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Bimolecular Reaction Mechanism in the Amido Complex-Based Atomic Layer Deposition of HfO2

The surface chemistry of the initial growth during the first or first few precursor cycles in atomic layer deposition is decisive for how the growth proceeds later on and thus for the quality of the thin films grown. Yet, although general schemes of the surface chemistry of atomic layer deposition have been developed for many processes and precursors, in many cases, knowledge of this surface chemi

Accurate prediction of B-form/A-form DNA conformation propensity from primary sequence : A machine learning and free energy handshake

DNA carries the genetic code of life, with different conformations associated with different biological functions. Predicting the conformation of DNA from its primary sequence, although desirable, is a challenging problem owing to the polymorphic nature of DNA. We have deployed a host of machine learning algorithms, including the popular state-of-the-art LightGBM (a gradient boosting model), for b

Crisis and Public Support for the Euro, 1999–2014

This contribution analyses the evolution of public support for the single European currency, the euro, from 1990 to 2014 for a 12-country sample of the euro area (EA-12), focusing on the most recent period of the financial and sovereign debt crisis, starting in 2008. We find that citizens’ support for the euro on average was marginally reduced during the first six years of the crisis, and that sup

Article 17 DSM Directive: the Swedish proposal (Part 2)

Commentary and analysis of the proposal of the Swedish Ministry of Justice (Ds 2021:30) concerning implementation of Article 17 Directive 2019/790 on copyright and related rights in the Digital Single Market (DSM Directive). Part 2 of 2.

Omega-3 fatty acids for inflamed depression - A match/mismatch study

Despite decades of research on the pathophysiology of depression, the development of new therapeutic interventions has been slow, and no biomarkers of treatment response have been clinically implemented. Several lines of evidence suggest that the clinical and biological heterogeneity among patients with major depressive disorder (MDD) has hampered progress in this field. MDD with low-grade inflamm

Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals

Background: Although several cardiovascular, demographic, genetic and lifestyle factors have been associated with cognitive function, little is known about what type of cognitive impairment they are associated with. The aim was to examine the associations between different risk factors and future memory and attention/executive functions, and their interaction with APOE genotype. Methods: Participa

Repatriating An Edifying Past : The Diaspora Ukrainian Authoritarian Right and Power Over Memory, 1991-2021

The recent history of the Ukrainian authoritarian far right is one of paradoxes. If one looks at the polls, it has performed poorly; its modest successes have been regional and short-lived. On the other hand, it has been highly successful in terms of shaping memory politics in the country. It has had a disproportional influence on history writing, having invested significant efforts into building

Exploring the Functional Landscape of the p53 Regulatory Domain : The Stabilizing Role of Post-Translational Modifications

This study focuses on the intrinsically disordered regulatory domain of p53 and the impact of post-translational modifications. Through fully atomistic explicit water molecular dynamics simulations, we show the wealth of information and detailed understanding that can be obtained by varying the number of phosphorylated amino acids and implementing a restriction in the conformational entropy of the