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Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type II diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycaemia toxicity and physical inactivity have been suggested as potential links between diabetes and OA, and have been

AIMS: Carbohydrate antigen 125 (CA125), a mucin produced by serosal cells in response to mechanical and inflammatory stimuli, has emerged as an important biomarker to guide risk stratification in heart failure (HF). The prognostic value of CA125 in acute coronary syndrome (ACS) patients is less explored.METHODS: In a cohort of 524 ACS patients (73% males, mean age 67 ± 12 years), we assessed the a

Many forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be detected are cells. In order to develop and benchmark algorithms and neural networks that can perform this task, high-quality datasets with annotate

The Large Interferometer For Exoplanets (LIFE) is a proposed space mission that enables the spectral characterization of the thermal emission of exoplanets in the solar neighborhood. The mission is designed to search for global atmospheric biosignatures on dozens of temperate terrestrial exoplanets and it will naturally investigate the diversity of other worlds. Here, we review the status of the m

CONTEXT: As part of a broader institutional initiative, the serious illness care program was implemented in a multi-site academic primary care practice. After 2 years, a minority was observed to be documenting serious illness conversations routinely.OBJECTIVES: We aimed to learn about the motivations and actions of clinicians who routinely conducted and documented serious illness conversations.MET

Dwell time is crucial for railway operations, for example, 20% of the total travel time in a mass transit context in the Paris region. With this, it is also a source of delays due to its variability. One way to ensure the robustness of a timetable is to add margins as buffer time that can be consumed to absorb short delays. Much work has been done on run time margins, but dwell time margins receiv

Collagen VII is an essential anchoring protein in the basement membrane zone, maintaining the attachment of stratified and pseudostratified epithelia to the underlying interstitial matrix. However, collagen VII is largely unexplored in normal lungs and idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive accumulation of extracellular matrix (ECM) and aberrant re-epithelializat

Bioelectronics holds great potential as therapeutics, but introducing conductive structures within the body poses great challenges. While implanted rigid and substrate-bound electrodes often result in inflammation and scarring in vivo, they outperform the in situ-formed, more biocompatible electrodes by providing superior control over electrode geometry. For example, one of the most researched met

Introduction: Little is known of the processes that trigger neutrophil activation in the joint of patients with oligoarticular juvenile idiopathic arthritis (oJIA), and if synovial fibroblasts (S-Fib) play an important role in the activation. Therefore, we aimed to investigate whether S-Fib derived from oJIA patients drive neutrophil activation. Methods: Synovial fluid (SF) was collected from pati

This study employs computational algorithms to automatically identify and classify features in X-Ray fluorescence (XRF) microscopy images. Principal component analysis (PCA) and unsupervised machine learning algorithms, such as Gaussian mixture (GM) clustering, are implemented to label features on a collection of XRF maps of human atherosclerotic plaque samples. The investigation involves the hard

Certainty equivalence adaptive controllers are analysed using a “data-driven Riccati equation”, corresponding to the model-free Bellman equation used in Q-learning. The equation depends quadratically on data correlation matrices. This makes it possible to derive simple sufficient conditions for stability and robustness to unmodeled dynamics in adaptive systems. The paper is concluded by short rema

Toxicological testing in mice was conducted on PM2.5 particles from stressed burning of two types of candles (white and blue) and on PM2.5 collected indoor and outdoor of fifteen occupied homes in southern Sweden. As an indicator of toxicity, the ability to generate Reactive Oxygen Species (ROS) was also assessed for all pooled samples: candle white, candle blue, indoor, and outdoor. Higher toxici

Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early

Kapitlet ger en sammanfattande bild av etableringsvillkoren för ungdomar (16-19 år) och unga vuxna (20-24 år) samt deras utanförskap i Sverige från början av 1990-talet fram till idag. Kapitlet omfattar tre avsnitt. I det första avsnittet ges en bakgrundsteckning om ungdomars etablering på den svenska arbetsmarknaden. Översikten sammanfattar forskningsresultat om arbetsmarknad, utbildning och förs

On-demand droplet generation from a continuously flowing stream of aqueous phase has profound applications in dropletbased microfluidics for rare event encapsulation studies. Here, we present acoustic relocation-based droplet generation from co-flowing immiscible fluids in an on-demand manner using bulk acoustic wave (BAW). After on-demand droplet generation, droplets are isolated using the same a

This study describes frequencies and associations between eating difficulties, assisted eating and nutritional status in 520 elderly patients in hospital rehabilitation. Eating difficulties were observed during a meal and nutritional status was assessed with Subjective Global Assessment form. Eighty-two percent of patients had one or more eating difficulties, 36% had assisted eating and 46% malnut

Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma r

Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF i

Lignin is the second most abundant naturally produced organic polymer on earth. Lignin‐modifying enzymes (LMEs) are produced by the white‐rot fungi as products of secondary metabolism, since lignin degradation does not provide any energy to the fungus. The main oxidative enzymes include the peroxidases‐lignin peroxidase (LiP) (diarylpropane: oxygen, hydrogen peroxide oxidoreductase), manganese per