad på trThe current status of storm-water management in the neighbor cities of Copenhagen and Malmö was studied with respect to present measures and the implemented systems in both cities. Application of blue-green solutions in the outer parts of Malmö started in the 1990s; hence collaboration between different departments in the municipality is more structured in the city of Malmö while in Copenhagen the
A correlation between the exocrine pancreatic function and growth has been previously demonstrated in growing pigs but the data are inconsistent. This was investigated by studying the growth performance of pigs with exocrine pancreatic insufficiency (EPI) at different ages and maintained under similar conditions. Twelve 7 week old (10.5 +/- 1.3 kg) weaners, and twelve 16 week old (43 +/- 5 kg) gro
BACKGROUND: Viral gene therapy of malignant brain tumors has been restricted by the limited vector distribution within the tumors. Multipotent mesenchymal stromal cells (MSCs) and other precursor cells have shown tropism for gliomas, and these cells are currently being explored as potential vehicles for gene delivery in glioma gene therapy. OBJECTIVE: To investigate MSC migration in detail after i
Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To address this, we generated a mouse model in which the mixed-lineage leukemia/eleven-nineteen-leukemia (M
Diabetes mellitus (DM) type II is increasing rapidly worldwide. Patients with DM II have a greater atherosclerotic burden and higher risk of developing cardiovascular complications. Inflammation has been proposed as the main cause for the high risk of atherosclerotic disease in DM II. In this study, we compared markers of inflammation and fibrous repair in plaques from subjects with and without DM
Studies on fibre intake and incident colorectal cancer (CRC) indicate inverse associations. Differences by tumour stage have not been examined. We examined associations between fibre intake and its sources, and incidental CRC. Separate analyses were carried out on the basis of sex, tumour location and the Tumour, Node, Metastasis (TNM) classification. The Malmö Diet and Cancer Study is a populatio
Background:Observational studies have mostly found no association between self-reported whole-grain (WG) intake and prostate cancer (PCa). Plasma alkylresorcinol metabolites have been suggested as biomarkers for WG intake in free-living populations. Methods:We investigated the major dietary and lifestyle determinants of plasma alkylresorcinol metabolites in a nested case-control study (1,016 cases
Background: Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity. Here, we investigated cerebrospinal fluid (CSF) levels of PDGFR-β in suicide attempters and healthy controls and correlated PDGFR-β to depression symptom severity. Metho
