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Fast nanoscale imaging of strain in a multi-segment heterostructured nanowire with 2D Bragg ptychography

Developing semiconductor devices requires a fast and reliable source of strain information with high spatial resolution and strain sensitivity. This work investigates the strain in an axially heterostructured 180 nm-diameter GaInP nanowire with InP segments of varying lengths down to 9 nm, simultaneously probing both materials. Scanning X-ray diffraction (XRD) is compared with Bragg projection pty

The possible role of the vasopressin system in hematopoiesis

Vasopressin is a pleiotropic hormone that controls body fluid homeostasis. Vasopressin has also been proposed to be involved in erythropoiesis, thrombocyte activity and inflammation. However, whether increasing vasopressin is associated with changes in hematopoietic markers is not known. To evaluate this gap of knowledge we measured the vasopressin marker copeptin and markers of erythropoiesis (er

The coexistence of diabetes, hypertension and obesity is associated with worse pain outcomes following exercise for osteoarthritis : A cohort study on 80,893 patients

OBJECTIVES: To investigate how the co-occurrence of diabetes, hypertension and overweight/obesity is associated with pain following an exercise intervention for knee and hip osteoarthritis (OA).METHODS: Register-based cohort study. We included people from the Swedish Osteoarthritis Register who underwent education and exercise for knee or hip OA. Diabetes and hypertension were defined using medica

Digital self-management, analgesic use and patient-reported outcomes in knee or hip osteoarthritis

ObjectiveTo investigate changes in analgesic use before and after participation in a digital first-line treatment program (exercise and patient education) in persons with knee or hip OA and to explore associations between these changes in medication use and participant-reported pain and function.DesignRetrospective cohort study with pre-post measures.SettingCommunity setting, Sweden.ParticipantsIn

Lifestyle and cardiovascular risk factors in a Swedish primary care population with self-reported psychiatric symptoms

Objective: Individuals with psychiatric illness suffer from poorer physical health compared with the general population and have a higher risk of developing cardiovascular and metabolic diseases. This cross-sectional study aims to describe the prevalence of lifestyle and cardiovascular risk factors and the association with self-reported psychiatric symptoms in a population of 40-year-old individua

Plasma Metabolome Predicts Aortic Stiffness and Future Risk of Coronary Artery Disease and Mortality After 23 Years of Follow-Up in the General Population

BACKGROUND: Increased aortic stiffness (arteriosclerosis) is associated with early vascular aging independent of age and sex. The underlying mechanisms of early vascular aging remain largely unexplored in the general population. We aimed to investigate the plasma metabolomic profile in aortic stiffness (vascular aging) and associated risk of incident cardiovascular disease and mortality.METHODS AN

Repatriating An Edifying Past : The Diaspora Ukrainian Authoritarian Right and Power Over Memory, 1991-2021

The recent history of the Ukrainian authoritarian far right is one of paradoxes. If one looks at the polls, it has performed poorly; its modest successes have been regional and short-lived. On the other hand, it has been highly successful in terms of shaping memory politics in the country. It has had a disproportional influence on history writing, having invested significant efforts into building

Urgent endovascular repair of juxtarenal/pararenal aneurysm by off-the-shelf multibranched endograft

Objective: To report outcomes of urgent juxtarenal/pararenal aneurysms (J/P-AAAs) managed by off-the-shelf multibranched thoracoabdominal endografts (Cook, T-branch). Methods: In this observational, multicenter, retrospective study, patients with J/P-AAAs treated by urgent endovascular repair by T-branch in 23 European aortic centers, from 2013 to 2023, were analyzed. Contained J/P-AAAs rupture, p

Influence of AFIR's charging station spacing requirement on heavy-duty vehicle electrification rate

Den snabba utvecklingen av elektrifiering av vägtransporter i Sverige kräver forskningsbaserade beslut om placeringen av laddinfrastruktur. Europeiska unionens (EU) nya förordning för infrastruktur för alternativa bränslen (AFIR) specificerar det maximala tillåtna avståndet mellan offentliga snabbladdningsstationer (FCS) för tunga lastbilar längs det transeuropeiska transportnätverket (TEN-T). EffThe rapid progression of the electrification of road transport in Sweden requires effective research based decisions on the location of charging infrastructure. The new European Union (EU) regulation for alternative fuel infrastructure (AFIR) specifies the maximum allowed distance between public fast-charging stations (FCSs) for heavy-duty trucks along the Trans-European Transport Network (TEN-T).

Proteomic biomarkers and pathway analysis for progression to heart failure in three epidemiological representative cohorts

AIMS: Biomarkers associated with asymptomatic ventricular dysfunction might improve risk stratification and identify pathways leading to heart failure (HF). We explored the association between proteomic biomarkers and left ventricular hypertrophy (LVH), diastolic dysfunction (DD) and incident HF in three population-based cohorts.METHODS AND RESULTS: A chip was used to measure 92 protein biomarkers

Far Away from Human-land : Kafka’s Nonhumans in Günther Anders and Walter Benjamin

In 1934, Walter Benjamin published his major study Franz Kafka: Zur zehnten Wiederkehr seines Todestages. In the same year, Günther Anders, another German Jew in exile, gave a lecture on Kafka which later, in postwar years, developed into a small book titled Kafka, Pro und Contra. Bringing these two in dialogue—the much-celebrated essay by Benjamin and the generally overlooked book by Anders—the p

Specialiserad palliativ hemsjukvård: högre kvalitet till lägre kostnad?

Syftet med studien var att undersöka om patienter som erhåller specialiserad palliativ hemsjukvård (SPH) får bättre palliativ vård, med färre besök på akutmottagning och vårddagar på sjukhus samt i högre utsträckning kan dö i sitt eget hem jämfört med de patienter som inte ansluts till SPH. Vi ville även undersöka om SPH är kostnadsbesparande.Genom retrospektiv journalgenomgång inkluderades de 150

Software Performance of the ATLAS Track Reconstruction for LHC Run 3

Charged particle reconstruction in the presence of many simultaneous proton–proton (pp) collisions in the LHC is a challenging task for the ATLAS experiment’s reconstruction software due to the combinatorial complexity. This paper describes the major changes made to adapt the software to reconstruct high-activity collisions with an average of 50 or more simultaneous pp interactions per bunch cross

Combining CD40 agonist mitazalimab with mFOLFIRINOX in previously untreated metastatic pancreatic ductal adenocarcinoma (OPTIMIZE-1) : a single-arm, multicentre phase 1b/2 study

Background: Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed to assess the safety and antitumour activity of mitazalimab, a human CD40 agonistic IgG1 antibody, with modified FOLFIRINOX (mFOLFIRINOX; fluorouracil, leucovorin, oxaliplatin, and irinotecan), in chemotherapy-naive patients

Forced LMX1A expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons

The differentiation of human pluripotent stem cells into ventral mesencephalic dopaminergic (DA) fate is relevant for the treatment of Parkinson's disease. Shortcuts to obtaining DA cells through direct reprogramming often include forced expression of the transcription factor LMX1A. Although reprogramming with LMX1A can generate tyrosine hydroxylase (TH)-positive cells, their regional identity rem